Results 161 to 170 of about 81,731 (259)

Azelaic acid alleviates UVB-induced photoaging in keratinocytes by restoring Smad-dependent TGF-β signaling. [PDF]

Front Med (Lausanne)
Lai W, Wang L, Tang W, Liu Y.
europepmc   +1 more source

Cholesterol Drives IFITM3+ Microglia Activation and Induces STING Mediated Neuroinflammation After Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
After ischemic stroke, cholesterol accumulation in microglia is accompanied by the emergence of a pro‐inflammatory IFITM3+ subset with aberrant esterification and lipid droplet buildup. This metabolic stress is linked to mitochondrial dysfunction, STING activation, sustained neuroinflammation, and white matter injury.
Yue Cheng, Yuxi Zhou, Yonghui Chen, Tianni Shen, Yan Li, Chen Chen, Qiuyue Fan, Jie Qi, Peiying Li, Yueman Zhang   +9 more
wiley   +1 more source

THBS4 Regulates Pulmonary Hypertension via TGF-β/SMAD2 Signaling. [PDF]

Hypertension
Zeng J, Li D, Wang J, Wang R, Huang Z, Bai D, Liu X, Sun D, Fu G, Kang K, Liu X, Yang L, Zhao F, Luo L, Li R, Zhang Y, Gou D.   +16 more
europepmc   +1 more source

Vorinostat Mitigates Early Brain Injury Following Subarachnoid Hemorrhage Through Modulation of the C3aR1/TGF‐β/Smad Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
C3aR1 mediates microglial activation after SAH in part through the TGF‐β/Smad signaling pathway. Vorinostat alleviates early brain injury after SAH by reducing C3aR1 levels. ABSTRACT Background Excessive microglial activation after subarachnoid hemorrhage (SAH) contributes to early brain injury (EBI) and poor clinical outcomes.
Chonghui Zhang, Yifan Xu, Junshan Wan, Jinpeng Wu, Chao Wang, Yugong Feng   +5 more
wiley   +1 more source

Interaction between Smad2 and retinoid signaling

Developmental Biology, 2006
Festing, Maria H., Keplinger, Kara, Weinstein, Michael B.   +2 more
openaire   +1 more source

Post-transcriptional activation of TGF-β signaling via SMAD mRNA stabilization by EIF4A3 promotes EMT and metastasis in gastric cancer. [PDF]

Cell Biol Toxicol
Liu Y, Zhang Y, Dou W, Peng W, Cheng M, Zhou Y, Shao Q, Wu Y.   +7 more
europepmc   +1 more source

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Central role of pericytes across major pulmonary diseases. Conceptual wheel diagram illustrating the central role of lung pericytes across diverse pulmonary disease states. A pericyte positioned at the center expresses canonical markers, including PDGFRβ, CD146, and NG2, and connects radially to five major disease contexts.
Stuti Agarwal, Anuradha Bankar, Vinicio A. de Jesus Perez   +2 more
wiley   +1 more source

Tristetraprolin attenuates schistosomiasis-induced liver fibrosis through m⁶A-mediated regulation of TGF-β1 mRNA stability. [PDF]

PLoS Pathog
Zhao X, Wang X, Liu K, Fang Q, Wang C, Mei G, Qu L, Zhang J, Feng J, Yang W, Zhu J, Zhuo H, Kuang N, Qiu X, Deng Z, Luo Q, Jin X, Jiang L, Li X, Dong H, Zhou R.   +20 more
europepmc   +1 more source

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 345-356, August 2026.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Cardiomyocyte-derived BDNF restricts cardiac fibrosis by decreasing the activity of the TGF-β/Smad2/3 pathway and increasing Smad7 expression. [PDF]

Front Cell Dev Biol
Zhu Y, Ran Y, Fu T, Zheng X, Chen Y, Liang C, Li Y, Huang R, Zhao H, Pan X, Yuan Z, Pu Q, Zeng Z, Feng S, Qi X, Lv L, Zhan L, Chen Y, Cai D.   +18 more
europepmc   +1 more source