Results 101 to 110 of about 77,825 (245)

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Exosomal hnRNPA1‐delivered miR‐27a‐3p inhibits the radiation‐induced bystander effect in cervical cancer

Precision Radiation Oncology, EarlyView.
The study showed that TOMO‐mediated RIBE is activated by decreasing exosomal hnRNPA1 protein level and its capability to packaging miR‐27a‐3p. These new findings infer that hnRNPA1 is a novel inhibitor of RIBE, which potentiates to be a new therapeutic target for improving the efficacy of radiotherapy.
Meng‐Qi Yang, Ping Huang, Yun‐Rui Song, Yong‐Zhong Wu, Zheng Tang, Lu Zhang, Huan‐Li Luo, Yun‐Chang Liu, Dan Li, Fu Jin, Jiang‐Dong Sui, Ying Wang   +11 more
wiley   +1 more source

SMAD2 linker phosphorylation impacts overall survival, proliferation, TGFβ1-dependent gene expression and pluripotency-related proteins in NSCLC

British Journal of Cancer
Abstract Background We investigated the impact of SMAD2 linker phosphorylation (pSMAD2L) on overall and disease-free survival, signal transduction, as well as cancer-related processes in non-small cell lung cancer (NSCLC).
Dörte Nitschkowski, Tim Vierbuchen, Holger Heine, Jochen Behrends, Norbert Reiling, Martin Reck, Klaus F. Rabe, Christian Kugler, Ole Ammerpohl, Daniel Drömann, Thomas Muley, Mark Kriegsmann, Georgious T. Stathopoulos, Kristina A. M. Arendt, Torsten Goldmann, Sebastian Marwitz   +15 more
openaire   +2 more sources

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, EarlyView.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Proteome-wide Mendelian randomization identifies causal plasma proteins in prostate cancer development

Human Genomics
Background The etiology of prostate cancer remained elusive, whether plasma protein levels are associated with prostate cancer is still unknown. Methods We have performed Mendelian randomization analyses to calculate the causal effects of plasma proteins
Jian Wu, Zitong Yang, Jiafeng Ding, Sida Hao, Hong Chen, Ke Jin, Cheng Zhang, Xiangyi Zheng   +7 more
doaj   +1 more source

Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle

Frontiers in Oncology
BackgroundRenal cell carcinoma (RCC) is a prevalent type of malignant tumor with high morbidity and mortality. The TGF-β/Smad signaling pathway plays a significant role in the development and progression of RCC.MethodsThis study explored the effects of ...
Shengyou Song, Yalin Song
doaj   +1 more source