Results 221 to 230 of about 77,825 (245)

PROTEIN PHOSPHATASE PPM1A INHIBITION ATTENUATES OSTEOARTHRITIS VIA REGULATION OF TGF-Β/SMAD2 SIGNALLING IN CHONDROCYTES

Orthopaedic Proceedings, 2023
TGF-β/Smad2 signaling is considered to be one of the important pathways involved in osteoarthritis (OA) and protein phosphatase magnesium-dependent 1A (PPM1A) functions as an exclusive phosphatase of Smad2 and regulates TGF-β signaling, here, we investigated the functional role of PPM1A in OA pathogenesis.PPM1A expressions in both human OA cartilage ...
Q. Ge, Z. Shi, J. Ying, J. Chen, W. Yuan, P. Wang, D. Chen, X. Feng, P. Tong, H. Jin   +9 more
openaire   +1 more source

Simvastatin reduces TGF-β1-induced SMAD2/3-dependent human ventricular fibroblasts differentiation: Role of protein phosphatase activation [PDF]

International Journal of Cardiology, 2018
Excessive cardiac fibrosis due to maladaptive remodeling leads to progression of cardiac dysfunction and is modulated by TGF-β1-activated intracellular phospho-SMAD signaling effectors and transcription regulators. SMAD2/3 phosphorylation, regulated by protein-phosphatases, has been studied in different cell types, but its role in human ventricular ...
Gracious Ross, , Ekhson Holmuhamedov
exaly   +4 more sources

A tale of two proteins: Differential roles and regulation of Smad2 and Smad3 in TGF‐β signaling

Journal of Cellular Biochemistry, 2007
AbstractTransforming growth factor‐beta (TGF‐β) is an important growth inhibitor of epithelial cells, and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to tumorigenesis. Smad2 and Smad3 are direct mediators of TGF‐β signaling, however little is known about the selective activation of Smad2 versus Smad3 ...
Kimberly A, Brown, Jennifer A, Pietenpol, Harold L, Moses   +2 more
exaly   +3 more sources

ANGIOTENSIN RECEPTOR ANTAGONIST REPAIRS THE AORTA OF RATS WITH AORTIC DISSECTION BY REGULATING SMAD2/SMAD4 PROTEIN

Acta Medica Mediterranea, 2022
<p style="text-align:justify;font-size:9px;font-family:Times;"><b><i>Objective:</i></b><i> To analyse the mechanism of angiotensin receptor antagonist-mediated repair of the aorta in rats with aortic dissection through regulation of Smad2 / Smad4 proteins.<span> </span></i></p><p ...
openaire   +1 more source

Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent signalling

2012
13 páginas, 8 figuras -- PAGS nros.
Santibáñez, Juan F., Letamendía, Ainhoa, Pérez-Barriocanal, Fernando, Silvestri, Cristoforo, Saura, Marta, Vary, Calvin P. H., López-Novoa, José M., Attisano, Liliana, Bernabéu, Carmelo   +8 more
openaire   +1 more source

Abstract 3035: Bone morphogenetic proteins signal through Smad2 and Smad3 to regulate cell migration and proliferation

Cancer Research, 2012
Abstract The TGF-β superfamily consists of a large number of growth factors, including transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMPs) that regulate cellular proliferation, differentiation, invasion, migration and apoptosis.
Alisha Holtzhausen, Tam How, Bradley C. Gersh, Gerard C. Blobe   +3 more
openaire   +1 more source

Role of Tisp40/Smad2 Protein in High Glucose-induced Renal Interstitial Fibrosis

Journal of Clinical and Nursing Research
Objective: To observe the effect of high glucose staining on human renal tubular epithelial cells (HKC) and to investigate the role of Tisp40/Smad2 protein in diabetes-induced renal fibrosis. Methods: Human renal tubular epithelial cells (HKC) were cultured in vitro and cells were incubated with a final concentration of 25, 50, and 100 mM high glucose ...
Yapeng Wang, Ruixiao Wang, Xueyi Wang
openaire   +1 more source

Understanding the role of USP11, a novel SMAD2-interacting protein, in TGF-B signalling

2011
La signalisation de TGF-β contrôle des processus cellulaires variés au cours du développement et de l'âge adulte. Des perturbations dans la cascade TGF-β sont associées à plusieurs maladies humaines. SMAD2 est l'un des principaux effecteurs de cette cascade et sa fonction est modulée par des modifications post-traductionnelles comme l'ubiquitination ...
openaire   +1 more source

Expression and localization of Smad1, Smad2 and Smad4 proteins in rat testis during postnatal development

2010
Aim: To study the expression and regulation of Smad1, Smad2 and Smad4 proteins (intracellular signaling molecules of transforming growth factor-β family) in rat testis during postnatal development. Methods: The whole testes were collected from SD rats aged 3, 7, 14, 28 and 90 (adult) days.
Jin, Y, Hu, J, Wang, RA, Liu, XP, Zhang, YQ, Xu, RJ   +5 more
openaire   +1 more source

Protein phosphatase SMP1 is a negative regulator of tumor suppressor SMAD2

Journal of Surgical Research, 2006
X. Lin, X. Duan, Y. Liang, K. Wrighton, J. Wang, F. Brunicardi, X. Feng   +6 more
openaire   +1 more source