Results 11 to 20 of about 118,693 (302)

Myoneurin regulates BMP signaling by competing with Ppm1a for Smad binding

iScience, 2022
Summary: A delicate balance of BMP activity is critical for tissue formation and organogenesis. However, the mechanical molecular details in ensuring the proper duration and intensity of BMP signaling have yet to be fully elucidated.
Shuyan Yang, Guozhu Ning, Yiming Hou, Yu Cao, Jin Xu, Jianxin Wu, Ting Zhang, Qiang Wang   +7 more
doaj   +1 more source

HDAC1 regulates inflammation and osteogenic differentiation of ankylosing spondylitis fibroblasts through the Wnt-Smad signaling pathway

Journal of Orthopaedic Surgery and Research, 2022
Ankylosing spondylitis (AS) is a refractory autoimmune disease, whose typical pathology is the development of inflammation to ossification and ankylosis.
Yong Zeng, Rui He, Yong Liu, Ting Luo, Qing Li, Yu He, Miao Fang, Taiping Wang   +7 more
doaj   +1 more source

The Role of Transforming Growth Factor Beta and Smad Receptors in Determining Prognosis in High-Grade Primary Brain Tumors: Glioblastoma Multiforme

Brazilian Neurosurgery, 2023
Introduction High-grade primary brain tumors cause serious morbidity and mortality. This study aimed to investigate the role of transforming growth factor beta (TGF-β) and suppressor of mothers against decapentaplegic (Smad) receptors in high-grade ...
Güven Gürsoy, Mustafa Barutçuoğlu, Oya Nermin Sivrikoz, Sevtap Gökalp, Seda Vatansever   +4 more
doaj   +1 more source

SMAD proteins control DROSHA-mediated microRNA maturation [PDF]

Nature, 2008
MicroRNAs (miRNAs) are small non-coding RNAs that participate in the spatiotemporal regulation of messenger RNA and protein synthesis. Aberrant miRNA expression leads to developmental abnormalities and diseases, such as cardiovascular disorders and cancer; however, the stimuli and processes regulating miRNA biogenesis are largely unknown.
Brandi N, Davis, Aaron C, Hilyard, Giorgio, Lagna, Akiko, Hata   +3 more
openaire   +2 more sources

Eps15R is required for bone morphogenetic protein signalling and differentially compartmentalizes with Smad proteins [PDF]

Open Biology, 2012
Transforming growth factor β superfamily members signal through Smad transcription factors. Bone morphogenetic proteins (BMPs) act via Smads 1, 5 and 8 and TGF-βs signal through Smads 2 and 3.
Elizabeth M. Callery, Chong Yon Park, Xin Xu, Haitao Zhu, James C. Smith, Gerald H. Thomsen   +5 more
doaj   +1 more source

Nucleocytoplasmic shuttling of Smad proteins [PDF]

Cell Research, 2008
Nuclear accumulation of active Smad complexes is crucial for transduction of transforming growth factor beta (TGF-beta)-superfamily signals from transmembrane receptors into the nucleus. It is now clear that the nucleocytoplasmic distributions of Smads, in both the absence and the presence of a TGF-beta-superfamily signal, are not static, but instead ...
openaire   +2 more sources

Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling [PDF]

Journal of Biological Chemistry, 2016
TGF-β is a pleiotropic cytokine that regulates a wide range of cellular actions and pathophysiological processes. TGF-β signaling is spatiotemporally fine-tuned. As a key negative regulator of TGF-β signaling, Smad7 exerts its inhibitory effects by blocking receptor activity, inducing receptor degradation or interfering with Smad-DNA binding.
Xiaohua, Yan, Hongwei, Liao, Minzhang, Cheng, Xiaojing, Shi, Xia, Lin, Xin-Hua, Feng, Ye-Guang, Chen   +6 more
openaire   +2 more sources

Upregulation of Id1 by Epstein-Barr Virus-encoded LMP1 confers resistance to TGFβ-mediated growth inhibition [PDF]

, 2010
Background Epstein-Barr virus (EBV)-encoded LMP1 protein is commonly expressed in nasopharyngeal carcinoma (NPC). LMP1 is a prime candidate for driving tumourigenesis given its ability to activate multiple signalling pathways and to alter the expression
Lo, Angela K. F., Dawson, Christopher W., Lo, Kwok W., Yu, Yanxing, Young, Lawrence S.   +4 more
core   +2 more sources

Regulation of cell proliferation by Smad proteins [PDF]

Journal of Cellular Physiology, 2002
AbstractTransforming growth factor‐β (TGF‐β) family members which include TGF‐βs, activins, and bone morphogenetic proteins (BMPs) regulate a broad spectrum of biological responses on a large variety of cell types. TGF‐β family members initiate their cellular responses by binding to distinct receptors with intrinsic serine/threonine kinase activity and
Peter, Ten Dijke, Marie-José, Goumans, Fumiko, Itoh, Susumu, Itoh   +3 more
openaire   +2 more sources

Role of growth factors in the pathogenesis of tissue fibrosis in systemic sclerosis. [PDF]

, 2010
The most severe clinical and pathologic manifestations of systemic sclerosis (SSc) are the result of a fibrotic process characterized by the excessive and often progressive deposition of collagen and other connective tissue macromolecules in skin and ...
Castro, Susan V., Jimenez, Sergio A., Piera-Velazquez, Sonsoles   +2 more
core   +2 more sources