Results 91 to 100 of about 5,853,742 (252)
, 2008 Supplementary Fig. S2 from Administration of PLK-1 small interfering RNA with atelocollagen prevents the growth of liver metastases of lung ...
Yuri Kamitsuji (15040652) +12 more
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Effective small interfering RNA delivery in vitro via a new stearylated cationic peptide
, 2015 Baoling Chen,1,2 Ran Pan,1,2 Diana Askhatova,1 P Chen1,21Department of Chemical Engineering, 2Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON, CanadaAbstract: A crucial bottleneck in RNA interference-based gene therapy is
Chen P, Chen BL, Askhatova D, Pan R
core
Small interfering RNA (siRNA) als Arzneimittel: Wirkprinzipien und Effekte
, 2020 Nukleinsäurebasierte Wirkstoffe ermöglichen eine Erweiterung der therapeutischen Ansätze auf Zielstrukturen, die nicht von konventionellen Wirkstoffen erreicht werden können.
Scholl, C. +3 more
core +1 more source
Effect of small interfering RNAs on matrix metalloproteinase 1 expression
Biotechnology Reports, 2014 Three small double strand siRNAs (506-MMP1, 859-MMP1 and 891-MMP1), each contains 25–26 nucleotides, with high specific to human MMP1 were designed according to mRNA sequence of human MMP1 (NCBI, NM_002421). To monitor the MMP1 gene expression, the total
Gen-Hung Chen +3 more
doaj +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
, 2007 Supplementary Table from Suppression of cervical carcinoma cell growth by intracytoplasmic codelivery of anti-oncoprotein E6 antibody and small interfering ...
Deniz Dalkara (258466) +6 more
core +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
, 2006 Supplementary Fig. S1 from Influence of small interfering RNA corresponding to ets homologous factor on senescence-associated modulation of prostate ...
Inkyoung Lee (14897555) +2 more
core +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source