Updates in Small Interfering RNA for the Treatment of Dyslipidemias. [PDF]
Curr Atheroscler Rep, 2023 Abstract Purpose of Review Atherosclerotic cardiovascular disease (ASCVD) is still the leading cause of death worldwide. Despite excellent pharmacological approaches, clinical registries consistently show that many people with dyslipidemia do not achieve optimal management, and many of them are treated with low-intensity
Carugo S +5 more
europepmc +3 more sources
Potential Application of Small Interfering RNA in Gastro-Intestinal Tumors. [PDF]
Pharmaceuticals (Basel), 2022 Despite the progress made in the diagnoses and therapy of gastrointestinal cancers, these diseases are still plagued by a high mortality. Thus, novel therapeutic approaches are urgently required.
Losurdo P +10 more
europepmc +2 more sources
Unzipping and binding of small interfering RNA with single walled Carbon Nanotube: a platform for small interfering RNA delivery [PDF]
J. Chem. Phys. 136, 065106 (2012), 2012 In an effort to design efficient platform for siRNA delivery, we combine all atom classical and quantum simulations to study the binding of small interfering RNA (siRNA) by pristine single wall carbon nanotube (SWCNT). Our results show that siRNA strongly binds to SWCNT surface via unzipping its base-pairs and the propensity of unzipping increases with
Santosh, Mogurampelly +4 more
arxiv +6 more sources
Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges. [PDF]
J Biomed Sci, 2023 RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles extending beyond its applications in vaccines, in which it is used in the response to the COVID-19 pandemic.
Kang H +6 more
europepmc +2 more sources
Small Interfering RNA for Gliomas Treatment: Overcoming Hurdles in Delivery. [PDF]
Front Cell Dev Biol, 2022 Gliomas are central nervous system tumors originating from glial cells, whose incidence and mortality rise in coming years. The current treatment of gliomas is surgery combined with chemotherapy or radiotherapy. However, developing therapeutic resistance
Teng XQ, Qu J, Li GH, Zhuang HH, Qu Q.
europepmc +2 more sources
Phenotypic Alteration of BMDM In Vitro Using Small Interfering RNA. [PDF]
Cells, 2022 Autologous macrophage transfer is an emerging platform for cell therapy. It is anticipated that conventional macrophage reprogramming based on ex vivo polarization using cytokines and ligands of TLRs may enhance the therapeutic effect.
Halimani N +11 more
europepmc +2 more sources
siRNAEfficacyDB: An experimentally supported small interfering RNA efficacy database. [PDF]
IET Syst BiolSmall interfering RNA (siRNA) has revolutionised biomedical research and drug development through precise post‐transcriptional gene silencing technology.
Zhang Y +8 more
europepmc +2 more sources
Small Interfering RNA in Colorectal Cancer Liver Metastasis Therapy. [PDF]
Technol Cancer Res Treat, 2022 Colorectal cancer (CRC) is associated with numerous genetic disorders and cellular abnormalities, and liver metastasis is a common health concern in patients with CRC.
Xie J, Wang S.
europepmc +2 more sources
A small interfering RNA (siRNA) database for SARS-CoV-2. [PDF]
Sci Rep, 2021 Coronavirus disease 2019 (COVID-19) rapidly transformed into a global pandemic, for which a demand for developing antivirals capable of targeting the SARS-CoV-2 RNA genome and blocking the activity of its genes has emerged.
Medeiros IG +5 more
europepmc +2 more sources
Delivery of therapeutic small interfering RNA: The current patent-based landscape. [PDF]
Mol Ther Nucleic Acids, 2022 Implementing small interfering RNA (siRNA) is a promising therapy because it silences disease-related genes theoretically. However, the efficient delivery of siRNA is challenging, which limits its therapeutic applications. Various pharmaceutical delivery
Chen Y +7 more
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