Updates in Small Interfering RNA for the Treatment of Dyslipidemias. [PDF]
Curr Atheroscler Rep, 2023 Abstract Purpose of Review Atherosclerotic cardiovascular disease (ASCVD) is still the leading cause of death worldwide. Despite excellent pharmacological approaches, clinical registries consistently show that many people with dyslipidemia do not achieve optimal management, and many of them are treated with low-intensity
Carugo S +5 more
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Antisense Oligonucleotides and Small Interfering RNA for the Treatment of Dyslipidemias. [PDF]
J Clin Med, 2022 The burden of atherosclerotic disease worldwide necessitates implementing the treatment of its risk factors. Among them, hypercholesterolemia has a central role.
Gareri C +5 more
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An endogenous small interfering RNA pathway in Drosophila [PDF]
Nature, 2008 Drosophila endogenous small RNAs are categorized according to their mechanisms of biogenesis and the Argonaute protein to which they bind. MicroRNAs are a class of ubiquitously expressed RNAs of approximately 22 nucleotides in length, which arise from structured precursors through the action of Drosha-Pasha and Dicer-1-Loquacious complexes.
Manolis Kellis +12 more
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Potential Application of Small Interfering RNA in Gastro-Intestinal Tumors [PDF]
Pharmaceuticals, 2022 Despite the progress made in the diagnoses and therapy of gastrointestinal cancers, these diseases are still plagued by a high mortality. Thus, novel therapeutic approaches are urgently required.
Pasquale Losurdo +10 more
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Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges [PDF]
Journal of Biomedical Science, 2023 RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles extending beyond its applications in vaccines, in which it is used in the response to the COVID-19 pandemic.
Hara Kang +6 more
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siRNAEfficacyDB: An experimentally supported small interfering RNA efficacy database [PDF]
IET Systems BiologySmall interfering RNA (siRNA) has revolutionised biomedical research and drug development through precise post‐transcriptional gene silencing technology.
Yang Zhang +8 more
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Small interfering RNA effect on lipoprotein(a): a systematic review [PDF]
The Egyptian Heart JournalBackground This systematic review investigates the effect of small interfering RNA (siRNA) therapies on lipoprotein(a) [Lp(a)] levels. The purpose is to evaluate the outcomes of recent randomized controlled trials (RCTs) involving siRNA treatments aimed ...
Omar Almaadawy +11 more
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Small Interfering RNA in Colorectal Cancer Liver Metastasis Therapy [PDF]
Technology in Cancer Research & Treatment, 2022 Colorectal cancer (CRC) is associated with numerous genetic disorders and cellular abnormalities, and liver metastasis is a common health concern in patients with CRC.
Junlin Xie MM, Shubin Wang MD
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A small interfering RNA (siRNA) database for SARS-CoV-2 [PDF]
Scientific Reports, 2021 Coronavirus disease 2019 (COVID-19) rapidly transformed into a global pandemic, for which a demand for developing antivirals capable of targeting the SARS-CoV-2 RNA genome and blocking the activity of its genes has emerged.
Inácio Gomes Medeiros +5 more
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Small interfering RNA: From designing to therapeutic in cancer [PDF]
Journal of Genetic Engineering and BiotechnologyCancer has become a significant public health concern worldwide. It is a group of diseases, often resulting from the dysregulation of multiple cellular pathways involved in differentiation, cell proliferation, cell cycle regulation, and DNA repair. These
Jyoti Singh +3 more
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