A small interfering RNA (siRNA) database for SARS-CoV-2 [PDF]
Scientific Reports, 2021 Coronavirus disease 2019 (COVID-19) rapidly transformed into a global pandemic, for which a demand for developing antivirals capable of targeting the SARS-CoV-2 RNA genome and blocking the activity of its genes has emerged.
Inácio Gomes Medeiros +5 more
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Small Interfering RNA Carriers for Oncotherapy: A Preclinical Overview [PDF]
PharmaceuticsIntroduction: Gene therapy using siRNA is a current area of research in oncology. Although siRNA formulations have not yet been approved for cancer therapy, numerous studies have demonstrated their therapeutic potential for tumor remission. Objective: To
Liliana Aranda-Lara +7 more
doaj +2 more sources
Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma [PDF]
World Journal of Gastroenterology, 2015 Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and represents the third leading cause of cancer-related death worldwide.
DAPAS, BARBARA +3 more
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Small interfering RNA: From designing to therapeutic in cancer [PDF]
Journal of Genetic Engineering and BiotechnologyCancer has become a significant public health concern worldwide. It is a group of diseases, often resulting from the dysregulation of multiple cellular pathways involved in differentiation, cell proliferation, cell cycle regulation, and DNA repair. These
Jyoti Singh +3 more
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Small interfering RNA effect on lipoprotein(a): a systematic review [PDF]
The Egyptian Heart JournalBackground This systematic review investigates the effect of small interfering RNA (siRNA) therapies on lipoprotein(a) [Lp(a)] levels. The purpose is to evaluate the outcomes of recent randomized controlled trials (RCTs) involving siRNA treatments aimed ...
Omar Almaadawy +11 more
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siRNAEfficacyDB: An experimentally supported small interfering RNA efficacy database [PDF]
IET Systems BiologySmall interfering RNA (siRNA) has revolutionised biomedical research and drug development through precise post‐transcriptional gene silencing technology.
Yang Zhang +8 more
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Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges [PDF]
Journal of Biomedical Science, 2023 RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles extending beyond its applications in vaccines, in which it is used in the response to the COVID-19 pandemic.
Hara Kang +6 more
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Therapeutic Approaches of Viral Gene Silencing by Small Interfering RNA: Strategies to Prevent the Emergence of Antiviral Resistant Escape Mutants [PDF]
PharmaceuticalsRNA interference (RNAi) was originally regarded as a mechanism of eukaryotic post-transcriptional gene regulation mediated by small interfering RNA (siRNA)-induced sequence-specific RNA degradation.
Hara Kang +6 more
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Delivering Small Interfering RNA for Novel Therapeutics [PDF]
, 2008 The gene silencing capability of RNA interference (RNAi) is being used to study individual gene's biological function and role in biochemical pathways. However, the efficacy of RNAi depends upon efficient delivery of the intermediates of RNAi, small interfering RNA (siRNA) oligonucleotides.
Patrick Lu, Martin C. Woodle
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Small Interfering RNA (siRNA) in Dyslipidemia: A Systematic Review on Safety and Efficacy of siRNA [PDF]
Journal of Experimental PharmacologySai Santhosha Mrudula Alla,1 Dhruv Jayeshkumar Shah,2 Shourya Meyur,3 Pahel Agarwal,4 Deekshitha Alla,1 Sai Lokesh Moraboina,5 Gayatri Vijay Ghadvaje,6 Ruth Getaneh Bayeh,7 Aparna Malireddi,1 Tess Shajan,8 Bodipudi Vineetha,5 Thalvayapati Sai Prudhvi,9 ...
Alla SSM +12 more
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