Small Interfering RNA for Gliomas Treatment: Overcoming Hurdles in Delivery [PDF]
Frontiers in Cell and Developmental Biology, 2022 Gliomas are central nervous system tumors originating from glial cells, whose incidence and mortality rise in coming years. The current treatment of gliomas is surgery combined with chemotherapy or radiotherapy. However, developing therapeutic resistance
Xin-Qi Teng +7 more
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Phenotypic Alteration of BMDM In Vitro Using Small Interfering RNA [PDF]
Cells, 2022 Autologous macrophage transfer is an emerging platform for cell therapy. It is anticipated that conventional macrophage reprogramming based on ex vivo polarization using cytokines and ligands of TLRs may enhance the therapeutic effect.
Noreen Halimani +11 more
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ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway [PDF]
Cell, 2001 Antti Nykänen +2 more
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PLoS Biology, 2003 Heritable, but reversible, changes in transposable element activity were first observed in maize by Barbara McClintock in the 1950s. More recently, transposon silencing has been associated with DNA methylation, histone H3 lysine-9 methylation (H3mK9 ...
Zachary B. Lippman +4 more
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Delivery of therapeutic small interfering RNA: The current patent-based landscape [PDF]
Molecular Therapy: Nucleic Acids, 2022 Implementing small interfering RNA (siRNA) is a promising therapy because it silences disease-related genes theoretically. However, the efficient delivery of siRNA is challenging, which limits its therapeutic applications. Various pharmaceutical delivery
Yu Chen +7 more
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Recognition of small interfering RNA by a viral suppressor of RNA silencing [PDF]
Nature, 2003 RNA silencing (also known as RNA interference) is a conserved biological response to double-stranded RNA that regulates gene expression, and has evolved in plants as a defence against viruses. The response is mediated by small interfering RNAs (siRNAs), which guide the sequence-specific degradation of cognate messenger RNAs.
Dinshaw J. Patel +2 more
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Small Interfering RNA (siRNA) in Dyslipidemia: A Systematic Review on Safety and Efficacy of siRNA [PDF]
Journal of Experimental PharmacologySai Santhosha Mrudula Alla,1 Dhruv Jayeshkumar Shah,2 Shourya Meyur,3 Pahel Agarwal,4 Deekshitha Alla,1 Sai Lokesh Moraboina,5 Gayatri Vijay Ghadvaje,6 Ruth Getaneh Bayeh,7 Aparna Malireddi,1 Tess Shajan,8 Bodipudi Vineetha,5 Thalvayapati Sai Prudhvi,9 ...
Alla SSM +12 more
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Cholesterol Conjugates of Small Interfering RNA: Linkers and Patterns of Modification [PDF]
MoleculesCholesterol siRNA conjugates attract attention because they allow the delivery of siRNA into cells without the use of transfection agents. In this study, we compared the efficacy and duration of silencing induced by cholesterol conjugates of selectively ...
Ivan V. Chernikov +6 more
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Gauging LengthRecognition of Small Interfering RNAs
Structure, 2004 The first crystal structures of small interfering RNA (siRNA)-protein complexes revealed an elegant caliper-like principle of length selection of siRNAs.
H PARK, H WU
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Small Interfering RNA Therapeutics in Hypertension: A Viewpoint on Vasopressor and Vasopressor‐Sparing Strategies for Counteracting Blood Pressure Lowering by Angiotensinogen–Targeting Small Interfering RNA [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Priyanga Ranasinghe +2 more
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