Results 11 to 20 of about 543,226 (367)

An endogenous small interfering RNA pathway in Drosophila [PDF]

Nature, 2008
Drosophila endogenous small RNAs are categorized according to their mechanisms of biogenesis and the Argonaute protein to which they bind. MicroRNAs are a class of ubiquitously expressed RNAs of 22 nucleotides in length, which arise from structured ...
A Eulalio, A Stark, AA Aravin, Alexander Stark, AM Denli, Benjamin Czech, C Klattenhoff, Catherine Schlingeheyde, Colin D. Malone, D Galiana-Arnoux, E Allen, E Bernstein, E Yigit, F Jiang, Gregory J. Hannon, J Brennecke, J Jurka, J Pak, J Rehwinkel, James A. Wohlschlegel, JG Ruby, JG Ruby, Julius Brennecke, K Forstemann, K Forstemann, K Okamura, K Saito, K Saito, LS Gunawardane, Manolis Kellis, Monica Dus, N Bushati, Norbert Perrimon, Q Liu, Ravi Sachidanandam, Rui Zhou, T Sijen, VV Vagin, XH Wang, Y Lee, Y Tomari, YS Lee   +41 more
core   +7 more sources

Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma [PDF]

World Journal of Gastroenterology, 2015
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and represents the third leading cause of cancer-related death worldwide.
DAPAS, BARBARA, FARRA, ROSSELLA, GRASSI, GABRIELE, GRASSI, Mario   +3 more
core   +6 more sources

ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway [PDF]

Cell, 2001
Antti Nykänen, Benjamin Haley, Phillip D. Zamore   +2 more
openalex   +2 more sources

Recognition of small interfering RNA by a viral suppressor of RNA silencing [PDF]

Nature, 2003
RNA silencing (also known as RNA interference) is a conserved biological response to double-stranded RNA that regulates gene expression, and has evolved in plants as a defence against viruses. The response is mediated by small interfering RNAs (siRNAs), which guide the sequence-specific degradation of cognate messenger RNAs.
K. Ye, L. Malinina, D. Patel
semanticscholar   +4 more sources

Small Interfering RNA (siRNA) in Dyslipidemia: A Systematic Review on Safety and Efficacy of siRNA [PDF]

Journal of Experimental Pharmacology
Sai Santhosha Mrudula Alla,1 Dhruv Jayeshkumar Shah,2 Shourya Meyur,3 Pahel Agarwal,4 Deekshitha Alla,1 Sai Lokesh Moraboina,5 Gayatri Vijay Ghadvaje,6 Ruth Getaneh Bayeh,7 Aparna Malireddi,1 Tess Shajan,8 Bodipudi Vineetha,5 Thalvayapati Sai Prudhvi,9 ...
Alla SSM, Shah DJ, Meyur S, Agarwal P, Alla D, Moraboina SL, Ghadvaje GV, Bayeh RG, Malireddi A, Shajan T, Vineetha B, Sai Prudhvi T, Biziyaremye P   +12 more
doaj   +1 more source

Updates in Small Interfering RNA for the Treatment of Dyslipidemias. [PDF]

Curr Atheroscler Rep, 2023
Abstract Purpose of Review Atherosclerotic cardiovascular disease (ASCVD) is still the leading cause of death worldwide. Despite excellent pharmacological approaches, clinical registries consistently show that many people with dyslipidemia do not achieve optimal management, and many of them are treated with low-intensity
Carugo S, Sirtori CR, Gelpi G, Corsini A, Tokgozoglu L, Ruscica M.   +5 more
europepmc   +3 more sources

Antisense Oligonucleotides and Small Interfering RNA for the Treatment of Dyslipidemias. [PDF]

J Clin Med, 2022
The burden of atherosclerotic disease worldwide necessitates implementing the treatment of its risk factors. Among them, hypercholesterolemia has a central role.
Gareri C, Polimeni A, Giordano S, Tammè L, Curcio A, Indolfi C.   +5 more
europepmc   +2 more sources

Small Interfering RNA Therapeutics in Hypertension: A Viewpoint on Vasopressor and Vasopressor‐Sparing Strategies for Counteracting Blood Pressure Lowering by Angiotensinogen–Targeting Small Interfering RNA [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Priyanga Ranasinghe, Melisande L. Addison, David J. Webb   +2 more
doaj   +2 more sources

Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease.

New England Journal of Medicine, 2022
BACKGROUND Lipoprotein(a) is a presumed risk factor for atherosclerotic cardiovascular disease. Olpasiran is a small interfering RNA that reduces lipoprotein(a) synthesis in the liver. METHODS We conducted a randomized, double-blind, placebo-controlled,
M. O’Donoghue, R. Rosenson, B. Gencer, J. A. López, N. Lepor, S. Baum, Elmer Stout, D. Gaudet, B. Knusel, J. Kuder, Xinhui Ran, S. Murphy, Hong Wang, You Wu, H. Kassahun, M. Sabatine   +15 more
semanticscholar   +1 more source

Potential of siRNA in COVID-19 therapy: Emphasis on in silico design and nanoparticles based delivery

Frontiers in Bioengineering and Biotechnology, 2023
Small interfering RNA (siRNA)-mediated mRNA degradation approach have imparted its eminence against several difficult-to-treat genetic disorders and other allied diseases.
Rushikesh Fopase, Chinmaya Panda, Amarnath P. Rajendran, Hasan Uludag, Hasan Uludag, Hasan Uludag, Lalit M. Pandey   +6 more
doaj   +1 more source