Results 11 to 20 of about 417,785 (310)
Cholesterol Conjugates of Small Interfering RNA: Linkers and Patterns of Modification. [PDF]
MoleculesCholesterol siRNA conjugates attract attention because they allow the delivery of siRNA into cells without the use of transfection agents. In this study, we compared the efficacy and duration of silencing induced by cholesterol conjugates of selectively ...
Chernikov IV +6 more
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Small Interfering RNA Therapeutics in Hypertension: A Viewpoint on Vasopressor and Vasopressor-Sparing Strategies for Counteracting Blood Pressure Lowering by Angiotensinogen-Targeting Small Interfering RNA. [PDF]
J Am Heart Assoc, 2022 Ranasinghe P, Addison ML, Webb DJ.
europepmc +2 more sources
Gauging LengthRecognition of Small Interfering RNAs
Structure, 2004 The first crystal structures of small interfering RNA (siRNA)-protein complexes revealed an elegant caliper-like principle of length selection of siRNAs.
H PARK, H WU
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Frontiers in Bioengineering and Biotechnology, 2023 Small interfering RNA (siRNA)-mediated mRNA degradation approach have imparted its eminence against several difficult-to-treat genetic disorders and other allied diseases.
Rushikesh Fopase +6 more
doaj +1 more source
Frontiers in Bioinformatics, 2022 The enzyme Dicer is a component of many small RNA (sRNA) pathways involved in RNA processing for post-transcriptional regulation, anti-viral response and control of transposable elements.
Ben Murcott +5 more
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Small interfering RNAs in tendon homeostasis
British Medical Bulletin, 2021 Abstract Background Tenogenesis and tendon homeostasis are guided by genes encoding for the structural molecules of tendon fibres. Small interfering RNAs (siRNAs), acting on gene regulation, can therefore participate in the process of tendon healing ...
Nicola Maffulli +6 more
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Therapeutic Interfering Particles Exploiting Viral Replication and Assembly Mechanisms Show Promising Performance: A Modelling Study [PDF]
Scientific Reports, 11, 23847 (2021), 2021 Defective interfering particles arise spontaneously during a viral infection as mutants lacking essential parts of the viral genome. Their ability to replicate in the presence of the wild-type (WT) virus (at the expense of viable viral particles) is mimicked and exploited by therapeutic interfering particles.
arxiv +1 more source
Small interfering RNA inhibition of Andes virus replication. [PDF]
PLoS ONE, 2014 Andes virus (ANDV) is the most common causative agent of hantavirus pulmonary syndrome (HPS) in the Americas, and is the only hantavirus associated with human-to-human transmission. Case fatality rates of ANDV-induced HPS are approximately 40%. There are
Cheng-Feng Chiang +3 more
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Polymers in Small-Interfering RNA Delivery [PDF]
Oligonucleotides, 2011 This review will cover the current strategies that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic-co-glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and polymers-containing different nanoparticles.
Singha, K, Namgung, R, Kim, WJ
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Therapeutic opportunities of small interfering RNA [PDF]
Fundamental & Clinical Pharmacology, 2009 AbstractFormation of small interfering RNA (siRNA) occurs in two steps involving binding of the RNA nucleases to a large double‐stranded RNA (dsRNA) and its cleavage into fragments called siRNA. In the second step, these siRNAs join a multinuclease complex, which degrades the homologous single‐stranded mRNAs.
Shraddha V. Bhadada +3 more
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