Results 21 to 30 of about 411,003 (327)

Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease.

New England Journal of Medicine, 2022
BACKGROUND Lipoprotein(a) is a presumed risk factor for atherosclerotic cardiovascular disease. Olpasiran is a small interfering RNA that reduces lipoprotein(a) synthesis in the liver. METHODS We conducted a randomized, double-blind, placebo-controlled,
M. O’Donoghue, R. Rosenson, B. Gencer, J. A. López, N. Lepor, S. Baum, Elmer Stout, D. Gaudet, B. Knusel, J. Kuder, Xinhui Ran, S. Murphy, Hong Wang, You Wu, H. Kassahun, M. Sabatine   +15 more
semanticscholar   +1 more source

Potential of siRNA in COVID-19 therapy: Emphasis on in silico design and nanoparticles based delivery

Frontiers in Bioengineering and Biotechnology, 2023
Small interfering RNA (siRNA)-mediated mRNA degradation approach have imparted its eminence against several difficult-to-treat genetic disorders and other allied diseases.
Rushikesh Fopase, Chinmaya Panda, Amarnath P. Rajendran, Hasan Uludag, Hasan Uludag, Hasan Uludag, Lalit M. Pandey   +6 more
doaj   +1 more source

stepRNA: Identification of Dicer cleavage signatures and passenger strand lengths in small RNA sequences

Frontiers in Bioinformatics, 2022
The enzyme Dicer is a component of many small RNA (sRNA) pathways involved in RNA processing for post-transcriptional regulation, anti-viral response and control of transposable elements.
Ben Murcott, Rebecca J. Pawluk, Anna V. Protasio, Ruth Y. Akinmusola, Dominika Lastik, Vicky L. Hunt   +5 more
doaj   +1 more source

Small interfering RNAs in tendon homeostasis

British Medical Bulletin, 2021
Abstract Background Tenogenesis and tendon homeostasis are guided by genes encoding for the structural molecules of tendon fibres. Small interfering RNAs (siRNAs), acting on gene regulation, can therefore participate in the process of tendon healing ...
Nicola Maffulli, Giuseppe Gargano, Giuseppe Gargano, Francesco Oliva, Francesco Oliva, Antonio Oliviero, Antonio Oliviero   +6 more
openaire   +3 more sources

Small interfering RNA: Discovery, pharmacology and clinical development—An introductory review

British Journal of Pharmacology, 2022
Post‐transcriptional gene silencing targets and degrades mRNA transcripts, silencing the expression of specific genes. RNA interference technology, using synthetic structurally well‐defined short double‐stranded RNA (small interfering RNA [siRNA]), has ...
P. Ranasinghe, M. Addison, J. Dear, David J. Webb   +3 more
semanticscholar   +1 more source

Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage

Nature Biomedical Engineering, 2021
The progression of osteoarthritis is associated with inflammation triggered by the enzymatic degradation of extracellular matrix in injured cartilage. Here we show that a locally injected depot of nanoparticles functionalized with an antibody targeting ...
Sean K. Bedingfield, J. Colazo, Fang Yu, Danielle D. Liu, Meredith A. Jackson, L. Himmel, Hongsik Cho, L. Crofford, K. Hasty, C. Duvall   +9 more
semanticscholar   +1 more source

Small interfering RNA inhibition of Andes virus replication. [PDF]

PLoS ONE, 2014
Andes virus (ANDV) is the most common causative agent of hantavirus pulmonary syndrome (HPS) in the Americas, and is the only hantavirus associated with human-to-human transmission. Case fatality rates of ANDV-induced HPS are approximately 40%. There are
Cheng-Feng Chiang, Cesar G Albariňo, Michael K Lo, Christina F Spiropoulou   +3 more
doaj   +1 more source

Polymers in Small-Interfering RNA Delivery [PDF]

Oligonucleotides, 2011
This review will cover the current strategies that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic-co-glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and polymers-containing different nanoparticles.
Singha, K, Namgung, R, Kim, WJ
openaire   +4 more sources

Therapeutic opportunities of small interfering RNA [PDF]

Fundamental & Clinical Pharmacology, 2009
AbstractFormation of small interfering RNA (siRNA) occurs in two steps involving binding of the RNA nucleases to a large double‐stranded RNA (dsRNA) and its cleavage into fragments called siRNA. In the second step, these siRNAs join a multinuclease complex, which degrades the homologous single‐stranded mRNAs.
Shraddha V. Bhadada, Mithil Soni, Mayur M. Patel, Bhoomika R Goyal   +3 more
openaire   +3 more sources

Small interfering RNAs in the management of human osteoporosis

British Medical Bulletin, 2023
Abstract Background Osteoporosis results in reduced bone mass and consequent bone fragility. Small interfering RNAs (siRNAs) can be used for therapeutic purposes, as molecular targets or as useful markers to test new therapies. Sources of data
Giuseppe Gargano, Giovanni Asparago, Filippo Spiezia, Nicola Maffulli, Francesco Oliva   +4 more
openaire   +3 more sources