Results 21 to 30 of about 352,358 (326)

Medicinal Chemistry of Oligonucleotide Drugs - Milestones of the Past and Visions for the Future

CHIMIA, 2022
The oligonucleotide therapeutics field has blossomed in recent years, with thirteen approved drugs today and the promise of accelerated growth in coming years.
Jonathan Hall, Anastasia Ashkinadze, Jan Philipp Becker, Artur Laski, Eva-Maria Manz, Štefan Moravčík, Sebastian Sjöström, Mathilde Vincent   +7 more
doaj   +1 more source

Traffic into silence: endomembranes and post-transcriptional RNA silencing. [PDF]

, 2014
microRNAs (miRNAs) and small interfering RNAs (siRNAs) are small RNAs that repress gene expression at the post-transcriptional level in plants and animals. Small RNAs guide Argonaute-containing RNA-induced silencing complexes to target RNAs in a sequence-
Chen, Xuemei, Kim, Yun Ju, Maizel, Alexis   +2 more
core   +3 more sources

Recent studies on non-coding small RNAs in plants

浙江大学学报. 农业与生命科学版, 2014
There are many non-coding small RNAs in plants and animals, which regulate gene expression via direct cleavage of target mRNAs or via inhibition of translation at the post-transcriptional level.
Shen Enhui, Liu Yang, Ye Chuyu, Fan Longjiang   +3 more
doaj   +1 more source

A small RNA response at DNA ends in Drosophila [PDF]

, 2012
Small RNAs have been implicated in numerous cellular processes, including effects on chromatin structure and the repression of transposons. We describe the generation of a small RNA response at DNA ends in Drosophila that is analogous to the recently ...
Böttcher, Romy, Förstemann, Klaus, Michalik, Katharina M.   +2 more
core   +1 more source

Small interfering RNA against BCR-ABL transcripts sensitize mutated T315I cells to nilotinib

Haematologica, 2010
Background Selective inhibition of the BCR-ABL tyrosine kinase by RNA interference has been demonstrated in leukemic cells. We, therefore, evaluated specific BCR-ABL small interfering RNA silencing in BCR-ABL-positive cell lines, including those ...
Michael Koldehoff, Lambros Kordelas, Dietrich W. Beelen, Ahmet H. Elmaagacli   +3 more
doaj   +1 more source

An influenza virus-inspired polymer system for the timed release of siRNA [PDF]

, 2013
Small interfering RNA silences specific genes by interfering with mRNA translation, and acts to modulate or inhibit specific biological pathways; a therapy that holds great promise in the cure of many diseases. However, the naked small interfering RNA is
A Fire, A Turchinovich, AD Judge, AJ Convertine, B Ozpolat, BM Rosen, C Pichon, C Pichon, C Plank, D Smith, DL McKenzie, DV Schaffer, DW Pack, EM Saurer, F Yamauchi, I Le Blanc, I Prasadam, J Soutschek, K Miyata, KA Whitehead, KF Ren, L Dieguez, M Kurisawa, ME Davis, NP Truong, NP Truong, P Midoux, RG Handwerger, RKM Leung, S Dincer, S Mehrotra, S Wu, SB Zhang, T Lammers, TS Zimmermann, V Percec, YW Cho, ZF Duan   +37 more
core   +2 more sources

Transfer RNA-derived small RNAs in the cancer transcriptome [PDF]

, 2016
The cellular lifetime includes stages such as differentiation, proliferation, division, senescence and apoptosis.These stages are driven by a strictly ordered process of transcription dynamics.
A Dueck, A Sobala, AE Hall, AM Burroughs, C Cole, C Fricke, D Green, D Haussecker, D Kim, Darrell Green, DM Thompson, DP Bartel, DR Rhodes, FE Nicolas, GL Hager, H Fu, H Goodarzi, I Salaverria, JM Perkel, M Ghildiyal, M Talpaz, MS Pagter de, NC Schopman, O Rechavi, P Adjibade, P Ivanov, P Kumar, P Kumar, Q Wang, R Levitz, RL Maute, S Yamasaki, SC Stearns, T Uchiumi, Tamas Dalmay, U Harms, William D. Fraser, YS Lee, Z Li   +38 more
core   +1 more source

An endogenous small interfering RNA pathway in Drosophila [PDF]

, 2008
Drosophila endogenous small RNAs are categorized according to their mechanisms of biogenesis and the Argonaute protein to which they bind. MicroRNAs are a class of ubiquitously expressed RNAs of 22 nucleotides in length, which arise from structured ...
A Eulalio, A Stark, AA Aravin, Alexander Stark, AM Denli, Benjamin Czech, C Klattenhoff, Catherine Schlingeheyde, Colin D. Malone, D Galiana-Arnoux, E Allen, E Bernstein, E Yigit, F Jiang, Gregory J. Hannon, J Brennecke, J Jurka, J Pak, J Rehwinkel, James A. Wohlschlegel, JG Ruby, JG Ruby, Julius Brennecke, K Forstemann, K Forstemann, K Okamura, K Saito, K Saito, LS Gunawardane, Manolis Kellis, Monica Dus, N Bushati, Norbert Perrimon, Q Liu, Ravi Sachidanandam, Rui Zhou, T Sijen, VV Vagin, XH Wang, Y Lee, Y Tomari, YS Lee   +41 more
core   +1 more source

Polymers in Small-Interfering RNA Delivery [PDF]

Oligonucleotides, 2011
This review will cover the current strategies that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic- co -glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and polymers ...
Singha, K, Namgung, R, Kim, WJ
openaire   +3 more sources

Therapeutic opportunities of small interfering RNA [PDF]

Fundamental & Clinical Pharmacology, 2009
AbstractFormation of small interfering RNA (siRNA) occurs in two steps involving binding of the RNA nucleases to a large double‐stranded RNA (dsRNA) and its cleavage into fragments called siRNA. In the second step, these siRNAs join a multinuclease complex, which degrades the homologous single‐stranded mRNAs.
Bhoomika R, Goyal, Mayur M, Patel, Mithil K, Soni, Shraddha V, Bhadada   +3 more
openaire   +2 more sources