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RNA Interference and Small Interfering RNAs
ChemBioChem, 2001The term aRNA interferenceo (RNAi) was coined after the groundbreaking discovery that injection of double-stranded RNA (dsRNA) into the nematode Caenorhabditis elegans leads to specific silencing of genes highly homologous in sequence to the delivered dsRNA.
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The Role of Small Interfering RNAs in Hepatocellular Carcinoma
Journal of Gastrointestinal Cancer, 2023Hepatocellular carcinoma (HCC), a primary liver cancer with high mortality, is the most common malignant tumor in the world. Currently, the effect of routine treatment is poor, especially for this kind of cancer with strong heterogeneity and late detection.
Feng, Chen +4 more
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Small interfering RNA (siRNA)-based therapeutics
Drug and Therapeutics Bulletin, 2023In early studies in simple organisms and mammalian cell lines, small interfering RNA (siRNA) molecules were found to allow experimental cleavage of intracellular messenger RNA (mRNA; the transcription product of a cell gene), reducing the levels of the proteins that would otherwise be formed by the action of the mRNA, thereby ‘silencing’ a specific ...
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Small Interfering RNAs and RNA Therapeutics in Cardiovascular Diseases
2020Ribonucleic acid (RNA) is being exploited and understood in its many aspects of function and structure for development of valuable tools in the therapeutics of various diseases such as cardiovascular etc. The expanded knowledge regarding function of RNA in the genomics and inside the cell has dramatically changed the therapeutic strategies in the past ...
Parveen, Bansal, Malika, Arora
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RNA interference and chemically modified small interfering RNAs
Current Opinion in Chemical Biology, 2004RNA interference (RNAi) is a powerful biological process for specific silencing of gene expression in diversified eukaryotic cells and has tremendous potential for functional genomics, drug discovery through in vivo target validation, and development of novel gene-specific medicine.
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Derivation and function of small interfering RNAs and microRNAs
Virus Research, 2004Small interfering RNA (siRNA) duplexes are generally produced by Dicer cleavage of double-stranded RNAs of frequently exogenous origin and can induce the cleavage and degradation of mRNAs bearing an identical sequence. In contrast, microRNAs (miRNAs) are encoded within the eukaryotic genome as short RNA hairpin structures.
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Photocaged Small Interfering RNA
Russian Journal of Bioorganic Chemistry, 2022E. A. Akhmetova +4 more
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On the delivery of small interfering RNAs into mammalian cells
Expert Opinion on Drug Delivery, 2005RNA interference is becoming the technique of choice for analysing gene function and drug target validation. In this process, sequence-specific gene inhibition is initiated by small RNA duplexes, known as small interfering RNAs (siRNAs). The possibility that exogenously delivered siRNAs or endogenously expressed hairpin siRNAs can cause the destruction
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Modulation of Noncoding RNAs (ncRNAs) and Their Potential Role as Therapeutics
Medical Epigenetics, 2021Luciano Pirola +2 more
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Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease
New England Journal of Medicine, 2022You Wu, Helinä Kassahun, Huei Wang
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