Results 71 to 80 of about 5,655,190 (291)

Virus-derived small interfering RNAs serve as new intercellular immune modulators against viral infection in mammals [PDF]

ExRNA
RNA silencing serves as the primary antiviral immune system in plants, fungi, and invertebrates. Upon virus invasion, its replication intermediates act as pathogen-associated molecular patterns (PAMPs), promptly recognized and processed by Dicer into ...
Shengkai Zhou, Ye Xu, Yu Zhou, Fangfang Jin   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

HIV-1 Tat interaction with Dicer: requirement for RNA

Retrovirology, 2006
Dicer is an RNase III which processes two classes of cellular small RNAs: the microRNAs (miRNA) and short interfering RNAs (siRNA). Previously, we observed that over-expressed HIV-1 Tat protein can suppress the processing of small RNAs inside cells. Here,
Jeang Kuan-Teh, Bennasser Yamina
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Small Nucleolar RNAs: Identification, Structure, and Function

, 2006
The revelation in the last few years of a large number of new noncoding RNAs (ncRNAs) has revolutionized our view of how gene regulation works. This is to a large extent due to the recent advances in computational as well as experimental methodology ...
Söderbom, Fredrik,, Fredrik Söderbom
core   +1 more source

Gene silencing by small RNAs in plants

, 2022
The phenomenon of gene silencing by small non-coding RNAs, i.e., small interfering RNA (siRNA) and microRNA (miRNA) has becoming as one of potential approaches for crop improvement.
Chandana, B. S 1* And Ramachandra, V 2
core   +1 more source

A High Resolution Short Interfering RNA (siRNA) Detection Method from Virus-infected Plants

Bio-Protocol, 2013
Plant viruses are strong inducers as well as targets of RNA silencing. In plants RNA silencing acts as a natural defense mechanism against viral infection and is associated with accumulation of virus-specific small interfering RNAs (siRNAs).
Vinay Panwar, Guus Bakkeren
doaj   +1 more source

Updates in Small Interfering RNA for the Treatment of Dyslipidemias

Current Atherosclerosis Reports, 2023
Abstract Purpose of Review Atherosclerotic cardiovascular disease (ASCVD) is still the leading cause of death worldwide. Despite excellent pharmacological approaches, clinical registries consistently show that many people with dyslipidemia do not achieve optimal management, and many of them are treated with low-intensity
Carugo, S., Sirtori, C. R., Gelpi, G., Corsini, A., Tokgozoglu, L., Ruscica, M.   +5 more
openaire   +3 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Molecular genetic analysis of siRNA biogenesis and function in Arabidopsis thaliana [PDF]

, 2009
In diverse eukaryotes, small RNA products of Dicer-like (DCL) proteins regulate mRNA stability or translation, and direct chromatin modifications to genomic regions, phenomena collectively known as RNA silencing.
Blevins, Todd Lucas
core   +1 more source