Results 91 to 100 of about 5,655,190 (291)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

FungiSNC: An integrated database for fungi small non-coding RNAs based on high-throughput sequencing

Journal of Advanced Research
Introduction: Small non-coding RNAs (sncRNAs) have been proven to play crucial roles in various biological processes such as development, stress responses, virulence, and pathogenicity.
Xiaoqiang Lang, Jinjing Luo, Fazhi Li, Jie Zeng, Guoxian Liu, ChunYan Yu, Yihan Guo, Hui Xu, Qi Liu, Yi Cao   +9 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Functions of small RNAs in mosquitoes

, 2016
The role of small noncoding RNAs in regulating gene expression and as a consequence their connection with most cellular pathways is becoming increasingly recognized.
M. Hussain, S. Asgari, Etebari, K., K. Etebari, Hussain, M., Asgari, S.   +5 more
core   +1 more source

Expression of mouse small interfering RNAs in lettuce using artificial microRNA technology

BioTechniques, 2020
Artificial miRNA technology enables the generation of siRNAs to regulate the expression of targeted genes. However, the application of siRNAs to alter gene expression is challenging due to their instability and requires a means to efficiently deliver ...
Tayebeh Kakeshpour, Tej Man Tamang, Woojun D Park, Murli Manohar, Jian Yang, Kendal D Hirschi, Sunghun Park   +6 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Chemical modification patterns compatible with high potency dicer-substrate small interfering RNAs

, 2008
Dicer-substrate small interfering RNAs (DsiRNAs) are synthetic RNA duplexes that are processed by Dicer into 21-mer species and show improved potency as triggers of RNA interference, particularly when used at low dose. Chemical modification patterns that
Hillier, Chris, Rose, Scott D., Amarzguioui, Mohammad, Rossi, John J., Soifer, Harris S., Wiiger, Merete T., Collingwood, Michael A., Huang, Lingyan, Behlke, Mark A.   +8 more
core   +1 more source

Presence and function of small RNAs during plant reproduction

RNA Biology
Plants possess an expansive suite of epigenetic control mechanisms to keep their large, repetitive, and unruly genomes in check. Small non-coding RNAs constitute one such mechanism by directing transcriptional and post-transcriptional gene silencing ...
Ann S. Yang, Alexander M. Tang, Mary Gehring   +2 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Delivering Small Interfering RNA for Novel Therapeutics [PDF]

, 2008
The gene silencing capability of RNA interference (RNAi) is being used to study individual gene's biological function and role in biochemical pathways. However, the efficacy of RNAi depends upon efficient delivery of the intermediates of RNAi, small interfering RNA (siRNA) oligonucleotides.
Lu, Patrick Y., Woodle, Martin C.
openaire   +2 more sources