EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer
Advanced Science, EarlyView.This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv +8 more
wiley +1 more source
TFIIIC Localizes Budding Yeast ETC Sites to the Nuclear Periphery [PDF]
, 2012 Peer reviewedPublisher ...
Botsios, Sotirios +3 more
core +2 more sources
Nanoscale Mapping of the Subcellular Glycosylation Landscape
Advanced Science, EarlyView.Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter +4 more
wiley +1 more source
Mapping targets for small nucleolar RNAs in yeast [PDF]
Wellcome Open Research, 2018 Background: Recent analyses implicate changes in the expression of the box C/D class of small nucleolar RNAs (snoRNAs) in several human diseases. Methods: Here we report the identification of potential novel RNA targets for box C/D snoRNAs in budding yeast, using the approach of UV crosslinking and sequencing of hybrids (CLASH) with the snoRNP proteins
Tatiana Dudnakova +3 more
openaire +2 more sources
Mechanisms for hypoxia-induced long non-coding small nucleolar RNA host gene 14 in promoting temozolomide resistance of glioma. [PDF]
, 2022 Haiting Zhao +6 more
openalex +1 more source
Nucleolar integrity during interphase supports faithful Cdk1 activation and mitotic entry [PDF]
, 2018 The nucleolus is a dynamic nuclear body that has been demonstrated to disassemble at the onset of mitosis; the relationship between cell cycle progression and nucleolar integrity, however, remains poorly understood.
Fujimura Akiko +6 more
core +2 more sources
Advanced Science, EarlyView.This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang +11 more
wiley +1 more source
snOPY: a small nucleolar RNA orthological gene database [PDF]
BMC Research Notes, 2013 Abstract Background Small nucleolar RNAs (snoRNAs) are a class of non-coding RNAs that guide the modification of specific nucleotides in ribosomal RNAs (rRNAs) and small nuclear RNAs (snRNAs). Although most non-coding RNAs undergo post-transcriptional modifications prior to maturation, the functional significance of ...
Yoshihama, Maki +2 more
openaire +2 more sources
snR30/U17 Small Nucleolar Ribonucleoprotein: A Critical Player during Ribosome Biogenesis
Cells, 2020 The small nucleolar RNA snR30 (U17 in humans) plays a unique role during ribosome synthesis. Unlike most members of the H/ACA class of guide RNAs, the small nucleolar ribonucleoprotein (snoRNP) complex assembled on snR30 does not direct pseudouridylation
Timothy John Vos, Ute Kothe
doaj +1 more source
Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors [PDF]
, 2014 Ribosome biogenesis is a key process for maintaining protein synthetic capacity in dividing or growing cells, and requires coordinated production of ribosomal proteins and ribosomal RNA (rRNA), including the processing of the latter.
Arora +68 more
core +6 more sources