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RNA Interference and Small Interfering RNAs
ChemBioChem, 2001The term aRNA interferenceo (RNAi) was coined after the groundbreaking discovery that injection of double-stranded RNA (dsRNA) into the nematode Caenorhabditis elegans leads to specific silencing of genes highly homologous in sequence to the delivered dsRNA.
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Transfer RNA-derived small RNAs in plants
Science China Life Sciences, 2017Rather than random degradation products, the 18 to 40 nucleotides (nt) transfer RNA-derived small RNAs (tsRNAs) are RNA species generated specifically from pre-RNAs or mature tRNAs in archaea, bacteria and eukaryotes. Recent studies from animal systems have shown that tsRNAs are important non-coding RNAs that regulate gene expression at the ...
Lei, Zhu, David W, Ow, Zhicheng, Dong
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Identification of Bacterial Small RNAs by RNA Sequencing
2014Small regulatory RNAs (sRNAs) in bacteria are known to modulate gene expression and control a variety of processes including metabolic reactions, stress responses, and pathogenesis in response to environmental signals. A method to identify bacterial sRNAs on a genome-wide scale based on RNA sequencing (RNA-seq) is described that involves the ...
María, Gómez-Lozano +3 more
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6S RNA: a small RNA regulator of transcription
Current Opinion in Microbiology, 2007Appreciation for the prevalence and diversity of noncoding, small RNAs (sRNAs) has grown enormously in the past decade. A major role for sRNAs in all organisms is to regulate gene expression, often at the level of mRNA translation or stability. However, a few sRNAs have been shown to function by regulating transcription.
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Small RNAs in Germline Development
2013One of the most important and evolutionarily conserved strategies to control gene expression in higher metazoa is posttranscriptional regulation via small regulatory RNAs such as microRNAs (miRNAs), endogenous small interfering RNAs (endo-siRNAs), and piwi-interacting RNAs (piRNAs). Primordial germ cells, which are defined by their totipotent potential
Matthew S, Cook, Robert, Blelloch
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The role of small nuclear RNAs in RNA splicing
Current Opinion in Cell Biology, 1993Recent genetic and biochemical experiments have revealed an intimate and dynamic role for small nuclear RNAs (snRNAs) in multiple steps of RNA-splicing reactions. Both snRNA-substrate and snRNA-snRNA interactions are involved. These interactions concern not only splice site and branch point definition, but also the catalytic reactions of the first and ...
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The Role of Small RNAs in Vaccination
2014The concept of vaccination came to light following Edward Jenner's classical observation on milkmaids who were protected against smallpox. However, plants lack the cellular based immunity system and thus it was not appreciated earlier that plants can also be protected from their pathogens.
Ajeet, Chaudhary, Sunil Kumar, Mukherjee
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Cellular functions of eukaryotic RNA helicases and their links to human diseases
Nature Reviews Molecular Cell Biology, 2023Katherine E Bohnsack +2 more
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