Results 21 to 30 of about 63,544 (259)

Effect of prior immunisation with smallpox vaccine for protection against human Mpox: A systematic review

Reviews in Medical Virology, 2023
Monkeypox is an emerging threat to humans since a new outbreak in May 2022. It is hypothesised that increasing the immunologically naive population after the cessation of the smallpox vaccination campaign in the 1980s is one of the leading causes of it ...
Fahima Akter, Tahira Binte Hasan, Farhana Alam, Aurpy Das, Shanta Afrin, Sadia Maisha, A. Masud, Saif-Ur-Rahman Km   +7 more
semanticscholar   +1 more source

Overview of the regulatory approval of tecovirimat intravenous formulation for treatment of smallpox: potential impact on smallpox outbreak response capabilities, and future tecovirimat development potential

Expert Review of Anti-Infective Therapy, 2023
Introduction Tecovirimat oral capsule formulation is approved in the US and Canada for treatment of smallpox and in the United Kingdom (UK) and European Union (EU) for treatment of multiple human orthopoxvirus diseases, including mpox.
Andrew T. Russo, D. Grosenbach, Kady M. Honeychurch, Paul G Long, D. Hruby   +4 more
semanticscholar   +1 more source

Mpox Outbreak: A Call for Urgent Action and Improved Response Strategies. [PDF]

Health Sci Rep
ABSTRACT Introduction The resurgence of mpox presents a significant global public health challenge, especially in non‐endemic regions. Following its initial global spread in 2022, the current outbreak is driven by a newly emerged Clade I, exhibiting atypical clinical manifestations and altered transmission patterns.
Edward M, Gwanafyo G, Kimambo EA, Basaya D.   +3 more
europepmc   +2 more sources

Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model

Msphere, 2021
Preparedness activities against highly transmissible viruses with high mortality rates have been highlighted during the ongoing coronavirus disease 2019 (COVID-19) pandemic.
C. Hutson, Ashley V Kondas, Mathew R Mauldin, Jeffrey B Doty, I. Grossi, Clint N. Morgan, S. Ostergaard, C. Hughes, Y. Nakazawa, Chantal Kling, Brock E. Martin, J. Ellison, Darin Carroll, Nadia F. Gallardo-Romero, V. Olson   +14 more
semanticscholar   +1 more source

Neurologic Complications of Smallpox and Monkeypox: A Review.

JAMA Neurology, 2022
Importance Orthopox viruses include smallpox virus, a once feared but now eradicated virus, as well as monkeypox virus. Monkeypox is an emerging virus initially isolated in 1958, previously unrecognized outside sub-Saharan Africa until a worldwide ...
B. Billioux, Oliver Tshiani Mbaya, J. Sejvar, A. Nath   +3 more
semanticscholar   +1 more source

Long-term effects of smallpox vaccination on expression of the HIV-1 co-receptor CCR5 in women. [PDF]

PLoS ONE, 2018
BACKGROUND:Smallpox vaccinations were stopped globally in 1980. Recent studies have shown that in women, being smallpox vaccinated was associated with a reduced risk of HIV infection compared with not being smallpox vaccinated.
K B Beck, B L Hønge, J S Olesen, M S Petersen, S Jespersen, C Wejse, Z J da Silva, C Medina, D D S Té, B K Moeller, C S Benn, P Aaby, C Erikstrup   +12 more
doaj   +1 more source

Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox

Viruses, 2021
Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial ...
Reed F. Johnson, Lauren A. Keith, Timothy K. Cooper, Srikanth Yellayi, Nicole M. Josleyn, Krisztina B. Janosko, James D. Pettitt, David Thomasson, Katie R. Hagen, Robin Gross, John G. Bernbaum, Debbie Douglas, Jeffrey Solomon, Mark Martinez, Kurt Cooper, Marisa St. Claire, Danny R. Ragland, Peter B. Jahrling, Jens H. Kuhn, Andrew E. Arai   +19 more
doaj   +1 more source

History of Smallpox

Journal of Nepal Medical Association, 2003
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P N Shrestha
doaj   +1 more source

An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications

Expert Review of Anti-Infective Therapy, 2020
Introduction Tecovirimat (TPOXX®; ST-246) was approved for the treatment of symptomatic smallpox by the USFDA in July of 2018 and has been stockpiled by the US government for use in a smallpox outbreak.
Andrew T. Russo, D. Grosenbach, J. Chinsangaram, Kady M. Honeychurch, Paul G Long, Candace E Lovejoy, B. Maiti, I. Meara, D. Hruby   +8 more
semanticscholar   +1 more source

Remaining Questions about Clinical Variola Major

Emerging Infectious Diseases, 2011
After the recent summary of World Health Organization–authorized research on smallpox, several clinical issues remain. This policy review addresses whether early hemorrhagic smallpox is disseminated intravascular coagulation and speculates about the ...
J. Michael Lane
doaj   +1 more source