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Expert Review of Anti-Infective Therapy, 2023 Introduction Tecovirimat oral capsule formulation is approved in the US and Canada for treatment of smallpox and in the United Kingdom (UK) and European Union (EU) for treatment of multiple human orthopoxvirus diseases, including mpox.
Andrew T. Russo +4 more
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American Journal of Public Health, 1925 DURING THE past few years, health officers have warned the public of the increasing prevalence of smallpox throughout the United States and Canada. The report of the Surgeon General, U. S. Public Health Service, for 1924 stated that smallpox was the most widely distributed plague in the world, and that approximately one-fifth of all the cases of ...
C. C. Pierce
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Msphere, 2021 Preparedness activities against highly transmissible viruses with high mortality rates have been highlighted during the ongoing coronavirus disease 2019 (COVID-19) pandemic.
C. Hutson +14 more
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Neurologic Complications of Smallpox and Monkeypox: A Review.
JAMA Neurology, 2022 Importance Orthopox viruses include smallpox virus, a once feared but now eradicated virus, as well as monkeypox virus. Monkeypox is an emerging virus initially isolated in 1958, previously unrecognized outside sub-Saharan Africa until a worldwide ...
B. Billioux +3 more
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The rediscovery of smallpox [PDF]
Clinical Microbiology and Infection, 2014 Smallpox is an infectious disease that is unique to humans, caused by a poxvirus. It is one of the most lethal of diseases; the virus variant Variola major has a mortality rate of 30%. People surviving this disease have life-long consequences, but also assured immunity. Historically, smallpox was recognized early in human populations.
Thèves, Catherine +2 more
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Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox
Viruses, 2021 Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial ...
Reed F. Johnson +19 more
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An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications
Expert Review of Anti-Infective Therapy, 2020 Introduction Tecovirimat (TPOXX®; ST-246) was approved for the treatment of symptomatic smallpox by the USFDA in July of 2018 and has been stockpiled by the US government for use in a smallpox outbreak.
Andrew T. Russo +8 more
semanticscholar +1 more source
Progression of pathogenic events in cynomolgus macaques infected with variola virus. [PDF]
PLoS ONE, 2011 Smallpox, caused by variola virus (VARV), is a devastating human disease that affected millions worldwide until the virus was eradicated in the 1970 s.
Victoria Wahl-Jensen +10 more
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