Results 31 to 40 of about 63,544 (259)

Progression of pathogenic events in cynomolgus macaques infected with variola virus. [PDF]

PLoS ONE, 2011
Smallpox, caused by variola virus (VARV), is a devastating human disease that affected millions worldwide until the virus was eradicated in the 1970 s.
Victoria Wahl-Jensen, Jennifer A Cann, Kathleen H Rubins, John W Huggins, Robert W Fisher, Anthony J Johnson, Fabian de Kok-Mercado, Thomas Larsen, Jo Lynne Raymond, Lisa E Hensley, Peter B Jahrling   +10 more
doaj   +1 more source

Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age

Science, 2020
Viking smallpox diversity Humans have a notable capacity to withstand the ravages of infectious diseases. Smallpox killed millions of people but drove Jenner's invention of vaccination, which eventually led to the annihilation of this virus, declared in ...
Barbara Mühlemann, L. Vinner, A. Margaryan, H. Wilhelmson, Constanza de la Fuente Castro, M. Allentoft, Peter de Barros Damgaard, A. Hansen, S. Holtsmark Nielsen, L. Strand, Jan Bill, A. Buzhilova, T. Pushkina, Ceri Falys, V. Khartanovich, V. Moiseyev, M. Jørkov, Palle Østergaard Sørensen, Yvonne Magnusson, Ingrid Gustin, H. Schroeder, G. Sutter, Geoffrey L. Smith, C. Drosten, R. Fouchier, Derek J. Smith, E. Willerslev, T. Jones, M. Sikora   +28 more
semanticscholar   +1 more source

Patterns of smallpox mortality in London, England, over three centuries.

PLoS Biology, 2020
Smallpox is unique among infectious diseases in the degree to which it devastated human populations, its long history of control interventions, and the fact that it has been successfully eradicated.
Olga Krylova, David J D Earn
doaj   +1 more source

Drug Development against Smallpox: Present and Future

Antimicrobial Agents and Chemotherapy, 2020
Forty years after the last endemic smallpox case, variola virus (VARV) is still considered a major threat to humans due to its possible use as a bioterrorism agent.
D. Delaune, F. Iseni
semanticscholar   +1 more source

Phase-out of smallpox vaccination and the female/male HIV-1 prevalence ratio: an ecological study from Guinea-Bissau

BMJ Open, 2019
Objective In Guinea-Bissau, West Africa, we observed that having a smallpox vaccination scar was associated with lower HIV-1 prevalence, more strongly for women than men.
Marie Villumsen, Peter Aaby, Amabelia Rodrigues, Andreas Rieckmann, Christine Benn, Bo Langhoff Hønge, Signe Sørup, Zacarias Jose da Silva, Hilton Whittle   +8 more
doaj   +1 more source

Reflections on Dr J Michael Lane, a giant of public health (1936-2020)

Global Biosecurity, 2020
Reflections on Dr J Michael Lane (1936-2020) a global leader in smallpox eradication and the Director of Smallpox Eradication at the US CDC. Dr Lane was an alumnus of the US CDC's Epidemic Intelligence Service and had worked in global health on control ...
C Raina MacIntyre
doaj   +1 more source

Efficacy of CMX001 as a Prophylactic and Presymptomatic Antiviral Agent in New Zealand White Rabbits Infected with Rabbitpox Virus, a Model for Orthopoxvirus Infections of Humans

Viruses, 2011
CMX001, a lipophilic nucleotide analog formed by covalently linking 3‑(hexdecyloxy)propan-1-ol to cidofovir (CDV), is being developed as a treatment for smallpox.
Richard W. Moyer, George Painter, Randall Lanier, Amanda D. Rice, Scott Foster, Bernhard Lampert, Mathew M. Adams, Alice Robertson   +7 more
doaj   +1 more source

Reevaluating the Risk of Smallpox Reemergence.

Military Medicine, 2020
INTRODUCTION Smallpox, caused by variola virus, was eradicated in 1980, but remains a category A bioterrorism agent. A decade ago, smallpox ranked second after anthrax in a multifactorial risk priority scoring analysis of category A bioterrorism agents ...
C. R. MacIntyre, C. R. MacIntyre
semanticscholar   +1 more source

Eczema Herpeticum and Clinical Criteria for Investigating Smallpox

Emerging Infectious Diseases, 2009
Eczema herpeticum can clinically resemble smallpox. On the basis of the algorithm for rapid evaluation of patients with an acute generalized vesiculopustular rash illness, our patient met criteria for high risk for smallpox.
David A. Boyd, Leonard C. Sperling, Scott A. Norton   +2 more
doaj   +1 more source

Oral Tecovirimat for the Treatment of Smallpox

New England Journal of Medicine, 2018
BACKGROUND Smallpox was declared eradicated in 1980, but variola virus (VARV), which causes smallpox, still exists. There is no known effective treatment for smallpox; therefore, tecovirimat is being developed as an oral smallpox therapy.
D. Grosenbach, Kady M. Honeychurch, Eric A. Rose, J. Chinsangaram, Annie E. Frimm, B. Maiti, Candace E Lovejoy, I. Meara, Paul G Long, D. Hruby   +9 more
semanticscholar   +1 more source