Results 41 to 50 of about 63,544 (259)

Monkeypox Goes North: Ongoing Worldwide Monkeypox Infections in Humans

Viruses, 2022
In the late 1970s, global vaccination programs resulted in the eradication of smallpox. The Monkeypox virus (MPXV), which is closely related to the smallpox-inducing variola virus, was previously endemic only in Sub-Saharan Africa but is currently ...
Barbara S. Schnierle
doaj   +1 more source

Phase 3 Efficacy Trial of Modified Vaccinia Ankara as a Vaccine against Smallpox.

New England Journal of Medicine, 2019
BACKGROUND Many countries have stockpiled vaccines because of concerns about the reemergence of smallpox. Traditional smallpox vaccines are based on replicating vaccinia viruses; these vaccines have considerable side effects.
P. Pittman, M. Hahn, Heechoon Lee, Craig D Koca, N. Samy, D. Schmidt, Joachim Hornung, H. Weidenthaler, C. Heery, T. Meyer, G. Silbernagl, J. Maclennan, P. Chaplin   +12 more
semanticscholar   +1 more source

Low-Temperature Multiple Micro-Dispensing on Microneedles for Accurate Transcutaneous Smallpox Vaccination

Vaccines, 2022
Smallpox is an acute contagious disease caused by the variola virus. According to WHO guidelines, the smallpox vaccine is administrated by scarification into the epidermis using a bifurcated needle moistened with a vaccine solution.
Sang-Gu Yim, Yun-Ho Hwang, Seonyeong An, Keum-Yong Seong, Seo-Yeon Kim, Semin Kim, Hyeseon Lee, Kang-Oh Lee, Mi-Young Kim, Dokeun Kim, You-Jin Kim, Seung-Yun Yang   +11 more
doaj   +1 more source

Smallpox [PDF]

The Boston Medical and Surgical Journal
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openaire   +4 more sources

Teaching a new mouse old tricks: Humanized mice as an infection model for Variola virus.

PLoS Pathogens, 2021
Smallpox, caused by the solely human pathogen Variola virus (VARV), was declared eradicated in 1980. While known VARV stocks are secure, smallpox remains a bioterrorist threat agent. Recent U.S. Food and Drug Administration approval of the first smallpox
Christina L Hutson, Ashley V Kondas, Jana M Ritter, Zachary Reed, Sharon Dietz Ostergaard, Clint N Morgan, Nadia Gallardo-Romero, Cassandra Tansey, Matthew R Mauldin, Johanna S Salzer, Christine M Hughes, Cynthia S Goldsmith, Darin Carroll, Victoria A Olson   +13 more
doaj   +1 more source

Improving the Care and Treatment of Monkeypox Patients in Low-Resource Settings: Applying Evidence from Contemporary Biomedical and Smallpox Biodefense Research

Viruses, 2017
Monkeypox is a smallpox-like illness that can be accompanied by a range of significant medical complications. To date there are no standard or optimized guidelines for the clinical management of monkeypox (MPX) patients, particularly in low-resource ...
M. Reynolds, A. McCollum, B. Nguete, Robert Shongo Lushima, B. Petersen   +4 more
semanticscholar   +1 more source

Micro/nanorobots for detecting and eliminating biological and chemical warfare agents

BMEMat, EarlyView.
Fuel‐powered and field‐driven micro/nanorobots provide a cutting‐edge platform to safeguard national security and defense. This review reports the latest research progress in micro/nanorobots in sensing and detoxifying biological and chemical warfare agents.
Song Li, Huaijuan Zhou, Di Shi, Zdeněk Sofer, Jinhua Li   +4 more
wiley   +1 more source

Populations Addressed in Vaccines Approved via the European Medicines Agency

Clinical Pharmacology &Therapeutics, EarlyView.
Therapeutic and prophylactic agents require robust evidence before patient use. Randomized controlled trials are essential for evaluating safety and efficacy but often exclude specific populations that are also targets for the intervention. This study assessed which populations are included in vaccine registration studies and/or addressed in label ...
Débora D. Gräf, Lukas Westphal, Jonathan Kimmelman, Christine E. Hallgreen   +3 more
wiley   +1 more source

Global perspectives on smallpox vaccine against monkeypox: a comprehensive meta-analysis and systematic review of effectiveness, protection, safety and cross-immunogenicity

Emerging Microbes and Infections
A large outbreak of monkeypox occurred in 2022, and most people lack immunity to orthopoxvirus. Smallpox vaccination is essential for preventing further smallpox outbreaks.
Hao Liu, Wenjing Wang, Yang Zhang, Fuchun Wang, Junyi Duan, Tao Huang, Xiaojie Huang, Tong Zhang   +7 more
doaj   +1 more source

Therapeutic Vaccines and Antibodies for Treatment of Orthopoxvirus Infections

Viruses, 2010
Despite the eradication of smallpox several decades ago, variola and monkeypox viruses still have the potential to become significant threats to public health.
Stuart N. Isaacs, Yuhong Xiao
doaj   +1 more source