Use of JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee on Immunization Practices — United States, 2022 [PDF]
MMWR. Morbidity and mortality weekly report, 2022 Certain laboratorians and health care personnel can be exposed to orthopoxviruses through occupational activities. Because orthopoxvirus infections resulting from occupational exposures can be serious, the Advisory Committee on Immunization Practices ...
A. Rao +10 more
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Evaluating the Immunogenicity and Safety of a Smallpox Vaccine to Monkeypox in Healthy Japanese Adults: A Single-Arm Study [PDF]
Life, 2023 Monkeypox (mpox) is an acute exanthematous disease caused by the monkeypox virus (MPXV). Since May 2022, patients with mpox have been reported worldwide, mainly in Europe and the Americas.
Noriko Tomita +13 more
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JMIR Research Protocols, 2023 BackgroundIn May 2022, a case of monkeypox (currently known as “mpox”) with no history of overseas travel was reported in the United Kingdom, followed by reports of infections reported in Europe, the United States, and other ...
Rina Yano +11 more
doaj +2 more sources
Short-Lived Neutralizing Antibody Responses to Monkeypox Virus in Smallpox Vaccine-Naive Persons after JYNNEOS Vaccination. [PDF]
Emerg Infect DisJYNNEOS, a third-generation smallpox vaccine, is integral to monkeypox virus (MPXV) control efforts, but the durability of this modified vaccinia Ankara–Bavarian Nordic (MVA-BN) vaccine’s effectiveness is undefined.
Phipps K +8 more
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BMC Microbiology, 2021 Background Anthrax and smallpox are high-risk infectious diseases, and considered as potential agents for bioterrorism. To develop an effective countermeasure for these diseases, we constructed a bivalent vaccine against both anthrax and smallpox by ...
Deok Bum Park +9 more
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A replication-competent smallpox vaccine LC16m8Δ-based COVID-19 vaccine [PDF]
Emerging Microbes and Infections, 2022 Viral vectors are a potent vaccine platform for inducing humoral and T-cell immune responses. Among the various viral vectors, replication-competent ones are less commonly used for coronavirus disease 2019 (COVID-19) vaccine development compared with ...
Akihiko Sakamoto +10 more
doaj +2 more sources
Immunogenicity and safety of three consecutive production lots of the non replicating smallpox vaccine MVA: A randomised, double blind, placebo controlled phase III trial [PDF]
PLoS ONE, 2018 BackgroundModified Vaccinia Ankara (MVA) is a live, viral vaccine under advanced development as a non-replicating smallpox vaccine. A randomised, double-blind, placebo-controlled phase III clinical trial was conducted to demonstrate the humoral ...
Chaplin, Paul +12 more
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Japanese journal of infectious diseases (Print), 2017 Monkeypox virus (MPXV) causes human monkeypox (human MPX), which is a similar disease to smallpox in humans. A previous study showed that a single vaccination of monkeys with LC16m8, a highly attenuated smallpox vaccine, protected them from MPX from 4-5 ...
Itoe Iizuka +10 more
semanticscholar +3 more sources
Interferon α/β Decoy Receptor Encoded by a Variant in the Dryvax Smallpox Vaccine Contributes to Virulence and Correlates with Severe Vaccine Side Effects [PDF]
mBio, 2022 Although providing long-lasting immunity, smallpox vaccination was associated with local and systemic reactions and rarely with severe complications, including progressive vaccinia and postvaccinia encephalitis. As the Dryvax smallpox vaccine consists of
Ruikang Liu +5 more
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Beyond the myths: Novel findings for old paradigms in the history of the smallpox vaccine. [PDF]
PLoS Pathog, 2018 1 Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, 2 Centre for Biological Threats and Special Pathogens 1 –Highly Pathogenic Viruses & German Consultant Laboratory for Poxviruses ...
Esparza J, Nitsche A, Damaso CR.
europepmc +2 more sources