Results 11 to 20 of about 635,087 (280)

Possible Mpox Protection from Smallpox Vaccine–Generated Antibodies among Older Adults [PDF]

Emerg Infect Dis, 2023
Smallpox vaccination may confer cross-protection to mpox. We evaluated vaccinia virus antibodies in 162 persons ≥50 years of age in Spain; 68.5% had detectable antibodies. Highest coverage (78%) was among persons 71–80 years of age.
Iván Sanz-Muñoz, Laura Sánchez-dePrada, Javier Sánchez-Martínez, Silvia Rojo-Rello, M. Domínguez-Gil, C. Hernán-García, V. Fernández-Espinilla, Raul Ortiz de Lejarazu-Leonardo, J. Castrodeza-Sanz, J. Eiros   +9 more
semanticscholar   +2 more sources

An open-label, non-randomized study investigating the safety and efficacy of smallpox vaccine, LC16, as post-exposure prophylaxis for mpox [PDF]

Hum Vaccin Immunother, 2023
Mpox is an acute exanthematous disease caused by the monkeypox virus. Since May 2022, it has spread as a community-acquired infection, mainly in Europe and the United States, and urgent measures to prevent this infection were also required in Japan.
N. Tomita, J. Terada-Hirashima, Y. Uemura, Yosuke Shimizu, H. Iwasaki, Rina Yano, Tetsuya Suzuki, S. Saito, N. Okumura, W. Sugiura, N. Ohmagari, M. Ujiie   +11 more
semanticscholar   +2 more sources

Safety and Efficacy of Post-Eradication Smallpox Vaccine as an Mpox Vaccine: A Systematic Review with Meta-Analysis [PDF]

Int J Environ Res Public Health, 2023
According to the World Health Organization, 83,339 laboratory-confirmed cases, including 72 deaths, of mpox (formerly known as monkeypox), have been reported from 110 locations globally as of 20 December 2022, making the disease a public health concern ...
Shelia Malone, A. Mitra, Nwanne Onumah, A. Brown, L. M. Jones, Da’Chirion Tresvant, C. Susan Brown, Austine U Onyia, Faith Iseguede   +8 more
semanticscholar   +2 more sources

Monkeypox in Patient Immunized with ACAM2000 Smallpox Vaccine During 2022 Outbreak [PDF]

Emerg Infect Dis, 2022
We report a case of monkeypox in the United States in a patient who had been vaccinated with ACAM2000 smallpox vaccine 8 years earlier. Despite his vaccination status, he still contracted disease.
M. Turner, J. Mandia, Case H Keltner, R. Haynes, Paul Faestel, L. Mease   +5 more
semanticscholar   +2 more sources

Mpox outbreak in the Netherlands, 2022: public health response, characteristics of the first 1,000 cases and protection of the first-generation smallpox vaccine [PDF]

Euro Surveill, 2023
In early May 2022, a global outbreak of mpox started among persons without travel history to regions known to be enzootic for monkeypox virus (MPXV). On 8 August 2022, the Netherlands reported its 1,000th mpox case, representing a cumulative incidence of
C. V. van Ewijk, F. Miura, G. V. van Rijckevorsel, H. D. de Vries, M. Welkers, O. E. van den Berg, I. Friesema, P. van den Berg, T. Dalhuisen, J. Wallinga, D. Brandwagt, B. V. van Cleef, H. Vennema, B. Voordouw, M. Koopmans, A. A. van der Eijk, C. Swaan, M. T. te Wierik, T. Leenstra, E. O. D. Op de Coul, E. Franz, B. V. van Benthem, D. Brandwagt, A. A. van der Eijk, H. Bos, C. van Bokhoven-Rombouts, L. Bovée, Chantal P. Rovers, B. V. van Cleef, A. V. van Dam, Rik van Dael, Jaap van Dissel, P. Ellerbroek, C. V. van Ewijk, E. Franz, C. Geurtsvankessel, J. V. D. van der Giessen, H. Götz, Josette Häger, S. van den Hof, E. Hoornenborg, Putri Hintaran, Jørgen de Jonge, R. Joosten, M. Koopmans, Kevin Kosterman, J. Lange, T. Leenstra, André J Meeske, L. Mollema, E. O. D. Op de Coul, Demi Reurings, G. V. van Rijckevorsel, H. Ruijs, C. Swaan, L. Smid, G. Sips, Sacha F de Stoppelaar, A. Vollaard, B. Voordouw, H. Vennema, H. D. de Vries, K. Veldkamp, K. Weijdema, Geert Westerhuis, M. T. te Wierik, M. Welkers, T. Waegemaekers, J. Wallinga, P. Zantkuijl   +69 more
semanticscholar   +2 more sources

Efficacy and Safety of the Smallpox Vaccine for Postexposure Prophylaxis in Monkeypox: Protocol for an Open-Labeled, Single-Armed Study

JMIR Research Protocols, 2023
BackgroundIn May 2022, a case of monkeypox (currently known as “mpox”) with no history of overseas travel was reported in the United Kingdom, followed by reports of infections reported in Europe, the United States, and other ...
Rina Yano, Junko Terada-Hirashima, Yukari Uemura, Noriko Tomita, Yosuke Shimizu, Haruka Iwasaki, Nobumasa Okumura, Tetsuya Suzuki, Sho Saito, Mugen Ujiie, Wataru Sugiura, Norio Ohmagari   +11 more
doaj   +2 more sources

Evaluating the Immunogenicity and Safety of a Smallpox Vaccine to Monkeypox in Healthy Japanese Adults: A Single-Arm Study [PDF]

Life, 2023
Monkeypox (mpox) is an acute exanthematous disease caused by the monkeypox virus (MPXV). Since May 2022, patients with mpox have been reported worldwide, mainly in Europe and the Americas.
Noriko Tomita, Eriko Morino, Junko Terada-Hirashima, Yukari Uemura, Yosuke Shimizu, Sho Saito, Tetsuya Suzuki, Nobumasa Okumura, Haruka Iwasaki, Hideki Ebihara, Masayuki Shimojima, Wataru Sugiura, Norio Ohmagari, Mugen Ujiie   +13 more
doaj   +2 more sources

A replication-competent smallpox vaccine LC16m8Δ-based COVID-19 vaccine [PDF]

Emerging Microbes and Infections, 2022
Viral vectors are a potent vaccine platform for inducing humoral and T-cell immune responses. Among the various viral vectors, replication-competent ones are less commonly used for coronavirus disease 2019 (COVID-19) vaccine development compared with ...
Akihiko Sakamoto, Hiroaki Osawa, Hinata Hashimoto, Tetsushi Mizuno, Ammar A. Hasyim, Yu-ichi Abe, Yuto Okahashi, Ryohei Ogawa, Mitsuhiro Iyori, Hisatoshi Shida, Shigeto Yoshida   +10 more
doaj   +2 more sources

Interferon α/β Decoy Receptor Encoded by a Variant in the Dryvax Smallpox Vaccine Contributes to Virulence and Correlates with Severe Vaccine Side Effects [PDF]

mBio, 2022
Although providing long-lasting immunity, smallpox vaccination was associated with local and systemic reactions and rarely with severe complications, including progressive vaccinia and postvaccinia encephalitis. As the Dryvax smallpox vaccine consists of
Ruikang Liu, Jeffrey L. Americo, Patricia L. Earl, Jack Villani, Catherine A. Cotter, Bernard Moss   +5 more
doaj   +2 more sources

Beyond the myths: Novel findings for old paradigms in the history of the smallpox vaccine [PDF]

PLoS Pathog, 2018
1 Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, 2 Centre for Biological Threats and Special Pathogens 1 –Highly Pathogenic Viruses & German Consultant Laboratory for Poxviruses ...
J. Esparza, A. Nitsche, C. Damaso
semanticscholar   +2 more sources