Results 11 to 20 of about 38,488 (237)

Evaluating the Immunogenicity and Safety of a Smallpox Vaccine to Monkeypox in Healthy Japanese Adults: A Single-Arm Study. [PDF]

Life (Basel), 2023
Monkeypox (mpox) is an acute exanthematous disease caused by the monkeypox virus (MPXV). Since May 2022, patients with mpox have been reported worldwide, mainly in Europe and the Americas.
Tomita N, Morino E, Terada-Hirashima J, Uemura Y, Shimizu Y, Saito S, Suzuki T, Okumura N, Iwasaki H, Ebihara H, Shimojima M, Sugiura W, Ohmagari N, Ujiie M.   +13 more
europepmc   +2 more sources

Global perspectives on smallpox vaccine against monkeypox: a comprehensive meta-analysis and systematic review of effectiveness, protection, safety and cross-immunogenicity. [PDF]

Emerg Microbes Infect
A large outbreak of monkeypox occurred in 2022, and most people lack immunity to orthopoxvirus. Smallpox vaccination is essential for preventing further smallpox outbreaks.
Liu H, Wang W, Zhang Y, Wang F, Duan J, Huang T, Huang X, Zhang T.   +7 more
europepmc   +2 more sources

Efficacy and Safety of the Smallpox Vaccine for Postexposure Prophylaxis in Monkeypox: Protocol for an Open-Labeled, Single-Armed Study.

JMIR Res Protoc, 2023
BackgroundIn May 2022, a case of monkeypox (currently known as “mpox”) with no history of overseas travel was reported in the United Kingdom, followed by reports of infections reported in Europe, the United States, and other ...
Yano R, Terada-Hirashima J, Uemura Y, Tomita N, Shimizu Y, Iwasaki H, Okumura N, Suzuki T, Saito S, Ujiie M, Sugiura W, Ohmagari N.   +11 more
europepmc   +2 more sources

A replication-competent smallpox vaccine LC16m8Δ-based COVID-19 vaccine. [PDF]

Emerg Microbes Infect, 2022
Viral vectors are a potent vaccine platform for inducing humoral and T-cell immune responses. Among the various viral vectors, replication-competent ones are less commonly used for coronavirus disease 2019 (COVID-19) vaccine development compared with ...
Sakamoto A, Osawa H, Hashimoto H, Mizuno T, Hasyim AA, Abe YI, Okahashi Y, Ogawa R, Iyori M, Shida H, Yoshida S.   +10 more
europepmc   +2 more sources

The origins and genomic diversity of American Civil War Era smallpox vaccine strains. [PDF]

Genome Biol, 2020
Vaccination has transformed public health, most notably including the eradication of smallpox. Despite its profound historical importance, little is known of the origins and diversity of the viruses used in smallpox vaccination.
Duggan AT, Klunk J, Porter AF, Dhody AN, Hicks R, Smith GL, Humphreys M, McCollum AM, Davidson WB, Wilkins K, Li Y, Burke A, Polasky H, Flanders L, Poinar D, Raphenya AR, Lau TTY, Alcock B, McArthur AG, Golding GB, Holmes EC, Poinar HN.   +21 more
europepmc   +2 more sources

Interferon α/β Decoy Receptor Encoded by a Variant in the Dryvax Smallpox Vaccine Contributes to Virulence and Correlates with Severe Vaccine Side Effects. [PDF]

mBio, 2022
Although providing long-lasting immunity, smallpox vaccination was associated with local and systemic reactions and rarely with severe complications, including progressive vaccinia and postvaccinia encephalitis. As the Dryvax smallpox vaccine consists of
Liu R, Americo JL, Earl PL, Villani J, Cotter CA, Moss B.   +5 more
europepmc   +2 more sources

Re-assembly of nineteenth-century smallpox vaccine genomes reveals the contemporaneous use of horsepox and horsepox-related viruses in the USA. [PDF]

Genome Biol, 2020
According to a recent article published in Genome Biology, Duggan and coworkers sequenced and partially assembled five genomes of smallpox vaccines from the nineteenth century.
Brinkmann A, Souza ARV, Esparza J, Nitsche A, Damaso CR.   +4 more
europepmc   +2 more sources

Short-Lived Neutralizing Antibody Responses to Monkeypox Virus in Smallpox Vaccine-Naive Persons after JYNNEOS Vaccination. [PDF]

Emerg Infect Dis
JYNNEOS, a third-generation smallpox vaccine, is integral to monkeypox virus (MPXV) control efforts, but the durability of this modified vaccinia Ankara–Bavarian Nordic (MVA-BN) vaccine’s effectiveness is undefined.
Phipps K, Yates J, Pettit J, Bialosuknia S, Hunt D, DuPuis AP, Payne A, Lee W, McDonough KA.   +8 more
europepmc   +2 more sources

ACAM2000™: The new smallpox vaccine for United States Strategic National Stockpile

Drug Design, Development and Therapy, 2010
Aysegul Nalca, Elizabeth E ZumbrunCenter for Aerobiological Sciences, US Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, MD, USAAbstract: Smallpox was eradicated more than 30 years ago, but heightened concerns over ...
Ayşegül Nalça, Elizabeth E. Zumbrun
openalex   +4 more sources

A History of Smallpox Vaccination in Modern China: Vaccine Techniques, Instruments, and Localization [PDF]

Uisahak, 2023
This paper examines how smallpox vaccination has been implemented in China from a technological perspective. It is an attempt not only to investigate the impact of technology and instruments on medical advances, but also to deepen the understanding of ...
Jeongeun JO
doaj   +1 more source