Results 161 to 170 of about 16,449 (234)

Heat shock protein 72 attenuates atherosclerosis in apolipoprotein E‐deficient mice

Journal of Diabetes Investigation, EarlyView.
Heat shock (HS) + mild electrical stimulation (MES)‐induced heat shock protein (HSP)72 expression prevents atherogenesis in HSP72+/+/ApoE−/− mice. HS + MES‐induced HSP72 expression reduces macrophage infiltration, oxidative stress, JNK activity, and MCP‐1 expression, and alters macrophage polarity from M1 to M2.
Rintaro Yoshizumi, Tatsuya Kondo, Takuro Watanabe, Nobukazu Miyakawa, Sayaka Kitano, Mary Ann Suico, Miki Sato, Masaji Sakaguchi, Motoyuki Igata, Takeshi Matsumura, Hirofumi Kai, Eiichi Araki, Naoto Kubota   +12 more
wiley   +1 more source

Condensin complexes: from chromatin organization to disease. [PDF]

Nucleus
Shu L, Zhang H.
europepmc   +1 more source

Cognitive and motor reserve in Parkinson's disease: Two sides of the same coin?

Journal of Neuropsychology, EarlyView.
Abstract Cognitive reserve (CR) and motor reserve (MR) are constructs that can explain why some people are more resilient than others to neurodegenerative diseases such as Parkinson's disease (PD). However, it is unclear whether these reserves exert domain‐specific or cross‐domain influences.
Isabella Anzuino, Sonia Di Tella, Alice Tondinelli, Clio Scopetani Testa, Martina Petracca, Maria Rita Lo Monaco, Anna Rita Bentivoglio, Maria Caterina Silveri   +7 more
wiley   +1 more source

Condensin IDC has a functional ATPase that is required for X-Chromosome dosage compensation in C. elegans. [PDF]

Genetics
Chawla B, Jatia S, Sloan D, Eduful J, Mendoza H, McClear CA, Tran J, Csankovszki G.   +7 more
europepmc   +1 more source

Reconstruction of native cellular microanatomy in a novel bioengineered full thickness human nasal mucosal construct

Journal of Anatomy, EarlyView.
Bioengineered tissue constructs are vital technologies employed in in vitro testing of both fundamental biological principles and industrial screening practices. Current approaches to modelling the nasal mucosa in vitro are not representative and are associated with limitations that impact their reliability and predictive value.
Steven Bradbury, Bethany Dickson, Nicola Curtis, David Bunton, Kirsty Goncalves, Stefan Przyborski   +5 more
wiley   +1 more source

Evaluating Large Language Model‐Assisted Emergency Triage: A Comparison of Acuity Assessments by GPT‐4 and Medical Experts

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To evaluate the accuracy of the Emergency Severity Index (ESI) assignments by GPT‐4, a large language model (LLM), compared to senior emergency department (ED) nurses and physicians. Method An observational study of 100 consecutive adult ED patients was conducted. ESI scores assigned by GPT‐4, triage nurses, and by a senior clinician. Both
Gal Ben Haim, Mor Saban, Yiftach Barash, David Cirulnik, Amit Shaham, Ben Zion Eisenman, Livnat Burshtein, Orly Mymon, Eyal Klang   +8 more
wiley   +1 more source

Structural and Signaling Mechanisms of Aortic Wall Failure in Heritable Thoracic Aortic Disease. [PDF]

Cells
Takeda N, Yagi H, Fujiwara T, Aono-Setoguchi H, Inuzuka R, Komuro I.   +5 more
europepmc   +1 more source

Flops and Missed Opportunities: The Differential Effect of Distinct Failure Types on Persistence With Underperforming Innovation Projects

Journal of Product Innovation Management, EarlyView.
ABSTRACT Academic Abstract Without recognizing how past failures bias subsequent choices, managers risk decisions that waste resources or prematurely abandon promising opportunities. This study draws on risk‐type preference‐shift theory and extends it with individual and organizational boundary conditions to examine how distinct failure experiences ...
Julian Nickel, Björn Hofmann, Monika C. Schuhmacher, Kumar R. Sarangee   +3 more
wiley   +1 more source

The Efficacy of Pharmacotherapy Intervention on Anthropometric Outcomes in Survivors of Childhood Brain Tumors: An Updated Systematic Review and Meta‐Analysis

Obesity Reviews, EarlyView.
ABSTRACT Introduction Many survivors of childhood brain tumors face long‐term adverse health outcomes like obesity. Uncertainties surround the effect of interventions to manage obesity‐related outcomes in survivors of childhood brain tumors. The goal of this updated systematic review and meta‐analysis was to provide the best estimate of the treatment ...
David Hart, Lawrence Mbuagbaw, Joseph Beyene, Marwa Akola, Sarah Burrow, M. Constantine Samaan, Lehana Thabane, Adam Fleming, Donna L. Johnston, Shahrad R. Rassekh, Laura Banfield, Russell J. de Souza   +11 more
wiley   +1 more source

A DNA tension-dependent tug-of-war between dimeric SMC motors governs loop extrusion directionality

Pradhan B, Pinto A, Tetiker D, Kanno T, Fisher GLM, Baaske MD, Cutts EE, Chatzicharlampous C, Schüler H, Deep A, Corbett KD, Aragon L, Virnau P, Björkegren C, Kim E.   +14 more
europepmc   +1 more source