Polycomb Repressive Complex 2 Regulates Lineage Fidelity during Embryonic Stem Cell Differentiation [PDF]
, 2014 Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation (H3K27me3), an epigenetic modification associated with gene repression.
Boyer, Laurie +3 more
core +3 more sources
Acta Physiologica, Volume 242, Issue 2, February 2026.ABSTRACT Aim Identifying interactors in sensorimotor processing and neurotransmission remains a current challenge for understanding neural information processing and brain function. Methods To evaluate the role of p11 in sensorimotor processing and excitatory synaptic neurotransmission, neuron‐specific lentivirus‐directed p11 silencing, small ...
Esther Vilches‐Herrando +7 more
wiley +1 more source
Beyond Inflammation: Why Understanding the Brain Matters in Inflammatory Arthritis
Arthritis Care &Research, Volume 78, Issue 1, Page 3-14, January 2026.Persistent pain remains a major challenge in inflammatory arthritis, even when joint inflammation is well controlled. Pain and associated symptoms such as fatigue cannot be explained by peripheral inflammation alone but reflect altered central pain processing. These changes may arise through “top‐down” mechanisms, reflecting pre‐existing dysfunction in
Eoin M. Kelleher +2 more
wiley +1 more source
Journal of the International AIDS Society, Volume 29, Issue 1, January 2026.Abstract Introduction Despite significant progress in HIV care globally, a persistent 30–40% of people present with advanced HIV disease with ≤200 CD4 cells/µl. The Visitect CD4 Advanced Disease platform is a point‐of‐care CD4 test being implemented in resource‐limited settings.
Elizabeth Nalintya +18 more
wiley +1 more source
Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis [PDF]
, 2017 Spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) are severe nervous system diseases characterized by the degeneration of lower motor neurons.
Sleigh, JN, Tosolini, AP
core +2 more sources
Structural basis of product recognition by Mycobacterium tuberculosis fatty acid synthase
Protein Science, Volume 35, Issue 1, January 2026.Abstract Microbial iterative fatty acid synthases (FAS) are versatile multienzymes under scrutiny for their potential as anti‐infectious targets and their biotechnological applications. They produce saturated fatty acids with defined chain length and release them as coenzyme A‐conjugates.
Elnaz Khalili Samani +4 more
wiley +1 more source
Antisense-based therapy for the treatment of spinal muscular atrophy [PDF]
, 2012 One of the greatest thrills a biomedical researcher may experience is seeing the product of many years of dedicated effort finally make its way to the patient.
Bennett, C. F. +3 more
core +1 more source
Increasing agrin function antagonizes muscle atrophy and motor impairment in spinal muscular atrophy [PDF]
, 2018 Spinal muscular atrophy (SMA) is a pediatric genetic disease, characterized by motor neuron (MN) death, leading to progressive muscle weakness, respiratory failure, and, in the most severe cases, to death. Abnormalities at the neuromuscular junction (NMJ)
Alessandro Vercelli +8 more
core +4 more sources
Use of RNA secondary structure for evolutionary relationships : investigating RNase P and RNase MRP : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University, New Zealand [PDF]
, 1998 Bioinformatics is applied here to examine whether RNA secondary structure data can reflect distant evolutionary relationships. This is important when there is little confidence in sequence data such as when looking at the evolution of RNase MRP (MRP ...
Collins, Lesley Joan
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Molecular bases of spinal muscular atrophy: the survival motor neuron gene [PDF]
, 2001 L'atròfia muscular espinal (AME) és una malaltia neuromuscular autosòmica recessiva caracteritzada per Ia degeneració i Ia pèrdua de Ies motoneurones de Ia banya anterior de Ia medul·la espinal.
Baiget Bastús, Montserrat +1 more
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