Results 121 to 130 of about 634,892 (192)

hnRNP R regulates mitochondrial movement and membrane potential in axons of motoneurons

Neurobiology of Disease
Axonal mitochondria defects are early events in the pathogenesis of motoneuron disorders such as spinal muscular atrophy and amyotrophic lateral sclerosis.
Sophia Dithmar, Abdolhossein Zare, Saeede Salehi, Michael Briese, Michael Sendtner   +4 more
doaj   +1 more source

Effect of Non-Coding RNA on Post-Transcriptional Gene Silencing of Alzheimer Disease [PDF]

, 2010
A large amount of hidden biological information is contained in the human genome, which is not expressed or revealed in the form of proteins; the usual end product form of gene expression.
Arun Mohan, Deepa Gopakumar, Krishnan Namboori, Premkumar P, Radhagayathri K.U., Ramachandran K.I., Varun Gopal, Vasavi C.S.   +7 more
core   +1 more source

Alternative splicing events driven by altered levels of GEMIN5 undergo translation

RNA Biology
GEMIN5 is a multifunctional protein involved in various aspects of RNA biology, including biogenesis of snRNPs and translation control. Reduced levels of GEMIN5 confer a differential translation to selective groups of mRNAs, and biallelic variants ...
Rosario Francisco-Velilla, Salvador Abellan, Juan Antonio Garcia-Martin, Juan Carlos Oliveros, Encarnacion Martinez-Salas   +4 more
doaj   +1 more source

Spliceosomal Sm core assembly: AlphaFold 3 predicted structure and phosphorylation-dependent regulation of the human 6S complex. [PDF]

Comput Struct Biotechnol J
Grimmler M, Reinhart M, Alers S, Peter C.   +3 more
europepmc   +1 more source

Novel Translational Concept: Axon-to-Muscle Exosomal Signaling as an Emerging Therapeutic Target in Spinal Muscular Atrophy. [PDF]

Biomedicines
Fajkić A, Belančić A, Lam YW, Rački V, Pilipović K, Janković T, Mežnarić S, Mršić-Pelčić J, Vitezić D.   +8 more
europepmc   +1 more source

SMN deficiency inhibits endochondral ossification via promoting TRAF6-induced ubiquitination degradation of YBX1 in spinal muscular atrophy. [PDF]

Bone Res
Zhou Z, Fan X, Xiang T, Suo Y, Shi X, Li Y, Hua Y, Sheng L, Zhou X.   +8 more
europepmc   +1 more source

The SMN complex: an assembly machine for RNPs.

Cold Spring Harbor Symposia on Quantitative Biology, 2006
D. Battle, M. Kasim, Jeongsik Yong, Francesco Lotti, C. Lau, J. Mouaikel, Zhenxi Zhang, K. Han, L. Wan, G. Dreyfuss   +9 more
semanticscholar   +1 more source

Arginine methylation-dependent METTL14-SMN interaction regulates RNA m⁶A homeostasis. [PDF]

EMBO Rep
Zhang Y, Shen L, Ren L, Wei J, Pham HQH, Tao X, Guo J, Wang Z, Shen B, Su R, He C, Yang Y.   +11 more
europepmc   +1 more source

Evolution of an RNP assembly system: A minimal SMN complex facilitates formation of UsnRNPs in Drosophila melanogaster

Proceedings of the National Academy of Sciences of the United States of America, 2008
M. Kroiss, J. Schultz, J. Wiesner, A. Chari, A. Sickmann, U. Fischer   +5 more
semanticscholar   +1 more source

SUMO2 promotes histone pre-mRNA processing by stabilizing histone locus body interactions and facilitating U7 snRNP assembly. [PDF]

Genes Dev
He S, Lyu P, Skinner MW, Desotell A, Foley B, McCaig CM, Wang W, Qian J, Tong L, Marzluff WF, Matunis MJ.   +10 more
europepmc   +1 more source