Results 91 to 100 of about 43,875 (295)
Inhibition of hedgehog pathway reveals the regulatory role of SMO in gastric cancer cells
Tumor Biology, 2017 Previous studies report aberrant activation of the hedgehog signaling pathway in the progression of various cancers. This study aimed to investigate the expressions of smoothened and downstream glioma-associated oncogene homology-1 in gastric cancer and ...
Zixin Yang +6 more
doaj +1 more source
Patched1 and Patched2 inhibit Smoothened non-cell autonomously
eLife, 2016 Smoothened (Smo) inhibition by Patched (Ptch) is central to Hedgehog (Hh) signaling. Ptch, a proton driven antiporter, is required for Smo inhibition via an unknown mechanism. Hh ligand binding to Ptch reverses this inhibition and activated Smo initiates
Brock Roberts +4 more
doaj +1 more source
Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models [PDF]
, 2021 Vikas Daggubati +10 more
openalex +1 more source
Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective A 2‐min digital clock‐drawing test (DCTclock) captures more granular features of the clock‐drawing process than the pencil‐and‐paper clock‐drawing test, revealing more subtle deficits at the preclinical stage of Alzheimer's disease (AD). A previous cross‐sectional study demonstrated that worse DCTclock performance was associated with
Jessie Fanglu Fu +16 more
wiley +1 more source
Mass spectral analysis and quantification of Secondary Ion Mass Spectrometry data
, 2014 This work highlights the possibility of improving the quantification aspect of Cs-complex ions in SIMS (Secondary Ion Mass Spectrometry), by combining the intensities of all possible Cs-complexes.
Balamurugan, A. K. +2 more
core +1 more source
Network Localization of Fatigue in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo +12 more
wiley +1 more source
Loss of the PTCH1 tumor suppressor defines a new subset of plexiform fibromyxoma. [PDF]
, 2019 BackgroundPlexiform fibromyxoma (PF) is a rare gastric tumor often confused with gastrointestinal stromal tumor. These so-called "benign" tumors often present with upper GI bleeding and gastric outlet obstruction.
Banerjee, Sudeep +9 more
core +1 more source
Invasion Percolation with Temperature and the Nature of SOC in Real Systems
, 1999 We show that the introduction of thermal noise in Invasion Percolation (IP) brings the system outside the critical point. This result suggests a possible definition of SOC systems as ordinary critical systems where the critical point correspond to set to
A. Gabrielli +21 more
core +1 more source
Structural insight into small molecule action on Frizzleds
Nature Communications, 2020 WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, tissue homeostasis and human disease but no small molecule drugs targeting FZD with distinct efficacy have emerged so far.
Paweł Kozielewicz +9 more
doaj +1 more source