Results 111 to 120 of about 49,437 (364)

Estimation, Analysis and Smoothing of Self-Similar Network Induced Delays in Feedback Control of Nuclear Reactors [PDF]

open access: yes, 2012
This paper analyzes a nuclear reactor power signal that suffers from network induced random delays in the shared data network while being fed-back to the Reactor Regulating System (RRS).
Das, Saptarshi   +5 more
core   +2 more sources

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

open access: yesMolecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo   +11 more
wiley   +1 more source

Controlled thinning and surface smoothening of silicon nanopillars [PDF]

open access: yesNanotechnology, 2009
A convenient method has been developed to thin electron beam fabricated Silicon nanopillars under controlled surface manipulation by transforming the surface of the pillars to an oxide shell layer followed by the growth of sacrificial ammonium silicon fluoride coating.
Kalem, S.   +6 more
openaire   +5 more sources

Experimental study on the tribo-chemical smoothening process between self-mated silicon carbide in a water-lubricated surface-contact reciprocating test

open access: yesFriction, 2018
Silicon carbide (SiC) can be tribo-chemically smoothened during a self-mated sliding procedure in the aqueous environment. As well reported in the point-contact tests, this smoothening process works well due to the abundant water as oxidant.
Le Jin   +4 more
doaj   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

open access: yesMolecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza   +5 more
wiley   +1 more source

Cilia-Mediated Hedgehog Signaling in Drosophila

open access: yesCell Reports, 2014
Cilia mediate Hedgehog (Hh) signaling in vertebrates and Hh deregulation results in several clinical manifestations, such as obesity, cognitive disabilities, developmental malformations, and various cancers.
Anujaianthi Kuzhandaivel   +3 more
doaj   +1 more source

Residue 6.43 defines receptor function in class F GPCRs

open access: yesNature Communications, 2021
The class Frizzled of G protein-coupled receptors (GPCRs) consist of ten Frizzled (FZD1-10) subtypes and Smoothened (SMO). Here the Schulte laboratory demonstrates that FZDs differ substantially from SMO in receptor activation-associated conformational ...
Ainoleena Turku   +4 more
doaj   +1 more source

Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K [PDF]

open access: yes, 2018
SMO (Smoothened), the central transducer of Hedgehog signaling, is coupled to heterotrimeric Gi proteins in many cell types, including cardiomyocytes.
Al-Owais, Moza   +6 more
core   +1 more source

Persistent currents in a Bose-Einstein condensate in the presence of disorder

open access: yes, 2007
We examine bosonic atoms that are confined in a toroidal, quasi-one-dimensional trap, subjected to a random potential. The resulting inhomogeneous atomic density is smoothened for sufficiently strong, repulsive interatomic interactions.
A.D. Jackson   +34 more
core   +1 more source

Pancreatic Islet-Autonomous Insulin and Smoothened-Mediated Signaling Modulate Identity Changes of Glucagon+ α-Cells

open access: yesNature Cell Biology, 2018
The mechanisms that restrict regeneration and maintain cell identity following injury are poorly characterized in higher vertebrates. Following β-cell loss, 1–2% of the glucagon-producing α-cells spontaneously engage in insulin production in mice.
V. Cigliola   +16 more
semanticscholar   +1 more source

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