Results 131 to 140 of about 18,652 (289)

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists [PDF]

, 2002
Maria Frank-Kamenetsky, Xiaoyan M. Zhang, Steve Bottega, Oivin Guicherit, Hynek Wichterle, Henryk Dudek, David Bumcrot, Frank Y. Wang, Simon Jones, Janine Shulok, Lee L. Rubin, Jeffery A. Porter   +11 more
openalex   +1 more source

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

Smoothened translates Hedgehog levels into distinct responses [PDF]

, 2003
Joan E. Hooper
openalex   +1 more source

An Integrated MATLAB Code for Homogenization‐Based Topology Optimization and Generating Functionally Graded Surface Lattices for Additive Manufacturing

Advanced Engineering Materials, EarlyView.
Unlocking structural efficiency, this work integrates homogenization‐based topology optimization with functionally graded triply periodic minimal surface lattices to create highly efficient, customizable lattice structures. Key achievements include the development of a versatile MATLAB framework, optimization of mechanical properties for additive ...
Mirhan Ozdemir, Ugur Simsek, Cemal Efe Gayir, Kadir Gunaydin, Orhan Gulcan   +4 more
wiley   +1 more source

Enhancing Corrosion Resistance and Mechanical Strength of 3D‐Printed Iron Polylactic Acid for Marine Applications via Laser Surface Texturing

Advanced Engineering Materials, EarlyView.
Laser surface texturing significantly improves the corrosion resistance and mechanical strength of 3D‐printed iron polylactic acid (Ir‐PLA) for marine applications. Optimal laser parameters reduce corrosion by 80% and enhance tensile strength by 25% and ductility by 15%.
Mohammad Rezayat, Mojtaba Karamimoghadam, Mohammadreza Lalegani Dezaki, Ali Zolfagharian, Giuseppe Casalino, Antonio Mateo, Mahdi Bodaghi   +6 more
wiley   +1 more source

Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2 [PDF]

, 2003
Stacey K. Ogden, Manuel Ascano, Melanie A. Stegman, Liza M. Suber, Joan E. Hooper, David J. Robbins   +5 more
openalex   +1 more source

An Examination of Aerosol Jet‐Printed Surface Roughness and its Impact on the Performance of High‐Frequency Electronics

Advanced Engineering Materials, EarlyView.
This study explores aerosol jet‐printed (AJP) surface roughness, its effects on the performance of microwave electronics, and its process contributors. First, an electromagnetic model is vetted for AJP's unique roughness signature. Simulations are built which show process‐induced roughness is as significant as conductor resistivity in driving microwave
Christopher Areias, Alkim Akyurtlu
wiley   +1 more source

Functional analysis in Drosophila indicates that the NBCCS/PTCH1 mutation G509V results in activation of smoothened through a dominant‐negative mechanism [PDF]

, 2004
Gary R. Hime, Hania Lada, Michael Fietz, Susan A Gillies, Abraham Passmore, Carol Wicking, Brandon J. Wainwright   +6 more
openalex   +1 more source

Statistical Distributions of Morphologically Classified Defects in Metal Additive Manufacturing with Implications for Fatigue Life Prediction

Advanced Engineering Materials, EarlyView.
Morphological features of three defect types in metal additive manufacturing (AM)—lack of fusion, keyhole, and gas‐entrapped pores—are statistically characterized using best‐fit distributions evaluated via coefficient‐of‐determination, Kolmogorov–Smirnov test, and quantile–quantile plots.
Ahmad Serjouei, Golnaz Shahtahmassebi
wiley   +1 more source

Phosphorylation of human glioma-associated oncogene 1 on Ser937 regulates Sonic Hedgehog signaling in medulloblastoma

Nature Communications
Aberrant activation of sonic hedgehog (SHH) signaling and its effector transcriptional factor GLI1 are essential for oncogenesis of SHH-dependent medulloblastoma (MBSHH) and basal cell carcinoma (BCC).
Ling-Hui Zeng, Chao Tang, Minli Yao, Qiangqiang He, Meiyu Qv, Qianlei Ren, Yana Xu, Tingyu Shen, Weizhong Gu, Chengyun Xu, Chaochun Zou, Xing Ji, Ximei Wu, Jirong Wang   +13 more
doaj   +1 more source