Results 31 to 40 of about 43,875 (295)

Developmental and Repairing Production of Myelin: The Role of Hedgehog Signaling

Frontiers in Cellular Neuroscience, 2018
Since the discovery of its role as a morphogen directing ventral patterning of the spinal cord, the secreted protein Sonic Hedgehog (Shh) has been implicated in a wide array of events contributing to the development, maintenance and repair of the central
Yousra Laouarem, Elisabeth Traiffort
doaj   +1 more source

Fog computing and convolutional neural network enabled prognosis for machining process optimization [PDF]

, 2019
Cloud enabled prognosis systems have been increasingly adopted by manufacturing industries. The effectiveness of the cloud systems is, however, crippled by the high latency of data transfer between shop floors and the cloud.To overcome the limitation ...
Li, Weidong, Liang, Yuchen, Lu, Xin, Wang, Sheng   +3 more
core   +1 more source

Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes

eLife, 2020
Dynamic trafficking of G protein-coupled receptors (GPCRs) out of cilia is mediated by the BBSome. In concert with its membrane recruitment factor, the small GTPase ARL6/BBS3, the BBSome ferries GPCRs across the transition zone, a diffusion barrier at ...
Shuang Yang, Kriti Bahl, Hui-Ting Chou, Jonathan Woodsmith, Ulrich Stelzl, Thomas Walz, Maxence V Nachury   +6 more
doaj   +1 more source

A novel site comes into sight

eLife, 2013
Oxysterols modulate the Hedgehog signalling pathway by binding a novel site on the membrane protein Smoothened, which may offer new options for the treatment of cancers linked to this pathway.
Yu Wang, Andrew P McMahon
doaj   +1 more source

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

eLife, 2019
Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al., 2016).
Maia Kinnebrew, Ellen J Iverson, Bhaven B Patel, Ganesh V Pusapati, Jennifer H Kong, Kristen A Johnson, Giovanni Luchetti, Kaitlyn M Eckert, Jeffrey G McDonald, Douglas F Covey, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi   +12 more
doaj   +1 more source

Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease [PDF]

, 2017
The Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder due to mutations in the NPC1 gene, encoding a transmembrane protein related to the Sonic hedgehog receptor, Patched, and involved in intracellular trafficking of ...
Canterini, Sonia, Dardis, Andrea, DE STEFANO, Maria Egle, Dragotto, Jessica, Erickson, Robert P., Fiorenza, Maria Teresa, Mangia, Franco, Zampieri, Stefania   +7 more
core   +1 more source

A Smo/Gli multitarget hedgehog pathway inhibitor impairs tumor growth [PDF]

, 2019
Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer strategy. A number of small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector glioma-associated oncogene 1 (Gli1)
Balducci, Silvia, BASILI, IRENE, Botta, Bruno, Bufalieri, Francesca, Caimano, Miriam, Di Marcotullio, Lucia, Ghirga, Francesca, Infante, Paola, LORICCHIO, ELENA, LOSPINOSO SEVERINI, LUDOVICA, Maroder, Marella, Moretti, Marta, Mori, Mattia, Quaglio, Deborah, ROMEO, ISABELLA   +14 more
core   +1 more source

Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity. [PDF]

PLoS ONE, 2014
A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the primary cilium (PC).
Marisa O Peluso, Veronica T Campbell, Joseph A Harari, Thomas T Tibbitts, Jennifer L Proctor, Nigel Whitebread, James M Conley, Kerry F White, Jeffery L Kutok, Margaret A Read, Karen McGovern, Kerrie L Faia   +11 more
doaj   +1 more source

The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability [PDF]

, 2016
USP21 is a centrosome-associated deubiquitylase (DUB) that has been implicated in the formation of primary cilia - crucial organelles for the regulation of the Hedgehog (Hh) signaling pathway in vertebrates. Here, we identify KCTD6 - a cullin-3 E3-ligase
Bertsoulaki, Erithelgi, Clague, Michael J., Cucchi, Danilo, DE SMAELE, Enrico, Heride, Claire, Rigden, Daniel J., Urbé, Sylvie   +6 more
core   +1 more source

Contact mechanics for randomly rough surfaces [PDF]

, 2006
When two solids are squeezed together they will in general not make atomic contact everywhere within the nominal (or apparent) contact area. This fact has huge practical implications and must be considered in many technological applications.
Archard, Arzt, B.N.J. Persson, Barquins, Bollinne, Borri-Brunetto, Borri-Brunetto, Bureau, Bureau, Bush, Bush, Buzza, Carbone, Carbone, Derjaguin, Derjaguin, Fuller, Gao, Gibson, Greenwood, Greenwood, Greenwood, Hertz, Hui, Hyun, Israelachvili, Johnson, Johnson, Jäckle, Laguarta, Luan, Mecke, Nayak, Ocko, Persson, Persson, Persson, Persson, Persson, Persson, Persson, Persson, Persson, Persson, Persson, Restagno, Seydel, Sherge, Tabor, Vorvolakos, Yang, Zhang   +51 more
core   +3 more sources