Results 41 to 50 of about 49,437 (364)
Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling
Nature Chemical Biology, 2020 Smoothened (SMO), a class Frizzled G protein-coupled receptor (class F GPCR), transduces the Hedgehog signal across the cell membrane. Sterols can bind to its extracellular cysteine-rich domain (CRD) and to several sites in the seven transmembrane ...
Xiaofeng Qi +4 more
semanticscholar +1 more source
Update on glasdegib in acute myeloid leukemia – broadening horizons of Hedgehog pathway inhibitors
Acta Pharmaceutica, 2022 Numerous new emerging therapies, including oral targeted chemotherapies, have recently entered the therapeutic arsenal against acute myeloid leukemia (AML). The significant shift toward the use of these novel therapeutics, administered either alone or in
Fersing Cyril, Mathias Fanny
doaj +1 more source
Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma
Case Reports in Dermatology, 2021 In basal cell carcinoma (BCC) tumorigenesis, interaction between Hedgehog (Hh) and Wnt/β-catenin (Wnt) signaling pathways has been investigated, but not completely elucidated.
Tomoaki Takada
doaj +1 more source
Structure du récepteur Smoothened [PDF]
médecine/sciences, 2013 The Smoothened (Smo) receptor is a major component involved in signal transduction of the Hedgehog (Hh) morphogens both during embryogenesis and in the adult. Smo antagonists represent a promi-sing alternative for the treatment of cancers linked to abnormal Hh signalling.
Martial Ruat +3 more
openalex +2 more sources
bioRxiv, 2020 The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and regeneration. Dysfunction of this cascade drives several cancers. To control expression of pathway target genes, the G protein-coupled receptor (GPCR) Smoothened (SMO ...
Corvin D. Arveseth +16 more
semanticscholar +1 more source
Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype [PDF]
, 2016 Hedgehog (Hh) inhibitors have emerged as valid tools in the treatment of a wide range of cancers. Indeed, aberrant activation of the Hh pathway occurring either by ligand-dependent or -independent mechanisms is a key driver in tumorigenesis.
Alfonsi, Romina +13 more
core +1 more source
Inhibition of Hedgehog Delays Liver Regeneration through Disrupting the Cell Cycle
Current Issues in Molecular Biology, 2022 Liver regeneration is a complicated biological process orchestrated by various liver resident cells. Hepatic cell proliferation and reconstruction of the hepatic architecture involve multiple signaling pathways. It has been reported that the Hh signal is
Jiawang Tao +7 more
doaj +1 more source
Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma [PDF]
, 2012 Basal cell carcinoma (BCC) of the skin is the most common type of cancer, and accounts for up to 40% of all cancers in the United States with a growing incidence rate in the last decades in all developed countries.
CUCCHI, DANILO +3 more
core +3 more sources
Glucocorticoids get Smoothened [PDF]
Science-Business eXchange, 2010 Duke researchers have identified multiple FDA-approved glucocorticoids that exhibit Smoothened agonist activity and can stimulate the proliferation of primary neuronal precursor cells. The proven safety records for these glucocorticoids could mean accelerated repurposing in various tissue repair and regenerative medicine applications.
openaire +2 more sources
Contributions of Noncanonical Smoothened Signaling During Embryonic Development
Journal of Developmental Biology, 2017 The Sonic Hedgehog (Shh) signaling pathway is active during embryonic development in metazoans, and provides instructional cues necessary for proper tissue patterning.
Tanushree Pandit, Stacey K. Ogden
doaj +1 more source