Results 41 to 50 of about 43,875 (295)

Simultaneous measurement of smoothened entry into and exit from the primary cilium. [PDF]

PLoS ONE, 2014
Ciliary accumulation of signaling proteins must result from a rate of ciliary entry that exceeds ciliary exit, but approaches for distinguishing ciliary entry vs. exit are lacking.
Jynho Kim, Elaine Y C Hsia, James Kim, Navdar Sever, Philip A Beachy, Xiaoyan Zheng   +5 more
doaj   +1 more source

Data analysis of molecular dynamics simulation trajectories of β-sitosterol, sonidegib and cholesterol in smoothened protein with the CHARMM36 force field

Data in Brief, 2020
Inactivation of smoothened protein (SMO) by the antagonists in SHH-driven cancer types is essential for inhibition of cancer progression. This article presents molecular dynamics (MD) trajectories of water solution of three protein-ligand complexes ...
Mohammad Tasyriq Che Omar
doaj   +1 more source

Disc measurement and nucleus calibration in a smoothened lumbar model increases the accuracy and efficiency of in-silico study

Journal of Orthopaedic Surgery and Research, 2021
Backgrounds Finite element analysis (FEA) is an important tool during the spinal biomechanical study. Irregular surfaces in FEA models directly reconstructed based on imaging data may increase the computational burden and decrease the computational ...
Jingchi Li, Chen Xu, Xiaoyu Zhang, Zhipeng Xi, Shenglu Sun, Ke Zhang, Xiaoyang Fang, Lin Xie, Yang Liu, Yueming Song   +9 more
doaj   +1 more source

Quenched central limit theorem for the stochastic heat equation in weak disorder

, 2018
We continue with the study of the mollified stochastic heat equation in $d\geq 3$ given by $d u_{\epsilon,t}=\frac 12\Delta u_{\epsilon,t}+ \beta \epsilon^{(d-2)/2} \,u_{\epsilon,t} \,d B_{\epsilon,t}$ with spatially smoothened cylindrical Wiener process
Chiranjib Mukherjee, E Bolthausen, F Comets, F Comets, F Comets, G Amir, J Magnen, L Bertini, M Hairer, Massimiliano Gubinelli, T Alberts   +10 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Structure and functional motifs of GCR1, the only plant protein with a GPCR fold? [PDF]

, 2013
Whether GPCRs exist in plants is a fundamental biological question. Interest in deorphanizing new G protein coupled receptors (GPCRs), arises because of their importance in signaling.
Abdalla, Nuradin Y, Bailey, Gregory R, Jordon, Sian R D, Reeves, Philip J, Reynolds, Christopher A, Taddese, Bruck, Upton, Graham J G   +6 more
core   +1 more source

Downregulation of Rab23 inhibits hepatocellular carcinoma by repressing SHH signaling pathway

Cancer Reports
Hepatocellular carcinoma (HCC) is the sixth most common malignant tumors and the third leading cause of cancer‐related death worldwide. As an oncogene, Rab23 has been shown to be significantly related to the growth and migration of hepatocellular ...
Si‐Jia Liu, Yu‐Wei Zang, Cui‐Jun Huang, Yun‐Jian Liu   +3 more
doaj   +1 more source

Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis

eLife, 2016
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in industrialized countries and is increasing in prevalence. The pathomechanisms, however, are poorly understood.
Madlen Matz-Soja, Christiane Rennert, Kristin Schönefeld, Susanne Aleithe, Jan Boettger, Wolfgang Schmidt-Heck, Thomas S Weiss, Amalya Hovhannisyan, Sebastian Zellmer, Nora Klöting, Angela Schulz, Jürgen Kratzsch, Reinhardt Guthke, Rolf Gebhardt   +13 more
doaj   +1 more source