Results 71 to 80 of about 49,437 (364)
Small molecule modulation of Smoothened activity [PDF]
Proceedings of the National Academy of Sciences, 2002 Smoothened (Smo), a distant relative of G protein-coupled receptors, mediates Hedgehog (Hh) signaling during embryonic development and can initiate or transmit ligand-independent pathway activation in tumorigenesis. Although the cellular mechanisms that regulate Smo function remain unclear, the direct inhibition of Smo by cyclopamine, a plant-derived ...
James K. Chen +4 more
openaire +2 more sources
Quenched central limit theorem for the stochastic heat equation in weak disorder
, 2018 We continue with the study of the mollified stochastic heat equation in $d\geq 3$ given by $d u_{\epsilon,t}=\frac 12\Delta u_{\epsilon,t}+ \beta \epsilon^{(d-2)/2} \,u_{\epsilon,t} \,d B_{\epsilon,t}$ with spatially smoothened cylindrical Wiener process
Chiranjib Mukherjee +10 more
core +1 more source
Geographic variation in walking activity in the red flour beetle Tribolium castaneum
Population Ecology, EarlyView.This study examined whether there is geographic variation in field populations, focusing on the moving activity in the red flour beetle Tribolium castaneum. Results showed significant differences in moving activity among field populations but no correlation with latitude or meteorological factors.
Kentarou Matsumura
wiley +1 more source
Contact mechanics for randomly rough surfaces [PDF]
, 2006 When two solids are squeezed together they will in general not make atomic contact everywhere within the nominal (or apparent) contact area. This fact has huge practical implications and must be considered in many technological applications.
Archard +51 more
core +3 more sources
Premelting-Induced Smoothening of the Ice-Vapor Interface [PDF]
Physical Review Letters, 2016 postprint plus supplemental material with details on simulation and ...
Benet, Jorge +3 more
openaire +6 more sources
eLife, 2016 Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in industrialized countries and is increasing in prevalence. The pathomechanisms, however, are poorly understood.
Madlen Matz-Soja +13 more
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
On the canonical connection for smooth envelopes
, 2013 A notion known as smooth envelope, or superposition closure, appears naturally in several approaches to generalized smooth manifolds which were proposed in the last decades. Such an operation is indispensable in order to perform differential calculus.
Moreno, Giovanni
core +2 more sources
Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease [PDF]
, 2017 The Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder due to mutations in the NPC1 gene, encoding a transmembrane protein related to the Sonic hedgehog receptor, Patched, and involved in intracellular trafficking of ...
Canterini, Sonia +7 more
core +1 more source
Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling
bioRxiv, 2019 In the absence of hedgehog ligand, patched-1 (Ptch1) localizes to cilia and prevents ciliary accumulation and activation of smoothened (Smo). Upon ligand binding, Ptch1 is removed from cilia, Smo is derepressed and accumulates in cilia where it activates
Paurav B. Desai +3 more
semanticscholar +1 more source