Results 201 to 210 of about 12,144 (240)

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss. [PDF]

Adv Sci (Weinh)
Mao H, Li X, Liao Y, Liu L, Gao X, Lin H, Ni W, Li H, Chen Y, Li W.   +9 more
europepmc   +1 more source

In vitro differentiation of the hypothalamic KNDy neuron, a master regulator for reproduction, from mouse embryonic stem cells. [PDF]

Reprod Biol Endocrinol
Miyake N, Suga H, Osuka S, Seki T, Sonehara R, Muraoka A, Nakamura T, Bayasula, Miwata T, Soen M, Sakakibara M, Go S, Hasegawa S, Inoue N, Uenoyama Y, Tsukamura H, Arima H, Kajiyama H.   +17 more
europepmc   +1 more source

Advancing Medulloblastoma Treatment: Molecular Mechanisms, Drug Repurposing, and Precision Therapies. [PDF]

Mol Diagn Ther
Abdel-Rasol MA, El-Sayed WM.
europepmc   +1 more source

Resistance to SMO Inhibitors in Advanced Basal Cell Carcinoma: A Case Highlighting the Role of Molecular Tumor Profiling. [PDF]

Int J Mol Sci
Papaccio F, Marrapodi R, Eibenschutz L, D'Arino A, Caputo S, Marini A, Scano S, Presaghi A, Cota C, Melucci E, Scalera S, Migliano E, Maugeri-Saccà M, Frascione P, Bellei B.   +14 more
europepmc   +1 more source

AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting_suppl1

ALTEX
openaire   +1 more source

Author response: Multiple modes of cholesterol translocation in the human Smoothened receptor

Prateek Bansal, Maia Kinnebrew, Rajat Rohatgi, Diwakar Shukla   +3 more
openaire   +1 more source

Regulation of Smoothened by Drosophila G-protein-coupled receptor kinases

Developmental Biology, 2010
The Hedgehog (Hh) signaling pathway plays a conserved and essential role in regulating development and homeostasis of numerous tissues. Cytoplasmic signaling is initiated by Smoothened (Smo), a G-protein-coupled receptor (GPCR) family member, whose levels and activity are regulated by the Hh receptor Patched (Ptc). In response to Hh binding to Ptc, Ptc-
David R Hipfner
exaly   +3 more sources

The Development of a High-Content Screening Binding Assay for the Smoothened Receptor [PDF]

Journal of Biomolecular Screening, 2012
In this study, the development of an image-based high-content screening (HCS) binding assay for the seven-transmembrane (7TM) receptor Smoothened (Smo) is described. Using BacMam-based gene delivery of Smo, BODIPY-cyclopamine as a fluorescent probe, and a confocal imaging system, a robust 384-well assay that could be used for high-throughput compound ...
William J Zuercher, Keith R Hornberger, Robert S Ames   +2 more
exaly   +3 more sources

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Structural optimization on a virtual screening hit of smoothened receptor

European Journal of Medicinal Chemistry, 2019
The Hedgehog (Hh) pathway plays a critical role during embryonic development by controlling cell patterning, growth and migration. In adults, the function of Hh pathway is curtailed to tissue repair and maintenance. Aberrant reactivation of Hh signaling has been linked to tumorigenesis in various cancers, such as basal cell carcinoma (BCC) and ...
Chaonan Zheng, Haikuo Ma, Sheng Tian
exaly   +3 more sources

Stability study of the human G-protein coupled receptor, Smoothened

Biochimica Et Biophysica Acta - Biomembranes, 2010
Smoothened is a member of the G-protein coupled receptor (GPCR) family responsible for the transduction of the Hedgehog signal to the intracellular effectors of the Hedgehog signaling pathway. Aberrant regulation of this receptor is implicated in many cancers but also in neurodegenerative disorders.
Olivier Joubert, Ange Polidori, Bernard Pucci   +2 more
exaly   +5 more sources