Results 221 to 230 of about 12,144 (240)

Attenuation of early liver fibrosis by pharmacological inhibition of smoothened receptor signaling

Journal of Drug Targeting, 2012
Hedgehog (Hh) signaling is involved in the pathogenesis of liver fibrosis. It has been previously shown that Hh-inhibitor cyclopamine (CYA) can reduce liver fibrosis in rats. However, CYA is not stable in vivo, which limits its clinical application.
Akshay, Pratap, Saurabh, Singh, Vaibhav, Mundra, Ningning, Yang, Ravikiran, Panakanti, James D, Eason, Ram I, Mahato   +6 more
openaire   +2 more sources

Computer-aided design of arylphthalazines as potential smoothened receptor antagonists

Doklady Chemistry, 2012
The goal is to propose a model of activity-structure relations for antagonists. A comparative analysis of activity charts for molecular field topology analysis and comparative molecular similarity indices analysis demonstrates a good coherence. A virtual screening method is used for the synthesis of the new antagonists.
Radchenko, E. V., Koshelev, S. O., Tsareva, D. A., Voronkov, A. E., Palyulin, V. A., Zefirov, N. S.   +5 more
openaire   +2 more sources

Colocalization Strategy Unveils an Underside Binding Site in the Transmembrane Domain of Smoothened Receptor

Journal of Medicinal Chemistry, 2019
We unveiled an underside binding site on smoothened receptor (SMO) by a colocalization strategy using two structurally complementary photoaffinity probes derived from a known ligand Allo-1. Docking study and structural dissection identified key interactions within the site, including hydrogen bonding, π-π interactions, and hydrophobic interactions ...
Fang Zhou, Kang Ding, Yiqing Zhou, Yang Liu, Xiaoyan Liu, Fei Zhao, Yiran Wu, Xianjun Zhang, Qiwen Tan, Fei Xu, Wenfu Tan, Youli Xiao, Suwen Zhao, Houchao Tao   +13 more
openaire   +2 more sources

Three-Dimensional Structure of the Smoothened Receptor: Implications for Drug Discovery

2014
The recently described high resolution three-dimensional structures of the transmembrane and the extracellular domains of the human Smoothened (Smo) receptor higlight both conserved and unique structural features of this G protein-coupled receptor.
Didier Rognan, Isabelle Mus-Veteau
openaire   +1 more source

Diphenolic Acid in Plastics Activates Smoothened Receptor

The FASEB Journal, 2016
Kirti Kandhwal, Irina Kufareva, Milind Parle, Ruben Abagyan   +3 more
openaire   +1 more source

Resistance to Hedgehog inhibitor through Smoothened receptor mutation in basal cell carcinoma.

2013
The inappropriate activation of Hedgehog (Hh) pathway is involved in the pathogenesis of skin basal cell carcinoma (BCC). Loss of function of the transmembrane receptor Patched (PTCH1), or gain of function of the Smoothened (SMO), Sonic Hh (SHH), and GLI family transcription factors can be ligand-independent oncogenic drivers of this disease.
Bossi, Paolo, Perrone, Federica, Cortellazzi, Barbara, Licitra, Lisa, Dal Col, Valentina, LAURINI, ERIK, FERMEGLIA, MAURIZIO, PRICL, SABRINA   +7 more
openaire   +2 more sources

Fully activated structure of the sterol-bound Smoothened GPCR-Gi protein complex

Proceedings of the National Academy of Sciences of the United States of America, 2023
Amy-Doan P Võ, Soo-Kyung Kim, Moon Young Yang   +2 more
exaly  

Sonidegib phosphate: Smoothened (SMO) receptor antagonist oncolytic

Drugs of the Future, 2014
null Salati, M., null Stathis, A.
openaire   +1 more source

Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened

Structure, 2019
George Hedger, Heidi Koldsø, Matthieu Chavent   +2 more
exaly  

Molecular basis of drug resistance in smoothened receptor: An in silico study of protein resistivity and specificity

Proteins: Structure, Function and Bioinformatics, 2020
Noopur Sinha, Saikat Chowdhury, Ram Rup Sarkar   +2 more
exaly