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Three-Dimensional Structure of the Smoothened Receptor: Implications for Drug Discovery
2014The recently described high resolution three-dimensional structures of the transmembrane and the extracellular domains of the human Smoothened (Smo) receptor higlight both conserved and unique structural features of this G protein-coupled receptor.
Didier Rognan, Isabelle Mus-Veteau
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Diphenolic Acid in Plastics Activates Smoothened Receptor
The FASEB Journal, 2016Kirti Kandhwal +3 more
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Sonidegib phosphate: Smoothened (SMO) receptor antagonist oncolytic
Drugs of the Future, 2014null Salati, M., null Stathis, A.
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Fully activated structure of the sterol-bound Smoothened GPCR-Gi protein complex
Proceedings of the National Academy of Sciences of the United States of America, 2023Soo-Kyung Kim +2 more
exaly
Resistance to Hedgehog inhibitor through Smoothened receptor mutation in basal cell carcinoma.
2013The inappropriate activation of Hedgehog (Hh) pathway is involved in the pathogenesis of skin basal cell carcinoma (BCC). Loss of function of the transmembrane receptor Patched (PTCH1), or gain of function of the Smoothened (SMO), Sonic Hh (SHH), and GLI family transcription factors can be ligand-independent oncogenic drivers of this disease.
Bossi, Paolo +7 more
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