Results 211 to 220 of about 12,144 (240)

Sonic hedgehog signaling by the Patched–Smoothened receptor complex [PDF]

Current Biology, 1999
The Hedgehog (Hh) family of secreted proteins is involved in a number of developmental processes as well as in cancer. Genetic and biochemical data suggest that the Sonic hedgehog (Shh) receptor is composed of at least two proteins: the tumor suppressor protein Patched (Ptc) and the seven-transmembrane protein Smoothened (Smo).Using a biochemical assay
Arnon Rosenthal, Frédéric J De Sauvage   +1 more
exaly   +3 more sources

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Inhibition of smoothened receptor by vismodegib leads to micrognathia during embryogenesis

Differentiation, 2022
The mandible is an important part of the craniofacial skeleton. Mandibular development is complex and involves multiple signaling pathways. These signaling pathways participate in a complex regulatory mechanism to regulate mandibular growth. The function of hedgehog signaling has previously been shown to be crucial for mandibular arch development.
Yan Guo, Di Wu, QingJiang Xu, Weihui Chen   +3 more
openaire   +2 more sources

Effect of the sonic hedgehog receptor smoothened on the survival and function of dopaminergic neurons [PDF]

Experimental Neurology, 2016
To determine the influence of the sonic hedgehog (shh) pathway and its receptor smoothened (smo), on the survival and functionality of dopaminergic (DA) neurons.During early development, shh induces the differentiation of DA neurons. However, it is unknown whether shh signaling is required in the maturation or maintenance of DA neurons during later ...
Jonathan Pace, Tao Lv, Barry J Hoffer
exaly   +3 more sources

Evidence for Allosteric Interactions of Antagonist Binding to the Smoothened Receptor

The Journal of Pharmacology and Experimental Therapeutics, 2009
The Smoothened receptor (Smo) mediates hedgehog (Hh) signaling critical for development, cell growth, and migration, as well as stem cell maintenance. Aberrant Hh signaling pathway activation has been implicated in a variety of cancers, and small-molecule antagonists of Smo have entered human clinical trials for the treatment of cancer. Here, we report
Cynthia M, Rominger, Wei-Lin Tiger, Bee, Robert A, Copeland, Elizabeth A, Davenport, Aidan, Gilmartin, Richard, Gontarek, Keith R, Hornberger, Lorena A, Kallal, Zhihong, Lai, Kenneth, Lawrie, Quinn, Lu, Lynette, McMillan, Maggie, Truong, Peter J, Tummino, Brandon, Turunen, Matthew, Will, William J, Zuercher, David H, Rominger   +17 more
openaire   +2 more sources

Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling

Trends in Cell Biology, 2010
The Hedgehog signalling pathway controls numerous developmental processes. In response to Hedgehog, Smoothened (Smo), a seven-pass transmembrane protein, orchestrates pathway signalling and controls transcription factor activation. In the absence of Hedgehog, the receptor Patched indirectly inhibits Smo in a catalytic manner. Many questions surrounding
Katie L Ayers, Pascal P Therond
exaly   +4 more sources

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

Nature, 1996
Members of the Hedgehog family of secreted proteins control a number of important inductive interactions in the development of both vertebrates and Drosophila, but little is known about the ways in which their signalling activities are transduced. In Drosophila, hedgehog is one of the segment-polarity genes, mutations of which disrupt the pattern and ...
Marcel Van den Heuvel, Philip W Ingham, M Van den Heuvel   +2 more
exaly   +3 more sources

The structure-based traceless specific fluorescence labeling of the smoothened receptor

Organic & Biomolecular Chemistry, 2019
Inspired by recent progress in structural studies of the smoothened receptor (SMO), a group of affinity probes were developed to specifically light up SMO by grafting a small fluorescent group at the specific residue K395.
Dongxiang Xue, Lintao Ye, Jun Zheng, Yiran Wu, Xianjun Zhang, Yueming Xu, Tao Li, Raymond C. Stevens, Fei Xu, Min Zhuang, Suwen Zhao, Fei Zhao, Houchao Tao   +12 more
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Smoothened receptor as a novel target for remyelination therapies

2021
Multiple Sclerosis (MS) is an autoimmune demyelinating disease of unknown aetiology, causing neurodegeneration in the Central Nervous System (CNS). Although the spontaneous capacity of myelin to regenerate can restore neuronal function, during MS progression, the instauration of an inflammatory microenvironment limits oligodendrocyte precursor cells ...
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[Structure of the Smoothened receptor].

Medecine sciences : M/S, 2014
The Smoothened (Smo) receptor is a major component involved in signal transduction of the Hedgehog (Hh) morphogens both during embryogenesis and in the adult. Smo antagonists represent a promi-sing alternative for the treatment of cancers linked to abnormal Hh signalling.
Martial, Ruat, Lucile, Hoch, Hélène, Faure, Didier, Rognan   +3 more
openaire   +1 more source

Pharmacological and structural studies on the hedgehog pathway receptor smoothened

2023
The Frizzled-class G protein-coupled receptor Smoothened (SMO) is an essential component of the Hedgehog (HH) signalling pathway, which is of paramount importance to developmental processes of bilaterians. Dysregulation of HH signalling has been implicated in multiple pathophysiological processes in adult organisms, such as cancer development.
openaire   +1 more source