Results 121 to 130 of about 1,881 (140)

Dual-functional biomimetic periosteum incorporating engineered small extracellular vesicles for treating critical bone defect with soft tissue fenestration via TGF-beta1/SMAD pathway. [PDF]

Mater Today Bio
Zhang Z, Shen J, Xu R, Yang Y, Yu X, Yu D, Deng F.   +6 more
europepmc   +1 more source

Engineering human bone marrow-derived mesenchymal stromal cell aggregates for enhanced extracellular vesicle secretion in a vertical-wheel bioreactor. [PDF]

Front Bioeng Biotechnol
Berry D, Boirie B, Singh M, Sun L, Jung S, Li Y, Zeng C.   +6 more
europepmc   +1 more source

SMPD4-mediated sphingolipid metabolism regulates brain and primary cilia development.

Development
Inskeep KA, Crase B, Dayarathna T, Stottmann RW.   +3 more
europepmc   +1 more source

Blockade of neutral sphingomyelinase 2 exerts antitumor effect on metastatic castration resistant prostate cancer cells and promotes tumor regression when combined with Enzalutamide. [PDF]

Am J Cancer Res
Shams SG, Dawud D, Michalak K, Makhlouf MM, Moustafa A, Jazwinski SM, Kang L, Zerfaoui M, El Sayed KA, Abd Elmageed ZY.   +9 more
europepmc   +1 more source

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Inducible transient expression of Smpd3 prevents early lethality in fro/fro mice

Genesis, 2014
SummarySphingomyelin phosphodiesterase 3 (SMPD3) is a pleiotropic lipid metabolizing enzyme involved in multiple physiological processes. A deletion mutation in the murine Smpd3 gene called fragilitas ossium (fro) leads to severe skeletal abnormalities in the developing fro/fro embryos.
Monzur Murshed
exaly   +4 more sources

Smpd3 regulates odontoblast differentiation through the Shh-Gli1 pathway.

Bone
Teeth, like other ectodermal organs such as hair, skin, and sweat glands, are complex structures. Specifically, teeth are composed of four principal tissues: enamel, dentin, cementum, and pulp.
C. Chu, Jiaohong Wang, Chi Zhang, Guoqing Li, Lin Wang   +4 more
semanticscholar   +3 more sources

A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd3) results in osteogenesis and dentinogenesis imperfecta in the mouse

Nature Genetics, 2005
The mouse mutation fragilitas ossium (fro) leads to a syndrome of severe osteogenesis and dentinogenesis imperfecta with no detectable collagen defect. Positional cloning of the locus identified a deletion in the gene encoding neutral sphingomyelin phosphodiesterase 3 (Smpd3) that led to complete loss of enzymatic activity.
Nathalie Auge, Anne Nègre-Salvayre, Robert Salvayre   +2 more
exaly   +4 more sources

SMPD3 Inhibition Contributes to Nicotinamide-Ameliorated Hepatic Steatosis in Chronic Alcohol-Fed Mice.

Journal of Agricultural and Food Chemistry
Alcohol-associated liver disease (ALD) is characterized by the reduction of hepatic nicotinamide adenine dinucleotide (NAD+), which exacerbates hepatic steatosis. The present study was conducted to investigate the protective role of nicotinamide (NAM), a
Qinchao Ding, Wenjing Cao, Xinxuan Ge, Feiwei Cao, Qing Song, Yue Jin, Tianchi Sun, Haoyi Fang, Jiaxin Li, Songtao Li   +9 more
semanticscholar   +3 more sources

Abstract C20: Smpd3 augments chemotherapy and thwarts PDA progression

Cancer Research, 2019
Deregulated sphingolipid metabolism alters pancreatic cancer progression; for that reason, bioactive lipid signaling molecules such as ceramide show promise as both biomarkers for disease progression and novel therapeutic targets.
A. M. Hendley, Atsushi Urano, Natanya R. Kerper, Phat Duong, Peter Bailey, D. Chang, A. Biankin, D. Dawson, Grace E. Kim, R. Raffai, Matthias Hebrok   +10 more
semanticscholar   +2 more sources

Role of SMPD3 during Bone Fracture Healing and Regulation of Its Expression [PDF]

Molecular and Cellular Biology, 2019
Sphingomyelin phosphodiesterase 3 (SMPD3), a lipid-metabolizing enzyme present in bone and cartilage, has important roles in the developing skeleton. We previously showed that SMPD3 deficiency results in delayed extracellular matrix (ECM) mineralization and severe skeletal deformities in an inducible knockout mouse model, Smpd3flox/flox ; Osx-Cre mice,
Pierre Moffatt, Monzur Murshed
exaly   +3 more sources