Results 61 to 70 of about 1,974 (156)
SMYD3–PARP16 axis accelerates unfolded protein response and mediates neointima formation
Acta Pharmaceutica Sinica B, 2021 Neointimal hyperplasia after vascular injury is a representative complication of restenosis. Endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) is involved in the pathogenesis of vascular intimal hyperplasia.
Fen Long +7 more
doaj +1 more source
Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics
The FEBS Journal, Volume 293, Issue 5, Page 1433-1458, March 2026.NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang +5 more
wiley +1 more source
Taxonomy of Chemical Bondings: Opportunities and Challenges
Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.The recent focus on supramolecular and nanosized systems produced a major increase in the types of observed noncovalent interactions and in the diversity of terms used to designate them. A hierarchical categorization (taxonomy) of terms used to designate electrophile···nucleophile interactions is proposed here.
Andrea Pizzi +5 more
wiley +2 more sources
Is MYND Domain-Mediated Assembly of SMYD3 Complexes Involved in Calcium Dependent Signaling?
Frontiers in Molecular Biosciences, 2019 Macromolecular complexes are essential to intracellular signal transduction by creating signaling niches and enabling a chain of reactions that transmit external signals into various cellular responses.
Yingxue Zhang, Chunying Li, Zhe Yang
doaj +1 more source
The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu +8 more
wiley +1 more source
Host factor SMYD3 is recruited by Ebola virus nucleoprotein to facilitate viral mRNA transcription
Emerging Microbes and Infections, 2019 The polymerase complex of Ebola virus (EBOV) is the functional unit for transcription and replication of viral genome. Nucleoprotein (NP) is a multifunctional protein with high RNA binding affinity and recruits other viral proteins to form functional ...
Jingliang Chen +8 more
doaj +1 more source
Genetics Research , Volume 2026, Issue 1, 2026.Background ANCA‐associated vasculitis (AAV) includes microscopic polyarteritis (MPA), granulomatosis with polyangiitis (GPA), and eosinophilic granulomatosis with polyangiitis (EGPA). Studies have revealed that infection‐related immune responses could trigger vasculitis.
Naidan Zhang +4 more
wiley +1 more source
Requirement of Histone Methyltransferase SMYD3 for Estrogen Receptor-mediated Transcription [PDF]
Journal of Biological Chemistry, 2009 SMYD3 is a SET domain-containing protein with histone methyltransferase activity on histone H3-K4. Recent studies showed that SMYD3 is frequently overexpressed in different types of cancer cells, but how SMYD3 regulates the development and progression of these malignancies remains unknown.
Hyunjung, Kim +5 more
openaire +2 more sources
Exosome‐Related Gene Signature Predicts Prognosis and Immunotherapy in Gastric Cancer
International Journal of Genomics, Volume 2026, Issue 1, 2026.Exosomes play a crucial role in tumor progression. However, reliable exosome‐related biomarkers for predicting prognosis in gastric cancer (GC) remain scarce. This study is aimed at developing an exosome‐related gene risk signature (ERGRS) to predict the survival outcomes and immunotherapy sensitivity in GC patients.
Qunru Jiao +5 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue 12, Page 3486-3498, December 2025.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source