Results 61 to 70 of about 2,026 (156)
Requirement of Histone Methyltransferase SMYD3 for Estrogen Receptor-mediated Transcription [PDF]
Journal of Biological Chemistry, 2009 SMYD3 is a SET domain-containing protein with histone methyltransferase activity on histone H3-K4. Recent studies showed that SMYD3 is frequently overexpressed in different types of cancer cells, but how SMYD3 regulates the development and progression of these malignancies remains unknown.
Hyunjung, Kim +5 more
openaire +2 more sources
Marine Drugs, 2020 Chitooligosaccharides (COS) have a variety of biological activities due to their positively charged amino groups. Studies have shown that COS have antidiabetic effects, but their molecular mechanism has not been fully elucidated.
Qiutong Wang +7 more
doaj +1 more source
RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang +6 more
wiley +1 more source
Is MYND Domain-Mediated Assembly of SMYD3 Complexes Involved in Calcium Dependent Signaling?
Frontiers in Molecular Biosciences, 2019 Macromolecular complexes are essential to intracellular signal transduction by creating signaling niches and enabling a chain of reactions that transmit external signals into various cellular responses.
Yingxue Zhang, Chunying Li, Zhe Yang
doaj +1 more source
Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics
The FEBS Journal, Volume 293, Issue 5, Page 1433-1458, March 2026.NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang +5 more
wiley +1 more source
Taxonomy of Chemical Bondings: Opportunities and Challenges
Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.The recent focus on supramolecular and nanosized systems produced a major increase in the types of observed noncovalent interactions and in the diversity of terms used to designate them. A hierarchical categorization (taxonomy) of terms used to designate electrophile···nucleophile interactions is proposed here.
Andrea Pizzi +5 more
wiley +2 more sources
Host factor SMYD3 is recruited by Ebola virus nucleoprotein to facilitate viral mRNA transcription
Emerging Microbes and Infections, 2019 The polymerase complex of Ebola virus (EBOV) is the functional unit for transcription and replication of viral genome. Nucleoprotein (NP) is a multifunctional protein with high RNA binding affinity and recruits other viral proteins to form functional ...
Jingliang Chen +8 more
doaj +1 more source
The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu +8 more
wiley +1 more source
The SMYD3 methyltransferase promotes myogenesis by activating the myogenin regulatory network [PDF]
Scientific Reports, 2019 ABSTRACT The coordinated expression of myogenic regulatory factors, including MyoD and myogenin, orchestrates the steps of skeletal muscle development, from myoblast proliferation and cell-cycle exit, to myoblast fusion and myotubes maturation.
Codato, Roberta +7 more
openaire +2 more sources
Exosome‐Related Gene Signature Predicts Prognosis and Immunotherapy in Gastric Cancer
International Journal of Genomics, Volume 2026, Issue 1, 2026.Exosomes play a crucial role in tumor progression. However, reliable exosome‐related biomarkers for predicting prognosis in gastric cancer (GC) remain scarce. This study is aimed at developing an exosome‐related gene risk signature (ERGRS) to predict the survival outcomes and immunotherapy sensitivity in GC patients.
Qunru Jiao +5 more
wiley +1 more source