Results 81 to 90 of about 2,026 (156)

Effect of SMYD3 on Biological Behavior and H3K4 Methylation in Bladder Cancer [Retraction]

Cancer Management and Research, 2023
Wu X, Xu Q, Chen P, et al. Cancer Manag Res. 2019;11:8125–8133. We, the Editor and Publisher of Cancer Management and Therapy are retracting the published article.
Wu X, Xu Q, Chen P, Yu C, Ye L, Huang C, Li T   +6 more
doaj  

A Novel lncRNA IHS Promotes Tumor Proliferation and Metastasis in HCC by Regulating the ERK- and AKT/GSK-3β-Signaling Pathways

Molecular Therapy: Nucleic Acids, 2019
Long noncoding RNAs (lncRNAs) are involved in a variety of biological processes such as tumor proliferation and metastasis. A close relationship between hepatitis B virus X protein (HBx) and SMYD3 in promoting the proliferation and metastasis of ...
Zheng Chen, Wei Yu, Qiming Zhou, Jianlong Zhang, Hai Jiang, Dake Hao, Jie Wang, Zhenyu Zhou, Chuanchao He, Zhiyu Xiao   +9 more
doaj   +1 more source

SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression

Scientific Reports, 2017
SMYD3 is a methyltransferase highly expressed in many types of cancer. It usually functions as an oncogenic protein to promote cell cycle, cell proliferation, and metastasis.
Yun-Ju Chen, Cheng-Hui Tsai, Pin-Yu Wang, Shu-Chun Teng   +3 more
doaj   +1 more source

New open conformation of SMYD3 implicates conformational selection and allostery

AIMS Biophysics, 2016
SMYD3 plays a key role in cancer cell viability, adhesion, migration and invasion. SMYD3 promotes formation of inducible regulatory T cells and is involved in reducing autoimmunity. However, the nearly "closed" substrate-binding site and poor in vitro H3K4 methyltransferase activity have obscured further understanding of this oncogenically related ...
Nicholas Spellmon, Xiaonan Sun, Wen Xue, Joshua Holcomb, Srinivas Chakravarthy, Weifeng Shang, Brian Edwards, Nualpun Sirinupong, Chunying Li, Zhe Yang   +9 more
openaire   +3 more sources

Role of the SMYD3 histone methyltransferase in tumorigenesis [PDF]

Cell Cycle, 2012
Souhila, Medjkane, Alicia, Cock-Rada, Jonathan B, Weitzman   +2 more
openaire   +2 more sources

SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair

Oncogenesis
Endometrial cancer (EC) stands as one of the most prevalent malignancies affecting the female genital tract, witnessing a rapid surge in incidence globally.
Yujia Huang, Ming Tang, Zhiyi Hu, Bailian Cai, Guofang Chen, Lijun Jiang, Yan Xia, Pujun Guan, Xiaoqi Li, Zhiyong Mao, Xiaoping Wan, Wen Lu   +11 more
doaj   +1 more source

Functional analysis of SMYD2 and SMYD3 lysine methyltransferases

, 2016
The proteins SMYD2 and SMYD3 are two of five members of a unique family of lysine methyltransferases defined by a catalytic SET domain that is split into two segments by a MYND protein interaction domain, followed by a cysteine-rich post-SET domain. The SMYD family members have been shown to be essential for cellular development, cell cycle progression,
Edwards, Melissa Ashley, author, Brown, Mark, advisor, Tucker, Haley, committee member, Partin, Kathryn, committee member, Hickey, Matthew, committee member   +4 more
openaire   +2 more sources

SMYD3 wt Allele [PDF]

, 2020
openaire   +1 more source

Retraction notice to "SMYD3 induces sorafenib resistance by activating SMAD2/3-mediated epithelial-mesenchymal transition in hepatocellular carcinoma" [iScience 26 (2023) 106994]. [PDF]

iScience
Wang S, You X, Liu X, Zhang F, Zhou H, Shang X, Cai L.   +6 more
europepmc   +1 more source

Overcoming Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma (HNSCC): The Role of Histone Methyltransferase and Demethylase Inhibitors. [PDF]

Cancers (Basel)
Adamczuk K, Miziak P, Adamczuk G, Baran M, Nees M, Stepulak A.   +5 more
europepmc   +1 more source