Results 81 to 90 of about 1,974 (156)
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 4, June 2025.ABSTRACT Externalizing traits and behaviors are broadly defined by impairments in self‐regulation and impulse control that typically begin in childhood and adolescence. Externalizing behaviors, traits, and symptoms span a range of traditional psychiatric diagnostic categories.
India A. Reddy +5 more
wiley +1 more source
Uncovering Genetic Variation in Systemic Lupus Erythematosus Risk Variants in Indigenous Peruvians
ACR Open Rheumatology, Volume 7, Issue 5, May 2025.Objective Systemic lupus erythematosus (SLE) results in worse clinical outcomes among individuals of Amerindian descent. The genetic basis for this is uncertain, and there is a significant lack of genetic research focused on Amerindian ancestry populations.
Cristina M. Lanata +9 more
wiley +1 more source
Effect of SMYD3 on Biological Behavior and H3K4 Methylation in Bladder Cancer [Retraction]
Cancer Management and Research, 2023 Wu X, Xu Q, Chen P, et al. Cancer Manag Res. 2019;11:8125–8133. We, the Editor and Publisher of Cancer Management and Therapy are retracting the published article.
Wu X +6 more
doaj
Molecular Therapy: Nucleic Acids, 2019 Long noncoding RNAs (lncRNAs) are involved in a variety of biological processes such as tumor proliferation and metastasis. A close relationship between hepatitis B virus X protein (HBx) and SMYD3 in promoting the proliferation and metastasis of ...
Zheng Chen +9 more
doaj +1 more source
SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression
Scientific Reports, 2017 SMYD3 is a methyltransferase highly expressed in many types of cancer. It usually functions as an oncogenic protein to promote cell cycle, cell proliferation, and metastasis.
Yun-Ju Chen +3 more
doaj +1 more source
Functional analysis of SMYD2 and SMYD3 lysine methyltransferases
, 2016 The proteins SMYD2 and SMYD3 are two of five members of a unique family of lysine methyltransferases defined by a catalytic SET domain that is split into two segments by a MYND protein interaction domain, followed by a cysteine-rich post-SET domain. The SMYD family members have been shown to be essential for cellular development, cell cycle progression,
Edwards, Melissa Ashley, author +4 more
openaire +2 more sources
New open conformation of SMYD3 implicates conformational selection and allostery
AIMS Biophysics, 2016 SMYD3 plays a key role in cancer cell viability, adhesion, migration and invasion. SMYD3 promotes formation of inducible regulatory T cells and is involved in reducing autoimmunity. However, the nearly "closed" substrate-binding site and poor in vitro H3K4 methyltransferase activity have obscured further understanding of this oncogenically related ...
Nicholas Spellmon +9 more
openaire +3 more sources
Role of the SMYD3 histone methyltransferase in tumorigenesis [PDF]
Cell Cycle, 2012 Souhila, Medjkane +2 more
openaire +2 more sources
Glycogen for Smyd3-antisense oligonucleotide delivery and enhanced liver cancer gene therapy. [PDF]
RSC AdvBai N +5 more
europepmc +1 more source