Results 91 to 100 of about 51,201 (249)

Atrase A, a P-III class metalloproteinase purified from cobra venom, exhibits potent anticoagulant activity by inhibiting coagulation pathway and activating the fibrinolytic system

Heliyon
Snake venoms, comprising a complex array of protein-rich components, an important part of which are snake venom metalloproteinases (SVMPs). These SVMPs, which are predominantly isolated from viperid venoms, are integral to the pathology of snakebites ...
Xin-Jie Zhong, Cai-E Wang, Ya-Nan Li, Qi-Yun Zhang, Qian-Yun Sun   +4 more
doaj   +1 more source

Maternal IgE Influence on Fetal and Infant Health

Immunological Reviews, Volume 331, Issue 1, May 2025.
ABSTRACT Immunoglobulin E (IgE) is the most recently discovered and evolved mammalian antibody type, best known for interacting with mast cells (MCs) as immune effectors. IgE‐mediated antigen sensing by MC provides protection from parasites, venomous animals, bacteria, and other insults to barrier tissues exposed to the environment.
Jozef Balla, Abhay P. S. Rathore, Ashley L. St. John   +2 more
wiley   +1 more source

Proteomic Characterization of Two Medically Important Malaysian Snake Venoms, Calloselasma rhodostoma (Malayan Pit Viper) and Ophiophagus hannah (King Cobra)

Toxins, 2018
Calloselasma rhodostoma (CR) and Ophiophagus hannah (OH) are two medically important snakes found in Malaysia. While some studies have described the biological properties of these venoms, feeding and environmental conditions also influence the ...
Sugita Kunalan, Iekhsan Othman, Sharifah Syed Hassan, Wayne C. Hodgson   +3 more
doaj   +1 more source

Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A [PDF]

, 2009
Background It has been recognized that phospholipase A2 (PLA2) is a crucial component of snake venom, which contributes greatly to snake venom induced inflammation in man. However, the mechanisms through which N49 PLA2 provoke inflammation remain unclear.
Ji-Fu Wei, Xiao-Long Wei, Ya-Zhen Mo, Shao-Heng He   +3 more
core   +2 more sources

Discovery of HY•1: A Novel Multifunctional Skincare Ingredient With Antiaging and Skin Repair Properties

Journal of Cosmetic Dermatology, Volume 24, Issue 5, May 2025.
ABSTRACT Objectives Skin aging, influenced by intrinsic and extrinsic factors, includes photoaging caused by UV radiation, leading to ROS production and skin damage. The objective of this work is to demonstrate HY‐1, a three‐peptide conjugate shown to have antioxidation, anti‐inflammatory efficacy in vitro, and clinical benefits in anti‐wrinkle, is an ...
Xilei Duan, Zhong Lu
wiley   +1 more source

Distinct regulatory networks control toxin gene expression in elapid and viperid snakes

BMC Genomics
Background Venom systems are ideal models to study genetic regulatory mechanisms that underpin evolutionary novelty. Snake venom glands are thought to share a common origin, but there are major distinctions between venom toxins from the medically ...
Cassandra M. Modahl, Summer Xia Han, Jory van Thiel, Candida Vaz, Nathan L. Dunstan, Seth Frietze, Timothy N. W. Jackson, Stephen P. Mackessy, R. Manjunatha Kini   +8 more
doaj   +1 more source

CcMP-II Metalloproteinase from Cerastes Cerastes Snake Venom Acts both on Blood Vessel ECM and Platelets

, 2020
Background: Snake venoms contain various metalloproteinases that are highly toxic, inducing in severe bleeding by interfering with the blood coagulation and degrading the basement membrane or extracellular matrix (ECM) components.
Amel Bennacer
semanticscholar   +1 more source

Biochemical and Biological Profiles of Bangladeshi Russell’s Viper Snake Venom and Neutralizing Efficacy by Indian VINS Polyvalent Antivenom

Journal of Toxicology, Volume 2025, Issue 1, 2025.
The Russell’s viper (Daboia russelii) has recently become a significant threat to human life in Bangladesh. Given its wide distribution across South Asia, the venom characteristics and lethality can vary by region with different toxicological properties.
Rubait Hasan, Hasanuzzaman Manik, Md Ataur Rahman, Jamiatul Husna Shathi, Md Tariqul Islam, Mohammad Shahangir Biswas, Kazi Md. Faisal Hoque, Phuping Sucharitakul   +7 more
wiley   +1 more source

Proteomic Characterization and Comparison of Malaysian Tropidolaemus wagleri and Cryptelytrops purpureomaculatus Venom Using Shotgun-Proteomics

Toxins, 2016
Tropidolaemus wagleri and Cryptelytrops purpureomaculatus are venomous pit viper species commonly found in Malaysia. Tandem mass spectrometry analysis of the crude venoms has detected different proteins in T. wagleri and C. purpureomaculatus.
Syafiq Asnawi Zainal Abidin, Pathmanathan Rajadurai, Md Ezharul Hoque Chowdhury, Muhamad Rusdi Ahmad Rusmili, Iekhsan Othman, Rakesh Naidu   +5 more
doaj   +1 more source

Role of accelerated segment switch in exons to alter targeting (ASSET) in the molecular evolution of snake venom proteins [PDF]

, 2009
BACKGROUND: Snake venom toxins evolve more rapidly than other proteins through accelerated changes in the protein coding regions. Previously we have shown that accelerated segment switch in exons to alter targeting (ASSET) might play an important role in
Robin Doley, Stephen P Mackessy, R Manjunatha Kini   +2 more
core   +2 more sources