Results 171 to 180 of about 34,979 (216)

Systemic Envenomation via Ocular Route from a Neurotoxic Snake Venom Ophthalmia--A Case Report. [PDF]

J Acute Med
Rodriguez GJD, Sabueto CAP, Custodio DAR, Nogas EJL.   +3 more
europepmc   +1 more source

Report from the 31st Meeting on Toxinology, "Toxins: Playing with and Fighting Them!", Organized by the French Society for Toxinology on 1-2 December 2025. [PDF]

Toxins (Basel)
Diochot S, Le Garrec R, Dugon MM, Marchot P.   +3 more
europepmc   +1 more source

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Evidence for heterogeneous forms of the snake venom metalloproteinase jararhagin: a factor contributing to snake venom variability

Archives of Biochemistry and Biophysics, 2003
The reprolysin subfamily of metalloproteinases includes snake venom metalloproteinases (SVMP) and mammalian disintegrin/metalloproteinase. These proteins are synthesized as zymogens and undergo proteolytic processing resulting in a variety of multifunctional proteins. Jararhagin is a P-III SVMP isolated from the venom of Bothrops jararaca.
Ana M Moura-Da-Silva, Anthony S David, Marina T Assakura   +2 more
exaly   +3 more sources

Isolation and cloning of a metalloproteinase from king cobra snake venom

Toxicon, 2007
A 50 kDa fibrinogenolytic protease, ohagin, from the venom of Ophiophagus hannah was isolated by a combination of gel filtration, ion-exchange and heparin affinity chromatography. Ohagin specifically degraded the alpha-chain of human fibrinogen and the proteolytic activity was completely abolished by EDTA, but not by PMSF, suggesting it is a ...
Wen-Hui Lee
exaly   +3 more sources

Snake venom metalloproteinases

Toxicon, 2013
Recent proteomic analyses of snake venoms show that metalloproteinases represent major components in most of the Crotalid and Viperid venoms. In this chapter we discuss the multiple activities of the SVMPs. In addition to hemorrhagic activity, members of the SVMP family also have fibrin(ogen)olytic activity, act as prothrombin activators, activate ...
Francis S, Markland, Stephen, Swenson
openaire   +2 more sources

Hemorrhagic metalloproteinases from snake venoms

Pharmacology & Therapeutics, 1994
One of the more significant consequences of crotalid envenomation is hemorrhage. Over the past 50 years of investigation, it is clear that the primary factors responsible for hemorrhage are metalloproteinases present in the venom of these snakes.
J B, Bjarnason, J W, Fox
openaire   +2 more sources

Natural Inhibitors of Snake Venom Metalloproteinases

Australian Journal of Chemistry, 2020
Snakebites are a hazard in the tropical world. Although antivenom therapy is effective, it is beset with inherent drawbacks. A better understanding of the major components of snake venoms and their neutralisation will help in improving snakebite treatment.
Narumi Aoki-Shioi, Cho Yeow Koh, R. Manjunatha Kini   +2 more
openaire   +1 more source

Unraveling the Processing and Activation of Snake Venom Metalloproteinases

Journal of Proteome Research, 2014
Snake venom metalloproteinases (SVMPs) are zinc-dependent enzymes responsible for most symptoms of human envenoming. Like matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase (ADAM) proteins, SVMPs are synthesized as zymogens, and enzyme activation is regulated by hydrolysis of their prodomain, but the processing of SVMPs is still ...
José A, Portes-Junior, Norma, Yamanouye, Sylvia M, Carneiro, Paloma S, Knittel, Sávio S, Sant'Anna, Fabio C S, Nogueira, Magno, Junqueira, Geraldo S, Magalhães, Gilberto B, Domont, Ana M, Moura-da-Silva   +9 more
openaire   +2 more sources

Natural inhibitors of snake venom hemorrhagic metalloproteinases

Toxicon, 2005
Metalloproteinases play an important role in the poisoning process by snake venoms. They evoke systemic injury, by degrading or activating host blood factors, and local damage by acting on endothelial cell surface proteins. Plasma and/or muscle of venomous and non-venomous snakes as well as of some special mammals possess metalloproteinase inhibitors ...
Jonas, Perales, Ana G C, Neves-Ferreira, Richard H, Valente, Gilberto B, Domont   +3 more
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Triacontyl p-coumarate: An inhibitor of snake venom metalloproteinases

Phytochemistry, 2013
Snake venom metalloproteinases (SVMPs) participate in a number of important biological, physiological and pathophysiological processes and are primarily responsible for the local tissue damage characteristic of viperid snake envenomations. The use of medicinal plant extracts as antidotes against animal venoms is an old practice, especially against ...
Mendes, M. M., Vieira, S. A P B, Gomes, M. S R, Paula, V. F., Alcântara, T. M., Homsi-Brandeburgo, M. I., Dos Santos, J. I., Magro, A. J., Fontes, M. R M, Rodrigues, V. M.   +9 more
openaire   +3 more sources