Results 61 to 70 of about 14,870 (188)

Protein design and RNA design: Perspectives

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley   +1 more source

Factors underlying the natural resistance of animals against snake venoms

Memorias do Instituto Oswaldo Cruz, 1989
The existence of mammals and reptilia with a natural resistance to snake venoms is known since a long time. This fact has been subjected to the study by several research workers.
H. Moussatché, J. Perales
doaj   +1 more source

The many dimeric faces of Lys49 PLA2‐like proteins: Conformational plasticity and membrane binding drive functional dimer states

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Lys49 secreted phospholipase A2‐like proteins (sPLA2s) are major myotoxins in viperid snake venoms, causing rapid muscle damage in envenomation. Beyond their clinical relevance, these small non‐catalytic proteins provide a model to study how quaternary structure and conformational dynamics enable catalysis‐independent membrane disruption ...
Diane C. A. Lima, Vinicius Firmino dos Santos, Bernardo Rassi, Richard J. Ward, Thereza A. Soares   +4 more
wiley   +1 more source

ProteinDJ: A high‐performance and modular protein design pipeline

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Leveraging artificial intelligence and deep learning to generate proteins de novo (a.k.a. ‘synthetic proteins’) has unlocked new frontiers of protein design. Deep learning models trained on protein structures can generate novel protein designs that explore structural landscapes unseen by evolution.
Dylan Silke, Julie Iskander, Junqi Pan, Andrew P. Thompson, Anthony T. Papenfuss, Isabelle S. Lucet, Joshua M. Hardy   +6 more
wiley   +1 more source

Composition efficacy of Unsaturated Arachidonic acid, Diterpenoids, Malvin (C ₂₉ H ₃₅ ClO ₁₇ ), and Bergenin to neutralise venom from different venomous snake species [PDF]

, 2022
Lujaina N. H. Al-Tobi, Juma.Z.K Albusaidi, Ali.A Ajabri, Mohammed A. Idris, Sidgi S. Hasson   +4 more
openalex   +1 more source

Tackling High Dimensionality in QSP: Guiding Model Order Reduction With Index Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Quantitative systems pharmacology (QSP) models offer a useful platform to integrate drug pharmacology with knowledge about biological mechanisms across multiple scales and data sources into a unified quantitative framework. This makes them invaluable to address many relevant questions in drug research and development.
Johannes Tillil, Wilhelm Huisinga, Jane Knöchel   +2 more
wiley   +1 more source

Cytotoxicity of Southeast Asian snake venoms

Journal of Venomous Animals and Toxins including Tropical Diseases, 2012
Cytotoxicity of venoms from eleven medically important snakes found in Southeast Asia (Naja kaouthia, Naja siamensis, Naja sumatrana, Ophiophagus hannah, Bungarus candidus, Bungarus fasciatus, Enhydrina schistosa, Calloselasma rhodostoma, Trimeresurus ...
A Jamunaa, J Vejayan, I Halijah, SH Sharifah, S Ambu   +4 more
doaj   +1 more source

An integrated social–ecological–evolutionary–phenotypic (SEEP) approach to understanding animal responses to urbanization

Biological Reviews, Volume 101, Issue 1, Page 419-436, February 2026.
ABSTRACT Humans play key roles in shaping the structure and processes of ecosystems globally, especially in cities. This recognition has prompted a recent focus on understanding urban systems via interactions between human social systems and ecological and evolutionary processes.
Kevin E. McCluney, Pierre Deviche, Karen L. Sweazea, Elizabeth J. Carlen, Jeffrey A. G. Clark, Aaron M. Grade, Jeffrey D. Haight, Chase Niesner, Shaylynn Trego, Katherine C.B. Weiss   +9 more
wiley   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
wiley   +1 more source

Does Biomass Fuel Use for Cooking Affect Early Childhood Development? A Case Study of Kiribati

Asia &the Pacific Policy Studies, Volume 13, Issue 1, January 2026.
ABSTRACT Early childhood development sets the starting point for future health, learning, and wellbeing; hence, the United Nations Sustainable Development Goals (SDGs) recognise the importance of early childhood development in the global agenda. Therefore, we present evidence of the possible influence of prolonged biomass use for cooking on early ...
Ashar Awan, Dil B. Rahut, Faisal Azeem Abbassi   +2 more
wiley   +1 more source