Results 111 to 120 of about 150,506 (397)
α-SNAP Enhances SNARE Zippering by Stabilizing the SNARE Four-Helix Bundle
Cell Reports, 2016 Intracellular membrane fusion is mediated by dynamic assembly and disassembly of soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptors (SNAREs). α-SNAP guides NSF to disassemble SNARE complexes after membrane fusion.
Lu Ma +7 more
doaj +1 more source
En route to dynamic life processes by SNARE-mediated fusion of polymer and hybrid membranes [PDF]
, 2021 Lado Otrin +13 more
openalex +1 more source
Mechanistic insights into the SNARE complex disassembly
Science Advances, 2019 Near-atomic resolution structure of the 20S complex reveals the mechanism of α-SNAP mediated disassembly of the SNARE complex. NSF (N-ethylmaleimide–sensitive factor) and α-SNAP (α–soluble NSF attachment protein) bind to the SNARE (soluble NSF attachment
Xuan Huang +10 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
eLife, 2020 Vesicle fusion is mediated by assembly of SNARE proteins between opposing membranes. While previous work suggested an active role of SNARE transmembrane domains (TMDs) in promoting membrane merger (Dhara et al., 2016), the underlying mechanism remained ...
Madhurima Dhara +5 more
doaj +1 more source
The multi-functional SNARE protein Ykt6 in autophagosomal fusion processes
Cell Cycle, 2019 Autophagy is a degradative pathway in which cytosolic material is enwrapped within double membrane vesicles, so-called autophagosomes, and delivered to lytic organelles.
Franziska Kriegenburg +4 more
semanticscholar +1 more source
A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells [PDF]
, 2008 Mannose 6-phosphate receptors (MPRs) are transported from endosomes to the Golgi after delivering lysosomal enzymes to the endocytic pathway. This process requires Rab9 guanosine triphosphatase (GTPase) and the putative tether GCC185.
Espinosa, Eric +2 more
core +4 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
In situ formation of the loop snare technique for retrieval of foreign bodies from vessels
Journal of Interventional Medicine, 2018 Purpose: To investigate the feasibility and effectiveness of in situ formation of the loop snare technique for retrieval of foreign bodies from vessels.Materials and methods: We retrospectively reviewed in situ formation of the loop snare technique for ...
Qi Wang +5 more
doaj +1 more source