Results 151 to 160 of about 12,300 (184)

The effect of SNCA 3′ region on the levels of SNCA-112 splicing variant [PDF]

Neurogenetics, 2010
Genetic variability at the 3' region of SNCA locus has been repeatedly associated with susceptibility to sporadic Parkinson's disease (PD). Accumulated evidence emphasizes the importance of SNCA dosage and expression levels in PD pathogenesis. However, the mechanism through which the 3' region of SNCA gene modulates the risk to develop sporadic PD ...
James R Burke, Ornit Chiba-Falek
exaly   +3 more sources

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Exacerbated synucleinopathy in mice expressing A53T SNCA on a Snca null background

Neurobiology of Aging, 2005
Alpha-Synuclein is a major component of Lewy bodies, neuronal inclusions diagnostic for Parkinson's disease (PD). While an Ala53Thr mutation in alpha-synuclein can cause PD in humans, in mice the wildtype residue at position 53 is threonine, indicating that mice are either too short-lived to develop PD, or are protected by the six other amino acid ...
Deborah E, Cabin, Suzana, Gispert-Sanchez, Diane, Murphy, Georg, Auburger, Robert R, Myers, Robert L, Nussbaum   +5 more
openaire   +2 more sources

SNCA REP1 and Parkinson’s disease

Neuroscience Letters, 2018
REP1 is a polymorphic dinucleotide repeat sequence located in the promoter region of the SNCA gene (OMIM 163890). Opinions regarding the interaction between the various REP1 alleles and Parkinson's disease (PD) or its phenotypes have been inconsistent and have thus far not been comprehensively analyzed.
Li Shu, Yuan Zhang, Qiying Sun, Hongxu Pan, Jifeng Guo, Beisha Tang   +5 more
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Genetic variability in SNCA and Parkinson’s disease

neurogenetics, 2011
Over the last decades, increasing knowledge about the genetic architecture of Parkinson's disease has provided novel insights into the pathogenesis of the disorder, generating hypotheses for further research. Characterizing the role of SNCA, encoding the α-synuclein protein, has been a particularly important aspect of this development.
Lasse, Pihlstrøm, Mathias, Toft
openaire   +2 more sources

The link between the SNCA gene and parkinsonism

Neurobiology of Aging, 2015
The groundbreaking discovery of mutations in the SNCA gene in a rare familial form of Parkinson's disease (PD) has revolutionized our basic understanding of the etiology of PD and other related disorders. Genome-wide Association Studies has demonstrated a wide array of single-nucleotide polymorphisms associated with the increasing risk of developing ...
Wei, Xu, Lan, Tan, Jin-Tai, Yu
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Up-regulation of SNCA gene expression: implications to synucleinopathies [PDF]

Neurogenetics, 2016
Synucleinopathies are a group of neurodegenerative diseases that share a common pathological lesion of intracellular protein inclusions largely composed by aggregates of alpha-synuclein protein. Accumulating evidence, including genome wide association studies, has implicated alpha-synuclein (SNCA) gene in the etiology of synucleinopathies. However, the
L, Tagliafierro, O, Chiba-Falek
exaly   +3 more sources

SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma [PDF]

Genes, 2018
There is increasing evidence for the contribution of synuclein alpha (SNCA) to the etiology of neurological disorders, such as Parkinson’s disease (PD). However, little is known about the detailed role of SNCA in human cancers, especially lung cancers.
Yuanliang Yan, Zhijie Xu, Xiaofang Hu
exaly   +3 more sources

SNCA polymorphisms, smoking, and sporadic Parkinson’s disease in Japanese

Parkinsonism & Related Disorders, 2012
Several case-control studies and genome-wide association studies have examined the relationships between single nucleotide polymorphisms (SNPs) in the SNCA gene and Parkinson's disease (PD), and have provided inconsistent results. We investigated the relationships between SNPs rs356229, rs356219, rs356220, rs7684318, and rs2736990 and the risk of ...
Yoshihiro, Miyake, Keiko, Tanaka, Wakaba, Fukushima, Chikako, Kiyohara, Satoshi, Sasaki, Yoshio, Tsuboi, Tatsuo, Yamada, Tomoko, Oeda, Hiroyuki, Shimada, Nobutoshi, Kawamura, Nobutaka, Sakae, Hidenao, Fukuyama, Yoshio, Hirota, Masaki, Nagai   +13 more
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Association of Alcohol Craving With α‐Synuclein (SNCA)

Alcoholism: Clinical and Experimental Research, 2007
Background: Studies have found that genomic variation in the gene SNCA, which encodes the protein α‐synuclein, may contribute to the variation in alcohol consumption in an inbred rat model of alcohol preference. Studies in humans have provided support for an association between SNCA and craving for alcohol.Methods: To examine the role of this gene in
Tatiana, Foroud, Leah Flury, Wetherill, Tiebing, Liang, Danielle M, Dick, Victor, Hesselbrock, John, Kramer, John, Nurnberger, Marc, Schuckit, Lucinda, Carr, Bernice, Porjesz, Xiaoling, Xuei, Howard J, Edenberg   +11 more
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Expanding the clinical phenotype of SNCA duplication carriers

Movement Disorders, 2009
AbstractSNCA duplication is a recognized cause of familial Parkinson's disease (PD). We aimed to explore the genetic and clinical variability in the disease manifestation. Molecular characterization was performed using real‐time PCR, SNP arrays, and haplotype analysis.
Kenya, Nishioka, Owen A, Ross, Kenji, Ishii, Jennifer M, Kachergus, Kiichi, Ishiwata, Mayumi, Kitagawa, Satoshi, Kono, Tomokazu, Obi, Koichi, Mizoguchi, Yuichi, Inoue, Hisamasa, Imai, Masashi, Takanashi, Yoshikuni, Mizuno, Matthew J, Farrer, Nobutaka, Hattori   +14 more
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