Results 161 to 170 of about 12,300 (184)

Interaction between SNCA gene polymorphisms and T2DM with Parkinson’s disease

Acta Neurologica Scandinavica, 2020
To investigate the association of several single nucleotide polymorphisms (SNPs) within alpha-synuclein (SNCA) gene and additional gene-environment interaction with Parkinson's disease (PD) risk.Hardy-Weinberg equilibrium (HWE) is tested for controls using SNPstats (http://bioinfo.iconcologia.net/SNPstats).
Yajun Liu, Hongying Bai, Shuang Gen, Hui Zhang, Shanshan Wang, Linlin Hua, Xiaopeng Yang, Simiao Zhang, Jingna Li, Yunliang Wang   +9 more
openaire   +2 more sources

SNCA Rep1 promoter variability influences cognition in Parkinson's disease

Movement Disorders, 2019
AbstractBackgroundWhile the association between alpha‐synuclein gene promoter (Rep1) variability and risk of PD is well established, its association with cognition is unclear.ObjectivesTo investigate the association between Rep1 and motor and cognitive outcomes in PD.MethodsRep1 allele lengths were determined in 172 PD patients who were grouped into ...
Adeline S.L. Ng, Yi Jayne Tan, Yi Zhao, Seyed Ehsan Saffari, Zhonghao Lu, Ebonne Y.L. Ng, Samuel Y.E. Ng, Nicole S.Y. Chia, Fiona Setiawan, Zheyu Xu, Kay Yaw Tay, Wing Lok Au, Louis C.S. Tan, Eng‐King Tan   +13 more
openaire   +2 more sources

NeuronalSNCAtranscription during Lewy body formation

2023
ABSTRACTBackgroundMisfolded α-synuclein (α-syn) is believed to contribute to neurodegeneration in Lewy body disease (LBD) based on considerable evidence including a gene-dosage effect observed in relation to point mutations and multiplication ofSNCAin familial Parkinson’s disease.
Tomoya Kon, Shelley L. Forrest, Seojin Lee, Ivan Martinez-Valbuena, Jun Li, Nasna Nassir, Mohammed J. Uddin, Anthony E. Lang, Gabor G. Kovacs   +8 more
openaire   +1 more source

Genetic variants and animal models in SNCA and Parkinson disease

Ageing Research Reviews, 2014
Parkinson disease (PD; MIM 168600) is the second most common progressive neurodegenerative disorder characterized by a variety of motor and non-motor features. To date, at least 20 loci and 15 disease-causing genes for parkinsonism have been identified. Among them, the α-synuclein (SNCA) gene was associated with PARK1/PARK4.
Hao, Deng, Lamei, Yuan
openaire   +2 more sources

[Inheritance mechnisam of gene SNCA for alcohol dependence].

Yi chuan = Hereditas, 2011
SNCA gene is located in a quantitative trait locus for alcohol preference. Alpha-synuclein coded by SNCA gene can regulate the function of dopamine in multiple levels, and dopamine is an important neurotransmitter in alcohol preference. Variation has been found in SNCA gene carried by alcohol-dependent patients.
Yong-Qiang, Yang, Fan, Li
openaire   +1 more source

α‐Synuclein antisense transcript SNCA‐AS1 regulates synapses‐ and aging‐related genes suggesting its implication in Parkinson's disease

Aging Cell, 2021
Bianca Barzaghini, Manuela Teresa Raimondi, Cristina Cereda   +2 more
exaly  

α-synuclein (SNCA)

Science-Business eXchange, 2014
openaire   +1 more source

HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression

Autophagy, 2014
Ju-Xian Song, Jia-Hong Lu, Siva-Sundara Kumar Durairajan   +2 more
exaly  

SNCA

2011
openaire   +1 more source

Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment

Autophagy, 2014
Wei Xiang, Tiago Fleming Outeiro, Jochen Klucken   +2 more
exaly