Results 51 to 60 of about 3,236 (202)

Improving the biopharmaceutical attributes of mangiferin using vitamin E-TPGS co-loaded self-assembled phosholipidic nano-mixed micellar systems [PDF]

, 2018
The current research work encompasses the development, characterization, and evaluation of self-assembled phospholipidic nano-mixed miceller system (SPNMS) of a poorly soluble BCS Class IV xanthone bioactive, mangiferin (Mgf) functionalized with co ...
Gaspar, Balan Louis, Katare, O P, Khurana, Rajneet Kaur, Singh, Bhupinder, Singh, Kamalinder K, Welsby, Gail   +5 more
core   +2 more sources

Propolis‐Based Hybrid Nanoflowers as Multifunctional Nanozymes: Structural Integration of Polyphenols for Enhanced Catalytic and Antioxidant Activity

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
ABSTRACT Propolis is a polyphenol‐rich natural resin with well‐documented antioxidant activity; however, its practical application is restricted by poor aqueous solubility and limited stability. Herein, propolis‐based organic–inorganic hybrid nanoflowers (Prp‐Nfs) were synthesized by integrating a propolis extract into a Cu3(PO4)2·3H2O matrix under ...
Cevahir Altinkaynak, Fatih Kirmizikar
wiley   +1 more source

Understanding the effect of lipid formulation loading and ethanol as a diluent on solidification of pitavastatin super-saturable SNEDDS using factorial design approach

Research in Pharmaceutical Sciences, 2019
Solidification of a preconcentrate lipid formulation namely self-nano emulsifying drug delivery system (SNEDDS) is required to achieve feasibility, flexibility, and a new concept of “dry nano-emulsion”.
Ilham Kuncahyo, Syaiful Choiri, Achmad Fudholi, Abdul Rohman, Ronny Martien   +4 more
doaj   +1 more source

Development of Piperine-Loaded Solid Self-Nanoemulsifying Drug Delivery System: Optimization, In-Vitro, Ex-Vivo, and In-Vivo Evaluation

Nanomaterials, 2021
Hypertension is a cardiovascular disease that needs long-term medication. Oral delivery is the most common route for the administration of drugs. The present research is to develop piperine self-nanoemulsifying drug delivery system (PE-SNEDDS) using ...
Ameeduzzafar Zafar, Syed Sarim Imam, Nabil K. Alruwaili, Omar Awad Alsaidan, Mohammed H. Elkomy, Mohammed M. Ghoneim, Sultan Alshehri, Ahmed Mahmoud Abdelhaleem Ali, Khalid Saad Alharbi, Mohd Yasir, Kaveripakkam M. Noorulla, Sami I. Alzarea, Abdullah S. Alanazi   +12 more
doaj   +1 more source

Pengaruh Peningkatan Tween 20 Sebagaisurfaktan Terhadapkarakteristik Dan Kestabilan Fisik Sediaanselfnanoemulsifying Drug Delivery System (Snedds) Simvastatin [PDF]

, 2017
SARI Simvastatin merupakan golongan obat BCS (Biopharmaceutics Classification System) kelas II dengan efek anti kolesterol.Simvastatin memiliki permeabilitas yang baik didalam saluran cerna, namun kelarutannya buruk didalam air.Beberapa sediaan dibuat ...
Ananda, N. C. (Novelia), Sulaiman, T. N. (T), Suwarmi, S. (Suwarmi)   +2 more
core  

Enhancing biopharmaceutical performance of an anticancer drug by long chain PUFA based self-nanoemulsifying lipidic nanomicellar system. [PDF]

, 2017
The aim of this study was to develop polyunsaturated fatty acid (PUFA) long chain glyceride (LCG) enriched self-nanoemulsifying lipidic nanomicelles systems (SNELS) for augmenting lymphatic uptake and enhancing oral bioavailability of docetaxel and ...
Beg, Sarwar, Burrow, Andrea Julie, Katare, O P, Kaur Khurana, Rajneet, Kaur, Satvinder, Kesherwani, Prashant, Singh, Bhupinder, Singh, Kamalinder, Vashishta, Rakesh K   +8 more
core   +1 more source

A Hybrid Nanosystem for Prostate Cancer Therapy: Codelivery of Enzalutamide and Curcumin via Selenium‐Embedded Mesoporous Silica and Chitosan Nanoparticles

ChemistryOpen, Volume 15, Issue 3, March 2026.
Herein, solvent extraction was selected for cetyltrimethylammonium bromide removal and the development of optimized Se‐embedded mesoporous silica nanoparticles, which were loaded with enzalutamide. Additionally, to improve the anticancer activity of Se@MSNPs‐Enz and curcumin bioavailability, curcumin‐loaded chitosan nanoparticles were prepared. This pH‐
Zahra Tavakoli, Khosro Khajeh, Bijan Ranjbar   +2 more
wiley   +1 more source

Combined Ramipril and Black Seed Oil Dosage Forms Using Bioactive Self-Nanoemulsifying Drug Delivery Systems (BIO-SNEDDSs)

Pharmaceuticals, 2022
Purpose: Ramipril (RMP)—an angiotensin-converting enzyme (ACE) inhibitor—and thymoquinone (THQ) suffer from poor oral bioavailability. Developing a combined liquid SNEDDS that comprises RMP and black seed oil (as a natural source of THQ) could lead to ...
Ahmad Abdul-Wahhab Shahba, Abdelrahman Y. Sherif, Ehab M. Elzayat, Mohsin Kazi   +3 more
doaj   +1 more source

In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B [PDF]

, 2020
Amphotericin B (AmpB), one of the most commonly used agents in the treatment of severe fungal infections and life-threatening parasitic diseases such as visceral Leishmaniasis, has a negligible oral bioavailability, primarily due to a low solubility and ...
Fatouros, Dimitrios G, Gika, Helen, Kontogiannidou, Eleni, Meikopoulos, Thomas, Müllertz, Anette, Panteris, Emmanuel, Vizirianakis, Ioannis S   +6 more
core   +1 more source

SNEDDS AS LIPID-BASED NANOCARRIER SYSTEMS: CONCEPTS AND FORMULATION INSIGHTS

International Journal of Applied Pharmaceutics, 2022
Approximately 40 % of newly discovered chemical entities have low solubility and possess low bioavailability after oral administration. Lipid-based drug delivery systems (LBDDS) have recently become very popular because of their remarkable ability to deliver drugs with poor absorption using lipids as carriers.
LAKSHMI DEVI GOTTEMUKKULA, SUNITHA SAMPATHI   +1 more
openaire   +1 more source