Results 1 to 10 of about 644,536 (348)

Cannabidiol interactions with voltage-gated sodium channels

eLife, 2020
Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of two
Lily Goodyer Sait, Altin Sula, Mohammad-Reza Ghovanloo, David Hollingworth, Peter C Ruben, BA Wallace   +5 more
doaj   +2 more sources

How Sodium and Calcium Ions Pass Through Batrachotoxin-Bound Sodium Channel [PDF]

Toxins
Steroidal sodium channel agonist batrachotoxin (BTX), one of the most potent animal toxins, dramatically increases calcium permeation and alters other channel characteristics.
Boris S. Zhorov
doaj   +2 more sources

The Cardiac Sodium Channel Safety Profile of Cenobamate at Therapeutic Concentrations: In Vitro Analyses [PDF]

Clinical and Translational Science
The US Food and Drug Administration (FDA) issued a Drug Safety Communication for the antiseizure drug lamotrigine (Lamictal), warning of the risk of QRS prolongation and cardiac arrhythmias.
William J. Crumb Jr, Susan M. Melnick, Kelli J. Glenn   +2 more
doaj   +2 more sources

Molecular basis of sodium channel inactivation [PDF]

Nature Communications
Voltage-gated sodium channels initiate action potentials and control electrical signaling throughout the animal kingdom. Fast inactivation is an essential auto-inhibitory mechanism and requisite component of sodium channel physiology.
Yichen Liu, Jason D. Galpin, Christopher A. Ahern, Francisco Bezanilla   +3 more
doaj   +2 more sources

Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

BMC Neurology, 2021
Background Many antiseizure medications (ASMs) control seizures by blocking voltage-dependent sodium channels. Polymorphisms of sodium channel genes may affect the response to ASMs due to altering the effect of ASMs on blocking sodium channels.
Chih-Hsiang Lin, Chen-Jui Ho, Yan-Ting Lu, Meng-Han Tsai   +3 more
doaj   +1 more source

Sodium channels [PDF]

Brain and Neuroscience Advances, 2018
In 2000, with the completion of the human genome project, nine related channels were found to comprise the complete voltage-gated sodium gene family and they were renamed NaV1.1–NaV1.9. This millennial event reflected the extraordinary impact of molecular genetics on our understanding of electrical signalling in the nervous system.
Wood, JN, Iseppon, F
openaire   +3 more sources

Highly Sensitive and Selective Sodium Ion Sensor Based on Silicon Nanowire Dual Gate Field-Effect Transistor

Sensors, 2021
In this study, a highly sensitive and selective sodium ion sensor consisting of a dual-gate (DG) structured silicon nanowire (SiNW) field-effect transistor (FET) as the transducer and a sodium-selective membrane extended gate (EG) as the sensing unit was
Seong-Kun Cho, Won-Ju Cho
doaj   +1 more source

Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy

Frontiers in Neuroscience, 2023
Developmental and epileptic encephalopathies (DEEs) are severe seizure disorders with inadequate treatment options. Gain- or loss-of-function mutations of neuronal ion channel genes, including potassium channels and voltage-gated sodium channels, are ...
Sophie F. Hill, Sophie F. Hill, Paymaan Jafar-Nejad, Frank Rigo, Miriam H. Meisler, Miriam H. Meisler, Miriam H. Meisler   +6 more
doaj   +1 more source

A governance of ion selectivity based on the occupancy of the “beacon” in one- and four-domain calcium and sodium channels

Channels, 2023
One of nature’s exceptions was discovered when a Cav3 T-type channel was observed to switch phenotype from a calcium channel into a sodium channel by neutralizing an aspartate residue in the high field strength (HFS) +1 position within the ion ...
J. David Spafford
doaj   +1 more source

Voltage Gated Sodium Channel Genes in Epilepsy: Mutations, Functional Studies, and Treatment Dimensions

Frontiers in Neurology, 2021
Genetic epilepsy occurs as a result of mutations in either a single gene or an interplay of different genes. These mutations have been detected in ion channel and non-ion channel genes. A noteworthy class of ion channel genes are the voltage gated sodium
Ibitayo Abigail Ademuwagun, Ibitayo Abigail Ademuwagun, Solomon Oladapo Rotimi, Solomon Oladapo Rotimi, Steffen Syrbe, Yvonne Ukamaka Ajamma, Ezekiel Adebiyi, Ezekiel Adebiyi, Ezekiel Adebiyi   +8 more
doaj   +1 more source