Results 11 to 20 of about 644,536 (348)

Excitability constraints on voltage-gated sodium channels. [PDF]

PLoS Computational Biology, 2007
We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels. The primary function of sodium channels is to allow the propagation of action potentials. Since Hodgkin and Huxley, mathematical
Elaine Angelino, Michael P Brenner
doaj   +1 more source

Glutathione accelerates sodium channel inactivation in excised rat axonal membrane patches [PDF]

, 1992
The effects of glutathione were studied on the gating behaviour of sodium channels in membrane patches of rat axons. Depolarizing pulses from –120 to –40 mV elicited sodium currents of up to 500 pA, indicating the simultaneous activation of up to 250 ...
B Neumcke, B Nilius, EM Fenwick, J Patlak, JB Patlak, JP Ruppersberg, M Kohlhardt, M Kohlhardt, M. Strupp, N. Mitrović, P Jonas, P. Grafe, PM Vassilev, R Stämpfli, S. Quasthoff, W Stühmer   +15 more
core   +1 more source

Identification of sodium channel isoforms that mediate action potential firing in lamina I/II spinal cord neurons

Molecular Pain, 2011
Background Voltage-gated sodium channels play key roles in acute and chronic pain processing. The molecular, biophysical, and pharmacological properties of sodium channel currents have been extensively studied for peripheral nociceptors while the ...
Smith Paula L, Mezeyova Janette, Hildebrand Michael E, Salter Michael W, Tringham Elizabeth, Snutch Terrance P   +5 more
doaj   +1 more source

Varicella-Zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line [PDF]

, 2013
Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates ...
A Vafai, BM Bradley, C Bourdon-Wouters, C Han, D Quan, DH Gilden, DW Wareham, Edward G. Rowan, EM Garry, Esther Grinfeld, Fiona Scott, FS Hasnie, FT Scott, G Ashrafi, G. H. Ashrafi, J Fogh, J Lai, JD Markman, JN Wood, Joseph Charles Glorioso, Judith Breuer, MA Hamza, MH Meisler, MJ Craner, MJ Quinlivan, ML Szpara, N Storey, Paul Montague, Peter G. E. Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PR Kinchington, R Dabby, R Mahalingam, RG Dalziel, RL Finnen, S Schünemann, SG Waxman, SJ Medhurst, SM Fleetwood-Walker, TR Cummins, W Peng, WA Catterall, X Zhou   +44 more
core   +3 more sources

Altered sodium channel-protein associations in critical illness myopathy

Skeletal Muscle, 2012
Background During the acute phase of critical illness myopathy (CIM) there is inexcitability of skeletal muscle. In a rat model of CIM, muscle inexcitability is due to inactivation of sodium channels.
Kraner Susan D, Novak Kevin R, Wang Qingbo, Peng Junmin, Rich Mark M   +4 more
doaj   +1 more source

Effect of channel block on the spiking activity of excitable membranes in a stochastic Hodgkin-Huxley model [PDF]

, 2004
The influence of intrinsic channel noise on the spontaneous spiking activity of poisoned excitable membrane patches is studied by use of a stochastic generalization of the Hodgkin-Huxley model.
Chow C C, Clay J R, DeFelice L J, Fox R F, G Schmid, Gammaitoni L, Goldman M S, Hille B, Hodgkin A L, Hänggi P, Hänggi P, I Goychuk, Lecar H, LeMasson G, P Hänggi, Press W H, Skaugen E, Strassberg A F   +17 more
core   +2 more sources

Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNa_v1.2, rNa_v1.4 and rNa_v1.5 alpha subunits

BMC Neuroscience, 2010
Background Antillatoxin (ATX) is a structurally unique lipopeptide produced by the marine cyanobacterium Lyngbya majuscula. ATX activates voltage-gated sodium channel α-subunits at an undefined recognition site and stimulates sodium influx in neurons ...
Gerwick William H, Cao Zhengyu, Murray Thomas F   +2 more
doaj   +1 more source

Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel [PDF]

, 2013
The crystal structure of the open conformation of a bacterial voltage-gated sodium channel pore from Magnetococcus sp. (NaVMs) has provided the basis for a molecular dynamics study defining the channel’s full ion translocation pathway and conductance ...
Bagneris, Claire, Clapham, D.E., DeCaen, P.G., Delling, M., McCusker, Emily C., Ulmschneider, J.P., Ulmschneider, Martin B., Wallace, Bonnie A.   +7 more
core   +1 more source

Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel [PDF]

, 2014
Arginine methylation is a novel post-translational modification within the voltage-gated ion channel superfamily, including the cardiac sodium channel, Naᵥ1.5.
Beltran-Alvarez, Pedro, Brugada, Ramon, Díaz-Hernández, Rubí, Feixas, Ferran, Osuna, Sílvia, Pagans, Sara   +5 more
core   +2 more sources

Energetics of discrete selectivity bands and mutation-induced transitions in the calcium-sodium ion channels family [PDF]

, 2013
We use Brownian dynamics (BD) simulations to study the ionic conduction and valence selectivity of a generic electrostatic model of a biological ion channel as functions of the fixed charge Qf at its selectivity filter.
Eisenberg, Robert S., Kaufman, Igor, Luchinsky, Dmitrii G., McClintock, Peter V. E., Tindjong, Rodrigue   +4 more
core   +2 more sources