Frontiers in Pharmacology, 2011 Chronic and neuropathic pain constitute significant health problems affecting millions of individuals each year. Pain sensations typically originate in sensory neurons of the peripheral nervous system (PNS) which relay information to the central nervous
Jonathan W. Theile, Theodore R Cummins
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Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates. [PDF]
PLoS Genetics, 2008 In many mammalian neurons, dense clusters of ion channels at the axonal initial segment and nodes of Ranvier underlie action potential generation and rapid conduction.
Alexis S Hill +7 more
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Interpreting the functional role of a novel interaction motif in prokaryotic sodium channels [PDF]
, 2017 Voltage-gated sodium channels enable the translocation of sodium ions across cell membranes and play crucial roles in electrical signaling by initiating the action potential.
Ahern +36 more
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Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior [PDF]
, 2006 The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Baker, MD +8 more
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Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block. [PDF]
PLoS ONE, 2016 Drugs that prolong the heart rate corrected QT interval (QTc) on the electrocardiogram (ECG) by blocking the hERG potassium channel and also block inward currents (late sodium or L-type calcium) are not associated with torsade de pointes (e.g. ranolazine
Jose Vicente +6 more
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Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels [PDF]
, 2008 Antiarrhythmics, anticonvulsants, and local anesthetics target voltage-gated sodium channels, decreasing excitability of nerve and muscle cells. Channel inhibition by members of this family of cationic, hydrophobic drugs relies on the presence of highly ...
Ahern, Christopher A. +3 more
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Sodium Current Measurements in HEK293 Cells
Bio-Protocol, 2013 This protocol is used to measure sodium currents from heterologously transfected cells lines, such as HEK293 cells. Standard whole cell patch clamp technique is used to assess ion channel function. This protocol has been used to study cardiac type Nav1.5
Helena Riuró +5 more
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PLoS Computational Biology, 2021 State-dependent sodium channel blockers are often prescribed to treat cardiac arrhythmias, but many sodium channel blockers are known to have pro-arrhythmic side effects.
Steffen S Docken +2 more
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Fast sodium channel gating supports localized and efficient axonal action potential initiation [PDF]
, 2010 Action potentials (APs) are initiated in the proximal axon of most neurons. In myelinated axons, a 50-times higher sodium channel density in the initial segment compared to the soma may account for this phenomenon.
Bischofberger, Josef +1 more
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The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium [PDF]
, 2009 Cardiac sodium channels are responsible for conduction in the normal and diseased heart. We aimed to investigate regional and transmural distribution of sodium channel expression and function in the myocardium.
A. A. M. Wilde +12 more
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