Results 31 to 40 of about 644,536 (348)

An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids [PDF]

, 2015
We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin.
Amey, Joanna S., Burton, Mark J., Davies, T.G. Emyr, Duce, Ian R., Field, Linda M., Mellor, Ian R., O'Reilly, Andrias O., Puinean, Alin M., Wallace, B.A., Williamson, Martin S.   +9 more
core   +1 more source

Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart.

PLoS ONE, 2011
BackgroundDuchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is associated with severe cardiac complications including cardiomyopathy and cardiac arrhythmias.
Xaver Koenig, Sandra Dysek, Stefanie Kimbacher, Agnes K Mike, Rene Cervenka, Peter Lukacs, Katrin Nagl, Xuan B Dang, Hannes Todt, Reginald E Bittner, Karlheinz Hilber   +10 more
doaj   +1 more source

A Heart Failure-Associated SCN5A Splice Variant Leads to a Reduction in Sodium Current Through Coupled-Gating With the Wild-Type Channel

Frontiers in Physiology, 2021
Nav1.5, encoded by the gene SCN5A, is the predominant voltage-gated sodium channel expressed in the heart. It initiates the cardiac action potential and thus is crucial for normal heart rhythm and function.
Yang Zheng, Yang Zheng, Xiaoping Wan, Dandan Yang, Angelina Ramirez-Navarro, Haiyan Liu, Ji-Dong Fu, Isabelle Deschênes   +7 more
doaj   +1 more source

Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief [PDF]

, 2016
INTRODUCTION: Chronic pain is a massive clinical problem. We discuss the potential of subtype selective sodium channel blockers that may provide analgesia with limited side effects.
Emery, EC, Luiz, AP, Wood, JN
core   +1 more source

New Theoretical Model of Nerve Conduction in Unmyelinated Nerves

Frontiers in Physiology, 2017
Nerve conduction in unmyelinated fibers has long been described based on the equivalent circuit model and cable theory. However, without the change in ionic concentration gradient across the membrane, there would be no generation or propagation of the ...
Tetsuya Akaishi, Tetsuya Akaishi
doaj   +1 more source

Sodium channels and pain [PDF]

Proceedings of the National Academy of Sciences, 1999
Although it is well established that hyperexcitability and/or increased baseline sensitivity of primary sensory neurons can lead to abnormal burst activity associated with pain, the underlying molecular mechanisms are not fully understood. Early studies demonstrated that, after injury to their axons, neurons can display changes in excitability ...
S G, Waxman, S, Dib-Hajj, T R, Cummins, J A, Black   +3 more
openaire   +2 more sources

Epilepsy-Related Slack Channel Mutants Lead to Channel Over-Activity by Two Different Mechanisms

Cell Reports, 2016
Twelve sodium-activated potassium channel (KCNT1, Slack) genetic mutants have been identified from severe early-onset epilepsy patients. The changes in biophysical properties of these mutants and the underlying mechanisms causing disease remain elusive ...
Qiong-Yao Tang, Fei-Fei Zhang, Jie Xu, Ran Wang, Jian Chen, Diomedes E. Logothetis, Zhe Zhang   +6 more
doaj   +1 more source

Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing [PDF]

, 2012
Voltage-gated sodium channels are vital membrane proteins essential for electrical signalling; in humans, they are key targets for the development of pharmaceutical drugs. Here we report the crystal structure of an open-channel conformation of NavMs, the
A Lampert, A Vagin, AJ McCoy, AM Powl, AM Waterhouse, AO O’Reilly, D Ren, D Shaya, DA Doyle, DP Klose, E Blanc, EC McCusker, GM Clayton, IH van Stokkum, J Payandeh, JD Thompson, JG Lees, JG Lees, K Charalambous, K Irie, L Whitmore, M Petrek, M Strong, NA Baker, P Emsley, R Koishi, RA Laskowski, RM Keegan, SB Long, VB Chen, W Kabsch, W Kabsch, Y Zhao, Y Zhao   +33 more
core   +2 more sources

SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons. [PDF]

, 2016
The mechanism for the earliest response of central neurons to hypoxia-an increase in voltage-gated sodium current (INa)-has been unknown. Here, we show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cerebellar granule ...
Goldstein, Steve An, Marks, Jeremy D, Plant, Leigh D   +2 more
core   +2 more sources

Sodium Channel Mutations and Pyrethroid Resistance in Aedes aegypti

Insects, 2016
Pyrethroid insecticides are widely used to control insect pests and human disease vectors. Voltage-gated sodium channels are the primary targets of pyrethroid insecticides.
Yuzhe Du, Yoshiko Nomura, Boris S. Zhorov, Ke Dong   +3 more
doaj   +1 more source