Results 81 to 90 of about 644,536 (348)

Novel Sodium Channel Inhibitor From Leeches

Frontiers in Pharmacology, 2018
Considering blood-sucking habits of leeches from surviving strategy of view, it can be hypothesized that leech saliva has analgesia or anesthesia functions for leeches to stay undetected by the host. However, no specific substance with analgesic function
Gan Wang, Chengbo Long, Weihui Liu, Cheng Xu, Min Zhang, Min Zhang, Qiong Li, Qiumin Lu, Qiumin Lu, Ping Meng, Dongsheng Li, Mingqiang Rong, Mingqiang Rong, Zhaohui Sun, Xiaodong Luo, Ren Lai, Ren Lai   +16 more
doaj   +1 more source

Sodium Channel Auxiliary Subunits

Microbial Physiology, 2007
Voltage-gated ion channels are well known for their functional roles in excitable tissues. Excitable tissues rely on voltage-gated ion channels and their auxiliary subunits to achieve concerted electrical activity in living cells. Auxiliary subunits are also known to provide functional diversity towards the transport and biogenesis properties of the ...
Tsai-Tien, Tseng, Allison M, McMahon, Victoria T, Johnson, Erwin Z, Mangubat, Robert J, Zahm, Mary E, Pacold, Eric, Jakobsson   +6 more
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]

, 2015
Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro, Onwuli, Donatus O.   +1 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene [PDF]

, 2004
Dynamic changes in synaptic connectivity and strength, which occur during both embryonic development and learning, have the tendency to destabilize neural circuits.
Baines, Richard A., Mee, Christopher J., Moffat, Kevin G., Pym, Edward C. G.   +3 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

BIOTEX-biosensing textiles for personalised healthcare management. [PDF]

, 2010
Textile-based sensors offer an unobtrusive method of continually monitoring physiological parameters during daily activities. Chemical analysis of body fluids, noninvasively, is a novel and exciting area of personalized wearable healthcare systems ...
Bini, Christina, Chartier, Isabelle, Chuzel, Cyril, Convert, Reynald, Costanzo, Daniele, Coyle, Shirley, De Rossi, Danilo, De-Moncuit, Henri, Di Francesco, Fabio, Diamond, Dermot, Giovanna Trivella, Maria, Lanier, Thierry, Lau, King-Tong, Luprano, Jean, Mourier, Veronique, Moyna, Niall, O'Gorman, Donal, Paradiso, Rita, Porchet, Jacques-André, Revol-Cavalier, Frederic, Ridofi, Andrea, Salvo, Pietro, Schoumacker, Sébastien, Taccini, Nicola   +23 more
core   +1 more source

Neuroplastic alteration of TTX-resistant sodium channel with visceral pain and morphine-induced hyperalgesia

Journal of Pain Research, 2012
Jinghong Chen,1,2,4 Ze-hui Gong,4 Hao Yan,2 Zhijun Qiao,3 Bo-yi Qin41Department of Internal Medicine, Neuroscience Program, The University of Texas Medical Branch, Galveston, TX, USA; 2The Divisions of Pharmacy, Pharmacology core lab, MD Anderson Cancer ...
Chen J, Gong Z, Yan H, Qiao Z, Qin B
doaj  

Effects of Sodium Azide, Barium Ion, d-Amphetamine and Procaine on Inward Rectifying Potassium Channel 6.2 Expressed in Xenopus Oocytes

Journal of the Formosan Medical Association, 2008
Background/Purpose: Inward rectifying potassium channel 6.2 (Kir6.2 Δ C26 channel) is closely related to ATP-sensitive potassium channels. Whether sodium azide, barium ion, d-amphetamine or procaine acts directly on the Kir6.2 Δ C26 channel remains ...
Fan-Lu Kung, Jung-Lung Tsai, Chien-Hsing Lee, Kuo-Long Lou, Chih-Yung Tang, Horng-Huei Liou, Kuan-Ling Lu, Yi-Hung Chen, Wun-Jheng Wang, Ming-Cheng Tsai   +9 more
doaj   +1 more source