Green spectrofluorimetric method for quantification of sodium oxybate in pharmaceutical and plasma samples [PDF]
Scientific ReportsSodium oxybate is a newly approved oral treatment for narcolepsy-related cataplexy and excessive daytime sleepiness. It has been misused recreationally and implicated in drug-facilitated crimes.
Reem M. Alnemari +8 more
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Long-Term Treatment of Narcolepsy and Idiopathic Hypersomnia with Low-Sodium Oxybate [PDF]
Nature and Science of Sleep, 2023 Logan D Schneider,1 Anne Marie Morse,2 Michael J Strunc,3 Joyce K Lee-Iannotti,4 Richard K Bogan5 1Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA; 2Janet Weis Children’s Hospital, Geisinger ...
Schneider LD +4 more
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Prophylactic effect of intraoperative sodium oxybate on postoperative delirium in older patients undergoing major orthopedic surgery: a randomized clinical trial [PDF]
BMC MedicineBackground Postoperative delirium (POD) represents a significant challenge in perioperative care, particularly among older surgical patients. This acute neuropsychiatric syndrome is associated with prolonged hospitalization, increased mortality, and long-
Meiying Cui +8 more
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Sodium Oxybate: a Substitute for Alcohol? [PDF]
European Psychiatry, 2022 Gamma-hydroxybutyrate (GHB) is a neurotransmitter found naturally in the human brain. Sodium oxybate (SO) is the sodium salt of GHB. In 2000 GHB was classified a Schedule I controlled substance, while SO became a Schedule III controlled substance for ...
A. Gual +3 more
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Once-nightly sodium oxybate (FT218) improved symptoms of disrupted nighttime sleep in people with narcolepsy: a plain language summary [PDF]
Journal of Comparative Effectiveness Research, 2023 What is this summary about? This is a plain language summary of a published article in the journal CNS Drugs. Narcolepsy is a rare sleep condition.
Thomas Roth +4 more
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Sodium Oxybate-Induced secondary mania with psychotic symptoms: a case report and literature review [PDF]
European PsychiatryIntroduction Sodium oxybate, an effective treatment for narcolepsy-associated daytime sleepiness and cataplexy, has been extensively. Despite its therapeutic benefits, sodium oxybate is not without its risks, and adverse psychiatric effects have been ...
C. Cárdenes Moreno +5 more
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Evidence of Accidental Dosing Errors with Immediate-Release Sodium Oxybate: Data from the US Food and Drug Administration Adverse Event Reporting System [PDF]
Drugs - Real World Outcomes, 2023 Introduction Sodium oxybate has been approved by the US Food and Drug Administration (FDA) to treat narcolepsy for 20 years; however, the only available products have been immediate-release (IR) formulations given twice nightly—once at bedtime and a ...
Jennifer Gudeman, Danielle Burroughs
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Evaluation of pitolisant, sodium oxybate, solriamfetol, and modafinil for the management of narcolepsy: a retrospective analysis of the FAERS database [PDF]
Frontiers in PharmacologyObjectiveNarcolepsy, a rare neurological disorder believed to have an autoimmune etiology, necessitates lifelong management. This study aimed to provide evidence supporting the safety of pharmacological treatment for narcolepsy.MethodsFive-year data on ...
Xiaodan Zhou +5 more
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Comparative efficacy of sodium oxybate versus placebo on improvement of nighttime sleep in adult patients with narcolepsy: A systematic review and meta-analysis [PDF]
Sleep Medicine: XBackground: Narcolepsy, a central hypersomnolence disorder, disrupts sleep regulation. Sodium oxybate, a CNS (central nervous system) depressant, is widely used as a treatment, but there are surprisingly very few rigorous studies comparing its ...
Adina Arshad +6 more
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Understanding the Patient Experience with Twice-Nightly Sodium Oxybate Therapy for Narcolepsy: A Social Listening Experiment [PDF]
Brain SciencesBackground/Objectives: Narcolepsy is a chronic neurologic disorder associated with substantial challenges that affect the social, emotional, and financial quality-of-life domains. A social listening analysis and structured survey were conducted to better
Maria Picone +11 more
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