Saccharin Aggravates Eosinophilic Esophagitis via MAPK3 Interaction: A Network Toxicology and Machine Learning Study With SPR Analysis. [PDF]
Food Sci NutrThis study provides a novel molecular perspective on the role of dietary factors in EoE pathogenesis. We establish saccharin as a key aggravating factor for EoE and highlight MAPK3 as a compelling therapeutic target. Our findings suggest that controlling saccharin intake represents a direct and beneficial dietary management strategy for EoE.
Yang Y +7 more
europepmc +2 more sources
Effects of Adding Ferula badrakema Root Powder with and Without Sodium Saccharin Sweetener to the Diet on Growth Performance, Immune System and Blood Metabolites of Broiler Chickens [PDF]
پژوهشهای علوم دامی ایران, 2023 Introduction: The Ferula badrakema from the Apiaceae family is a resinous plant with a strong smell that is native to Iran (Rechinger et al., 1994). The anti-bacterial and anti-fungal properties of Ferula badrakema are believed to be due to its high ...
Hamidreza Khajavi +2 more
doaj +1 more source
Menthol-like cooling compounds, including (R)-(-)-carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K. [PDF]
FEBS Open BioWe report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Saito M, Misaka T.
europepmc +2 more sources
The synthesis and characterization of polypeptide-adriamycin conjugates and its complexes with adriamycin. Part I [PDF]
, 1985 Poly(α-l-glutamic acid) (PGA) was grafted with amino acid and oligopeptide spacers up to 5 amino acids with the use of N,N'-carbonyldiimidazole and 2,3-dihydro-1,2-benz-isothiazole-3-on-1, 1-dioxide (saccharin) as an additive, and these polypeptides were
Eenink, M.J.D. +5 more
core +2 more sources
Reducing sulfur to improve thermal embrittlement in electrodeposited nickel using citric acid
Results in Surfaces and Interfaces, 2020 Electrodeposited nickel usage has been limited owing to thermal embrittlement at high temperatures. Electrodeposited nickel generally contains sulfur, and the grain boundary segregation of sulfur leads to thermal embrittlement.
Atsuya Watanabe, Yorinobu Takigawa
doaj +1 more source
In vitro assessment of antimicrobial, antioxidant, and cytotoxic properties of Saccharin-Tetrazolyl and-Thiadiazolyl derivatives: the simple dependence of the pH value on antimicrobial activity [PDF]
, 2019 The antimicrobial, antioxidant, and cytotoxic activities of a series of saccharin-tetrazolyl and -thiadiazolyl analogs were examined. The assessment of the antimicrobial properties of the referred-to molecules was completed through an evaluation of ...
Andrade, Joana M. +9 more
core +1 more source
Brain Sciences, 2023 Cancer patients regularly suffer from the behavioral symptoms of chemotherapy-induced nausea and vomiting. Particularly, it is involved in Pavlovian conditioning. Lithium chloride (LiCl) was used as the unconditioned stimulus (US) and contingent with the
Zhi-Yue Gao +3 more
doaj +1 more source
Unexpected nucleophilic participation and rearrangement of DBU in reactions with saccharin derivatives [PDF]
, 2003 DBU attacks saccharin derivatives with subsequent rearrangement to give rise to 3-[3'-(1"-azepin-2"-onyl)propylamino]-1,2-benzisothiazole-1,1-dioxide 2 after work ...
Barkley, James V. +3 more
core +1 more source
Inorganics, 2021 The reaction in the system CuII/sacNa(H)/NCNR2 (sacNa(H) = sodium saccharinate (saccharin); R = Me, Et) results in the formation of the complexes [Cu(sac)2(NCNR2)(H2O)2] (R = Me 1, Et 2) instead of the expected products derived from the saccharin ...
Yulia N. Toikka +3 more
doaj +1 more source
Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies [PDF]
, 2015 By reducing energy density, low-energy sweeteners (LES) might be expected to reduce energy intake (EI) and body weight (BW). To assess the totality of the evidence testing the null hypothesis that LES exposure (versus sugars or unsweetened alternatives ...
de Graaf, C +10 more
core +5 more sources