Results 21 to 30 of about 11,107 (217)

Drinking Water with Saccharin Sodium Alters the Microbiota-Gut-Hypothalamus Axis in Guinea Pig

Animals, 2021
The effects of saccharin, as a type of sweetener additive, on the metabolism and development of mammals are still controversial. Our previous research revealed that saccharin sodium (SS) promoted the feed intake and growth of guinea pigs.
Junrong Li, Shanli Zhu, Zengpeng Lv, Hongjian Dai, Zhe Wang, Quanwei Wei, Enayatullah Hamdard, Sheeraz Mustafa, Fangxiong Shi, Yan Fu   +9 more
doaj   +1 more source

Synthesis of N-Substituted Pyrrole-2,5-Dicarboxylic Acids from d-Galactaric Acid. [PDF]

ChemSusChem
Straightforward synthesis route to N‐substituted pyrrole‐2,5‐dicarboxylic acids. Starting from biobased d‐galactaric acid. Up to 45% yield. R = alkyl, benzyl, aryl. Pyrrole‐2,5‐dicarboxylic acid (PDCA) and its N‐substituted derivatives are interesting building blocks for macromolecular applications. However, only a few published procedures describe the
Friedrichs JJ, Stirnweiß K, Urmann C, Sieber V.   +3 more
europepmc   +2 more sources

Corticosterone Regulates Both Naturally Occurring and Cocaine‐Induced Dopamine Signaling by Selectively Decreasing Dopamine Uptake [PDF]

, 2017
Stressful and aversive events promote maladaptive reward‐seeking behaviors such as drug addiction by acting, in part, on the mesolimbic dopamine system. Using animal models, data from our laboratory and others show that stress and cocaine can interact to
Baker, David A., Bohn, Austin T., Ebben, Amanda L., Gasser, Paul J., Jasek, Isabella A., Kurtoglu, Beliz, Lovell, Marissa E., Mantsch, John R., Wheeler, Daniel S., Wheeler, Robert A.   +9 more
core   +2 more sources

Some taste substances are direct activators of G-proteins [PDF]

, 1994
Amphiphilic substances may stimulate cellular events through direct activation of G-proteins. The present experiments indicate that several amphiphilic sweeteners and the bitter tastant, quinine, activate transducin and Gi/Go-proteins.
Grünbaum, L., Naim, M., Nürnberg, B., Schultz, Günter, Seifert, Roland   +4 more
core   +3 more sources

APLICAÇÃO DA ESPECTROSCOPIA NO INFRAVERMELHO E DIFRAÇÃO DE RAIO-X NA DETERMINAÇÃO DE SACARINA EM ADOÇANTES LÍQUIDOS ARTIFICIAIS PELO MÉTODO VOLUMÉTRICO COM AG+

Eclética Química, 2018
The use of sweeteners liquid from saccharin sodium is a public health issue by the relationship with obesity and a source of sodium. The  levels of saccharin were studied in four different manufacturers in samples from trade in Vitória / ES, between ...
Jhonatas de Souza Lima, Mauro Cesar Dias, Túlio Matencio   +2 more
doaj   +1 more source

Nicotine Reprograms Aging-Related Metabolism and Protects Against Motor Decline in Mice. [PDF]

Adv Sci (Weinh)
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Jia S, Jing X, Wang R, Su M, Wang P, Feng Y, Ren X, Tu L, Wei P, Lu Z, Jia Y, Hong F, Mo Z, Zou J, Huang K, Yan C, Zou Q, Wang L, Zhong G, Zeng Z, Yu Q, Su W, Yang X, Pan F, Wang J, Wang L, Kang L, Kenny PJ, Chen Z, Liu XA.   +29 more
europepmc   +2 more sources

Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight [PDF]

, 2019
FKBP5 (FKBP51) is a glucocorticoid receptor (GR) binding protein, which acts as a co-chaperone of heat shock protein 90 (HSP90) and negatively regulates GR.
Deng, Ran, Dou, Longyu, Liang, Tiebing, Liu, Ming, Qiu, Bin, Ren, Wei, Shou, Weinian, Stewart, Robert B., Wang, Chao, Wang, Jun, Williams, Kent E., Xie, Zhongwen, Xu, Yuxue, Yong, Weidong, Zhao, Zhenwen   +14 more
core   +1 more source

Effect of food additives on key bacterial taxa and the mucosa-associated microbiota in Crohn’s disease. The ENIGMA study

Gut Microbes, 2023
Food additives have been linked to the pro-inflammatory microbial dysbiosis associated with Crohn’s disease (CD) but the underlying ecological dynamics are unknown.
J.J. Jimenez Loayza, S. Kang, L. Schooth, J. J. Teh, A. de Klerk, E. K. Noon, J. Zhang, J. Hu, A. L. Hamilton, A. Wilson-O’Brien, G. L. Trakman, W. Lin, J. Ching, L. Or, J.J.Y. Sung, J. Yu, S.C. Ng, M.A. Kamm, M. Morrison   +18 more
doaj   +1 more source

Effect of sodium saccharin on the neonatal rat bladder. [PDF]

Scanning microscopy, 1995
In a two-generation bioassay, high doses of dietary sodium saccharin (NaSac) produce bladder carcinoma in rats, whereas acid saccharin (HSac) does not effect the urothelium. NaSac and HSac administered as 5% of the diet to F0 Sprague-Dawley (SD) and F344 rats, continued through to the weaned male rats for ten additional weeks.
Cohen, Samuel M., Cano, Martin, St. John, Margaret K., Garland, Emily M., Khachab, Mohamad, Ellwein, Leon B.   +5 more
openaire   +2 more sources

Effects of non‐caloric artificial sweeteners on naïve and dextran sodium sulfate‐exposed Drosophila melanogaster

Food Frontiers, 2022
Saccharin and sucralose are worldwide used tabletop non‐caloric artificial sweeteners (NAS), and although they are considered metabolically inert and safe for consumption, recent studies observed an NAS‐mediated modulation of the intestinal microbiota ...
Inga Hubrecht, Nieves Baenas, Christian Sina, Anika E. Wagner   +3 more
doaj   +1 more source