Results 91 to 100 of about 132,649 (294)

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Solid-Phase Synthesis of Peptide−Viologen Conjugates

The Journal of Organic Chemistry, 2010
This paper presents a robust method for the conjugation of viologens to peptides using an amide coupling strategy that is compatible with standard Fmoc solid-phase peptide synthesis. Methodology is presented for monitoring the milligram scale process quantitatively by UV spectroscopy.
Joseph J, Reczek, Elisa, Rebolini, Adam R, Urbach   +2 more
openaire   +3 more sources

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, EarlyView.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

Perfluorophenyl Derivatives as Unsymmetrical Linkers for Solid Phase Conjugation

Frontiers in Chemistry, 2018
Linkers play major roles in conjugation chemistry toward the advancement of drug discovery. Two different series of fluorinated linkers were introduced to the backbone of a model peptide using solid phase peptide synthesis. These fluorinated linkers have
Saba Alapour, Anamika Sharma, Anamika Sharma, Beatriz G. de la Torre, Deresh Ramjugernath, Neil A. Koorbanally, Fernando Albericio, Fernando Albericio   +7 more
doaj   +1 more source

Solid-Phase Synthesis of Nannocystin Ax and Its Analogues

, 2023
Solid-phase total synthesis of nannocystin Ax (1) was disclosed. A coupling reaction between a peptide and a polyketide moiety was conducted on a solid support, and macrocyclization was achieved by Mitsunobu cyclization.
Satoshi Ichikawa, Kohei Kawanishi (16616712), Fumika Yakushiji, Satoshi Ichikawa (1310742), Fumika Yakushiji (1639009), Kazuki Yamamoto (1475920), Daiki Miyakita, Kohei Kawanishi, Akira Katsuyama (2796379), Akira Katsuyama, Daiki Miyakita (16616709), Kazuki Yamamoto   +11 more
core   +1 more source

One‐Step Microfluidic Manufactured Fucose‐Decorated Sweetosomes Choose the Time and the Road for Their Intracellular Journey to Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni, Mariele Montanari, Shiva Khorshid, Michele Verboni, Andrea Duranti, Simone Lucarini, Daniele Lopez, Annalisa Aluigi, Gianluca Morganti, Michele Menotta, Giovanna Panza, Daniel J. Klionsky, Barbara Canonico, Luca Casettari   +13 more
wiley   +1 more source

Chemical synthesis of proteins: a tool for protein labeling

, 2010
An ingenious stratagem useful to understand and modulate the structural and functional features of the proteins refers to the modification of their chemical structure.
De Rosa, Lucia
core  

Pushing the Limits of Solid-Phase Peptide Synthesis with Continuous Flow

Since its invention by Bruce Merrifield, solid-phase peptide synthesis has conventionally been performed in batch reactors. With systems created by Atherton, Dryland, and Sheppard in the 1980s, flow-chemistry techniques began to be applied to enhance ...
Steinauer, Angela, Mijalis, A. J., Schepartz, A., Pentelute, B. L.   +3 more
core   +1 more source

Preparation and Application of an Inexpensive α-Formylglycine Building Block Compatible with Fmoc Solid-Phase Peptide Synthesis

, 2022
α-Formylglycine (fGly) is a rare residue located in the active site of sulfatases, and serves as a precursor to pharmaceu-tically-relevant motifs. The installation of fGly motifs into peptides is currently challenging due to degradation under the acidic ...
Martin, Fascione, Nicholas, Yates, Nathalie, Signoret, Reuben, Breetveld, Matthew, Warnes, Christopher, Spicer   +5 more
core   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source