Results 101 to 110 of about 124,083 (150)

Solid‐Phase Synthesis of DOTA–Peptides

Chemistry – A European Journal, 2004
AbstractA general synthetic route to two DOTA‐linked N‐Fmoc amino acids (DOTA‐F and DOTA‐K) is described that allows insertion of DOTA at any endo‐position within a peptide sequence. Three model pentapeptides were prepared to test the general utility of these derivatives in solid‐phase peptide synthesis.
Luis M, De León-Rodriguez, Zoltan, Kovacs, Gregg R, Dieckmann, A Dean, Sherry   +3 more
openaire   +2 more sources

Solid Phase Peptide Synthesis

Journal of Macromolecular Science: Part A - Chemistry, 1976
Abstract The last two decades have been an era of rapid progress in peptide research. This era was begun by the work of Sanger on the amino acid sequence determination of insulin and by du Vigneaud on the structure determination and synthesis of oxytocin.
BRUCE W. ERICKSON, R.B. MERRIFIELD
openaire   +2 more sources

Analytical Methods for Solid Phase Peptide Synthesis

Current Organic Chemistry, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
SABATINO, GIUSEPPINA, M. Chelli, BRANDI, ALBERTO, PAPINI, ANNA MARIA   +3 more
openaire   +4 more sources

Fmoc Solid-Phase Peptide Synthesis

2015
Synthetic peptides are important as drugs and in research. Currently, the method of choice for producing these compounds is solid-phase peptide synthesis. In this nonspecialist review, we describe the scope and limitations of Fmoc solid-phase peptide synthesis. Furthermore, we provide a detailed protocol for Fmoc peptide synthesis.
Hansen, Paul Robert, Oddo, Alberto
openaire   +4 more sources

Automated Solid-Phase Peptide Synthesis

2019
The development of solid-phase peptide synthesis by Bruce Merrifield paved the way for a synthesis carried out by machines. Automated peptide synthesis is a fast and convenient way of synthesizing many peptides simultaneously. This chapter tries to give a general guidance for the development of synthesis protocols for the peptide synthesizer.
openaire   +2 more sources

SOLID-PHASE PEPTIDE SYNTHESIS

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
HOLM ARNE, LARSEN BJARNE DUE
openaire   +3 more sources

Solid-Phase Peptide Synthesis: An Introduction

2013
This chapter provides an introduction to and overview of peptide chemistry with a focus on solid-phase peptide synthesis. The background, the most common reagents, and some mechanisms are presented. This chapter also points to the different chapters and puts them into perspective.
openaire   +3 more sources

Solid Phase Peptide Synthesis

1988
By the conventional methods of organic synthesis, preparation of peptides containing more than just a few amino acids is an arduous task. Introduction of blocking groups, coupling reactions and deprotection steps entail a large number of operations, such as washing the reaction mixtures neutral after coupling, precipitation or crystallization of ...
openaire   +3 more sources

Microwave heating in solid-phase peptide synthesis

Chem. Soc. Rev., 2012
The highly refined organic chemistry in solid-phase synthesis has made it the method of choice not only to assemble peptides but also small proteins - mainly on a laboratory scale but increasingly also on an industrial scale. While conductive heating occasionally has been applied to peptide synthesis, precise microwave irradiation to heat the reaction ...
Pedersen, Søren Ljungberg, Shelton, Anne Pernille Tofteng, Malik, Leila, Jensen, Knud Jørgen   +3 more
openaire   +3 more sources

Solid-Phase Peptide Synthesis

Endeavour, 1965
EBERHARD SCHRÖDER, KLAUS LÜBKE
openaire   +4 more sources