Results 11 to 20 of about 120,164 (279)

Amino-Li-Resin-A Fiber Polyacrylamide Resin for Solid-Phase Peptide Synthesis. [PDF]

Polymers (Basel), 2022
Akintayo DC, de la Torre BG, Li Y, Albericio F.   +3 more
europepmc   +3 more sources

Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis [PDF]

Nature Communications, 2019
Palladium-catalyzed late-stage diversification of structurally complex peptides has major shortcomings. Here, the authors developed a ruthenium-catalyzed C–H alkylations of peptides allowing for fluorescence labeling, late-stage diversifications and ...
Alexandra Schischko, Nikolaos Kaplaneris, Torben Rogge, Giedre Sirvinskaite, Jongwoo Son, Lutz Ackermann   +5 more
doaj   +2 more sources

New green base for Fmoc removal in solid-phase peptide synthesis: 1,5-diazabicyclo[4.3.0]non-5-ene (DBN), a promising sustainable alternative to piperidine

Green Chemistry Letters and Reviews
Developing greener synthetic methodologies requires replacing hazardous reagents with more sustainable alternatives. In solid-phase peptide synthesis (SPPS), piperidine is the standard base for Fmoc group removal, but its toxicity, environmental concerns,
Maria Carmina Scala, Giovanni Vivenzio, Michele Manfra, Marina Sala, Pietro Campiglia   +4 more
doaj   +2 more sources

Synthetic Evaluation of Standard and Microwave-Assisted Solid Phase Peptide Synthesis of a Long Chimeric Peptide Derived from Four Plasmodium falciparum Proteins [PDF]

Molecules, 2018
An 82-residue-long chimeric peptide was synthesised by solid phase peptide synthesis (SPPS), following the Fmoc protocol. Microwave (MW) radiation-assisted synthesis was compared to standard synthesis using low loading (0.20 mmol/g) of polyethylene ...
Yahson F. Varela, Magnolia Vanegas Murcia, Manuel Elkin Patarroyo   +2 more
doaj   +2 more sources

Automated solid-phase peptide synthesis to obtain therapeutic peptides [PDF]

Beilstein Journal of Organic Chemistry, 2014
The great versatility and the inherent high affinities of peptides for their respective targets have led to tremendous progress for therapeutic applications in the last years.
Veronika Mäde, Sylvia Els-Heindl, Annette G. Beck-Sickinger   +2 more
doaj   +2 more sources

Advances in Fmoc solid-phase peptide synthesis. [PDF]

J Pept Sci, 2016
Today, Fmoc SPPS is the method of choice for peptide synthesis. Very‐high‐quality Fmoc building blocks are available at low cost because of the economies of scale arising from current multiton production of therapeutic peptides by Fmoc SPPS. Many modified derivatives are commercially available as Fmoc building blocks, making synthetic access to a broad
Behrendt R, White P, Offer J.
europepmc   +4 more sources

Magnetic nanoparticle-based solid phase peptide synthesis and the synchronous detection of their biological activity

Materials Today Advances, 2021
The solid-phase peptide synthesis (SPPS) strategy, as the main procedure of peptide manufacturing, has a profound impact on the research of peptides.
D. Luo, P. Wang, Q. Zheng, R. Han, C. Shi, L. Wang, Y. Hong, Y. Liu, Y. Sha   +8 more
doaj   +1 more source

Rhodiasolv PolarClean – a greener alternative in solid-phase peptide synthesis

Green Chemistry Letters and Reviews, 2021
PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturing, shows an excellent capacity to dissolve all Fmoc-amino acids and key coupling reagents and additives.
Ashish Kumar, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio   +3 more
doaj   +1 more source

Synthesis of the transmembrane domain of the accessory protein ORF7a of SARS‐CoV‐2 using solid phase peptide synthesis and analyzing the oligomerization state

FASEB J, 2022
Hobart T, Reichart T.
europepmc   +3 more sources

First total synthesis of hoshinoamide A

Beilstein Journal of Organic Chemistry, 2021
Hoshinoamides A, B and C, linear lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata, with potent antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum.
Haipin Zhou, Zihan Rui, Yiming Yang, Shengtao Xu, Yutian Shao, Long Liu   +5 more
doaj   +1 more source