Results 11 to 20 of about 315,815 (273)

Automated solid-phase peptide synthesis to obtain therapeutic peptides [PDF]

Beilstein Journal of Organic Chemistry, 2014
The great versatility and the inherent high affinities of peptides for their respective targets have led to tremendous progress for therapeutic applications in the last years.
Veronika Mäde, Sylvia Els-Heindl, Annette G. Beck-Sickinger   +2 more
doaj   +3 more sources

Rhodiasolv PolarClean – a greener alternative in solid-phase peptide synthesis

Green Chemistry Letters and Reviews, 2021
PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturing, shows an excellent capacity to dissolve all Fmoc-amino acids and key coupling reagents and additives.
Ashish Kumar, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio   +3 more
doaj   +2 more sources

Real-time monitoring of solid-phase peptide synthesis using a variable bed flow reactor [PDF]

Chemical Communications, 2019
On-resin aggregation and incomplete amide bond formation are major challenges for solid-phase peptide synthesis that are difficult to be monitored in real-time.
Guthrie, Duncan, Nuño, Manuel, Seeberger, Peter H., Sletten, Eric T.   +3 more
core   +3 more sources

Evaluation of greener solvents for solid-phase peptide synthesis

Green Chemistry Letters and Reviews, 2021
Polar aprotic solvents such as N,N-Dimethylformamide (DMF), N-methyl-2-pyrrolidone (NMP), N,N’-dimethylacetamide (DMAc) and chlorinated solvent such dichloromethane (DCM) are the most widely used solvents for Fmoc solid-phase peptide synthesis (SPPS ...
Katarzyna Wegner, Danielle Barnes, Kim Manzor, Agnieszka Jardine, Declan Moran   +4 more
doaj   +2 more sources

Tea Bags for Fmoc Solid-Phase Peptide Synthesis: An Example of Circular Economy. [PDF]

Molecules, 2021
Peptide synthesis is an area with a wide field of application, from biomedicine to nanotechnology, that offers the option of simultaneously synthesizing a large number of sequences for the purpose of preliminary screening, which is a powerful tool ...
Guzmán F, Gauna A, Roman T, Luna O, Álvarez C, Pareja-Barrueto C, Mercado L, Albericio F, Cárdenas C.   +8 more
europepmc   +2 more sources

Advances in Fmoc solid-phase peptide synthesis. [PDF]

J Pept Sci, 2016
Today, Fmoc SPPS is the method of choice for peptide synthesis. Very‐high‐quality Fmoc building blocks are available at low cost because of the economies of scale arising from current multiton production of therapeutic peptides by Fmoc SPPS.
Behrendt R, White P, Offer J.
europepmc   +2 more sources

Magnetic nanoparticle-based solid phase peptide synthesis and the synchronous detection of their biological activity

Materials Today Advances, 2021
The solid-phase peptide synthesis (SPPS) strategy, as the main procedure of peptide manufacturing, has a profound impact on the research of peptides.
D. Luo, P. Wang, Q. Zheng, R. Han, C. Shi, L. Wang, Y. Hong, Y. Liu, Y. Sha   +8 more
doaj   +1 more source

First total synthesis of hoshinoamide A

Beilstein Journal of Organic Chemistry, 2021
Hoshinoamides A, B and C, linear lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata, with potent antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum.
Haipin Zhou, Zihan Rui, Yiming Yang, Shengtao Xu, Yutian Shao, Long Liu   +5 more
doaj   +1 more source

Harnessing polarity and viscosity to identify green binary solvent mixtures as viable alternatives to DMF in solid-phase peptide synthesis

, 2021
Solid-phase peptide synthesis (SPPS) enables routine synthesis of virtually any type of peptide sequence and is the preferred method for peptide synthesis in academia and the pharmaceutical industry alike.
Vincent Martin, S. Jadhav, P. H. G. Egelund, Raphael Liffert, Henrik Johansson Castro, Tobias Krüger, K. Haselmann, Sebastian Thordal Le Quement, F. Albericio, Frank Dettner, Carolin Lechner, Ralph Schönleber, D. Pedersen   +12 more
semanticscholar   +1 more source

Fragment synthesis of disulfide-containing peptides

MethodsX, 2020
A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described.
Yuxuan Dai, Na Yue, Wenlong Huang, Hai Qian   +3 more
doaj   +1 more source